[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100530679":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":26,"centralContacts":31,"locations":40,"responsibleParty":62,"collaborators":10,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":10,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":10,"enrollmentInfo":73,"targetDuration":10,"studyType":76,"phases":10,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"The Institute of Molecular and Translational Medicine, Czech Republic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanically ventilated patients with primary or secondary lung injury",null,"Mechanically ventilated patients with primary or secondary lung injury due to various pathologies. Patients will be treated at intensive care units (ICU).",[13],"Diagnostic Test: Proteomic analysis of exhaled breath condensate",{"label":15,"type":10,"description":16,"interventionNames":17},"Mechanically ventilated patients without lung injury","Mechanically ventilated patients without lung injury, with various pathologies. Patients will be treated at intensive care units (ICU).",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"DIAGNOSTIC_TEST","Proteomic analysis of exhaled breath condensate","Mechanically ventilated intensive care patients will be sampled for exhaled breath condensate from the ventilator circuit.",[9,15],[25],"Molecular biological examination of the venous blood sample",[27],{"name":28,"affiliation":29,"role":30},"Emil Berta, MD PhD","IMTM, Palacky University in Olomouc, Faculty of Medicine and Dentistry","PRINCIPAL_INVESTIGATOR",[32,36],{"name":28,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","+420585632111","e.berta@upol.cz",{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},"Karel Axmann, MD","+420588445356","karel.axmann@fnol.cz",[41,55],{"facility":42,"status":43,"city":44,"state":10,"zip":45,"country":46,"countryCode":10,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Institute of Molecular and Translational Medicine, Palacky University","RECRUITING","Olomouc","77900","Czechia",{"type":48,"coordinates":49},"Point",[50,51],17.25175,49.59552,{"lat":51,"lon":50},[54],{"name":28,"role":33,"phone":34,"phoneExt":10,"email":35},{"facility":56,"status":43,"city":44,"state":10,"zip":45,"country":46,"countryCode":10,"cosmosGeoPoint":57,"geoPoint":59,"contacts":60},"University Hospital Olomouc",{"type":48,"coordinates":58},[50,51],{"lat":51,"lon":50},[61],{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},{"type":63,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100530679","exhaled-breath-condensate-analysis-in-mechanically-ventilated-patients-100530679",false,"NCT06189924","Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients","Proteomic Analysis of Exhaled Breath Condensate in Mechanically Ventilated Intensive Care Patients","Inclusion Criteria:\n\nIntensive care setting Mechanical ventilation Ventilator\u002Fventilator circuit technically suitable for sampling of exhaled breath condensate\n\nExclusion Criteria:\n\nMechanical ventilation challenging to the extent that the insertion of the sampling kit into the ventilator circuit would substantially increase the risk for respiratory deterioration","ALL","18 Years",{"count":74,"type":75},200,"ESTIMATED","OBSERVATIONAL","Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.\n\nProteomic analysis of the exhaled breath condensate will be performed using mass spectrometry and in the blood sample, corresponding changes in the DNA, RNA, proteins, and metabolites will be studied. Resulting profiles will be correlated with routinely monitored parameters in order to identify patterns corresponding to various pathologies in order to enable their early detection.",[79,80],"Acute Respiratory Failure","Critical Illness",[82,83,84,85,86,87,88],"exhaled breath condensate","proteomics","genomics","mechanical ventilation","acute respiratory failure","lung injury","intensive care","2026-06-23",{"date":91,"type":92},"2026-06-25","ACTUAL",{"date":94,"type":92},"2026-03-01",{"date":96,"type":75},"2029-12-31",{"name":5,"class":6},2]