[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100632070":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":38,"responsibleParty":57,"collaborators":24,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":24,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":78,"overallStatus":41,"whyStopped":24,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Riphah International University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Upper Limb Exercise Training","EXPERIMENTAL","Participants will undergo upper limb resistance training using an arm cycle ergometer consisting of:\n\nWarm-up: 5-10 minutes at 30-40% peak work rate Training: 2-3 sessions\u002Fweek Intensity: 50-85% peak resistance Sets: 1-3 sets of 6-15 revolutions with 1-2 minute rest Cool-down: 5-10 minutes low resistance",[13],"Other: Arm Cycle Ergometry",{"label":15,"type":10,"description":16,"interventionNames":17},"Lower Limb Exercise Training","Participants will undergo lower limb resistance training using a leg cycle ergometer consisting of:\n\nWarm-up: 5-10 minutes at 30-40% peak work rate Training: 2-3 sessions\u002Fweek Intensity: 50-85% peak resistance Sets: 1-3 sets of 6-15 revolutions with 1-2 minute rest Cool-down: 5-10 minutes low resistance",[18],"Other: Leg Cycle Ergometry",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Arm Cycle Ergometry","Participants will undergo upper limb resistance training using an arm cycle ergometer",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Leg Cycle Ergometry","Participants will undergo lower limb resistance training using a leg cycle ergometer",[15],[30],{"name":31,"affiliation":5,"role":32},"Danish Hassan, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":31,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","+92 345 7946009","danish.hassan009@gmail.com",[39],{"facility":40,"status":41,"city":42,"state":24,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Gulab Devi Chest Hospital","RECRUITING","Lahore","547000","Pakistan","PK",{"type":47,"coordinates":48},"Point",[49,50],74.35071,31.558,{"lat":50,"lon":49},[53,55],{"name":54,"role":35,"phone":24,"phoneExt":24,"email":37},"Danish Hassan",{"name":56,"role":32,"phone":24,"phoneExt":24,"email":24},"Mahnoor Shakir, MS",{"type":58,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100632070","exercises-effect-on-muscle-strength-aerobic-capacity-and-respiratory-functions-in-cystic-fibrosis-100632070",false,"NCT07508904","Exercises' Effect on Muscle Strength, Aerobic Capacity and Respiratory Functions in Cystic Fibrosis","Effects of Upper and Lower Limb Exercises on Muscle Strength, Aerobic Capacity and Respiratory Functions in Children With Cystic Fibrosis","Inclusion Criteria:\n\n* Children aged 6-18 years\n* Diagnosed with cystic fibrosis\n* Clinically stable\n* Able to perform exercise\n* Parental\u002Fguardian consent provided\n\nExclusion Criteria:\n\n* Other severe pulmonary diseases\n* Cardiovascular or orthopedic limitations\n* Surgery or hospitalization within last 1 month\n* Inability to follow instructions\n* Oxygen-dependent or ventilator-dependent patients","ALL","6 Years","18 Years",{"count":70,"type":71},22,"ESTIMATED","INTERVENTIONAL",[74],"NA","This research aims to evaluate the effects of upper and lower limb exercises on muscle strength and pulmonary function in children diagnosed with CF. While aerobic training is a known component of CF management, resistance training focused on specific limb groups has gained attention for its additional benefits. Upper limb exercises may aid respiratory muscle endurance and thoracic mobility, enhancing pulmonary mechanics. In contrast, lower limb exercises (such as cycling or squats) are associated with improved oxygen consumption (VO₂ peak), enhanced mobility, and greater lower body strength.\n\nThis randomized clinical trial will be conducted using a non-probability convenience sampling technique. The study will take place at the pediatric cystic fibrosis centers of Gulab Devi Chest Hospital and The Children's Hospital, Lahore. The targeted population includes children aged 6 to 18 years who have been diagnosed with cystic fibrosis and referred to the physiotherapy department. The study duration will be ten months following the approval of the synopsis. Eligible participants will be children aged between 6 and 18 years, clinically diagnosed with cystic fibrosis, currently stable with no history of hospitalization or significant lung infection in the past month. They should be physically able to participate in exercise and capable of following instructions, with informed consent obtained from their parents or guardians. Children will be excluded if they suffer from other severe lung diseases, cardiovascular or orthopedic conditions that restrict exercise, recent surgery or hospitalization within the last month, or if they are unable to understand instructions. Those dependent on oxygen therapy or ventilator support at all times will also be excluded.\n\nThe primary outcome measures will include lung function assessed by spirometry (FVC, FEV1), sputum production recorded through a sputum diary, and aerobic capacity measured by the Incremental Shuttle Walk Test (ISWT). Muscle strength will be evaluated for both upper and lower limbs, using a handheld dynamometer for the upper limbs and the Sit-to-Stand Test for the lower limb",[77],"Cystic Fibrosis (CF)",[79,80,81,82,83],"Cystic Fibrosis","Muscle Strength","Respiratory Function","Upper and Lower Limb Exercises","Pediatric Rehabilitation","2026-03-27",{"date":86,"type":87},"2026-04-02","ACTUAL",{"date":89,"type":87},"2025-12-01",{"date":91,"type":71},"2026-09-01",{"name":5,"class":6},1]