[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633064":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":24,"locations":30,"responsibleParty":49,"collaborators":18,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":53,"sex":59,"minAge":60,"maxAge":18,"enrollmentInfo":61,"targetDuration":18,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":18,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"State University of Londrina","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise group","EXPERIMENTAL","The exercise group will be instructed to complete 48 supervised, multicomponent physical training sessions over a 24-week period, with a frequency of two sessions per week on non-consecutive days.",[13],"Other: Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","Participants in the waitlist control group received standard medical care, without any exercise program or specific exercise recommendations. To maintain contact with the investigators and minimize study dropout, the waitlist control group received general health information through monthly online meetings.",null,[20],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":18},"Exercise","The multicomponent exercise intervention included a 10-minute warm-up consisting of balance, coordination, and stretching exercises. The main component was resistance training targeting the major muscle groups of the upper and lower body to improve strength and muscle mass. Six to eight exercises were performed using body weight, resistance bands, and dumbbells. Training progression was achieved by increasing load, repetitions, and\u002For sets, guided by the Borg 0-10 rating of perceived exertion scale, when health status allowed. The aerobic component consisted of walking, progressing to beginner-level running using short running intervals (50-100 m) interspersed with walking until longer continuous distances were achieved. Heart rate was monitored throughout the aerobic session.",[9],[25],{"name":26,"role":27,"phone":28,"phoneExt":18,"email":29},"Rafael Deminice, PhD","CONTACT","+5543991916013","rdeminice@uel.br",[31],{"facility":32,"status":18,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Universidade Estadual de Londrina, Londrina","Londrina","Paraná","86047-597","Brazil","BR",{"type":39,"coordinates":40},"Point",[41,42],-51.16278,-23.31028,{"lat":42,"lon":41},[45],{"name":46,"role":27,"phone":47,"phoneExt":18,"email":48},"Ivone Beraldo","+554333715953","cefepos@uel.br",{"type":50,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR","100633064","exercise-training-in-women-with-metastatic-breast-cancer-100633064",false,"NCT07521826","Exercise Training in Women With Metastatic Breast Cancer","Randomized Controlled Trial of a Combined Exercise Training Program on Physical Function and Quality of Life in Women With Metastatic Breast Cancer","FITCAN","Inclusion Criteria:\n\n* Women aged ≥ 18 years;\n* Confirmed diagnosis of stage IV (metastatic) breast cancer;\n* Currently undergoing medical treatment;\n* Willingness and functional independence to participate in the exercise program;\n* Medical clearance to engage in structured physical exercise.\n\nExclusion Criteria:\n\n* Presence of unstable bone metastases.\n* Untreated or symptomatic brain metastases;\n* Evidence of severe cardiovascular disease identified by electrocardiogram (ECG);\n* Severe active infection;\n* Uncontrolled severe respiratory insufficiency or dependence on supplemental oxygen at rest or during exercise;\n* Uncontrolled severe pain;\n* Any other medical condition contraindicating participation in physical exercise;\n* Conditions that impair adherence to study procedures or the ability to provide informed consent;\n* Pregnancy.","FEMALE","18 Years",{"count":62,"type":63},78,"ESTIMATED","INTERVENTIONAL",[66],"NA","The primary objective of the study is to evaluate the effects of exercise on physical function, physical fitness, and body composition, with the main components including muscular strength, cardiorespiratory fitness, muscle mass, fat mass, and fat-free mass. The secondary objectives are to examine exercise adherence and the effects of exercise on health-related quality of life (HRQoL), cancer-related fatigue, and sleep quality. Additionally, the feasibility and safety of the exercise program will be assessed.",[69,70],"Cancer","Metastases",[72,73,74,75,76],"Low muscle strength","muscle loss","loss of physical function","cardiorespiratory fitness","multimodal exercise","NOT_YET_RECRUITING","2026-04-07",{"date":80,"type":81},"2026-04-13","ACTUAL",{"date":83,"type":63},"2026-04",{"date":85,"type":63},"2028-12",{"name":5,"class":6},1]