[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552587":3},{"organization":4,"armGroups":7,"interventions":35,"overallOfficials":45,"centralContacts":49,"locations":55,"responsibleParty":68,"collaborators":10,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":10,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":10,"studyType":84,"phases":10,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":97,"whyStopped":10,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",[8,14,18,22,26,31],{"label":9,"type":10,"description":11,"interventionNames":12},"Group GB20",null,"Group GB20 will received acupuncture at acupoint GB20 twice a week 8 weeks for efficacy evaluation. And we could use the exosome-miRNA, transcriptome, oral microbiota, Schirmer's test, Tear breakup time, 6-GSI, OSDI, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.",[13],"Other: Acupuncture",{"label":15,"type":10,"description":16,"interventionNames":17},"Group GB20 plus BL2","Group GB20 plus BL2 will received acupuncture at acupoint GB20 plus BL2 twice a week 8 weeks for efficacy evaluation. And we could use the exosome-miRNA, transcriptome, oral microbiota, Schirmer's test, Tear breakup time, 6-GSI, OSDI, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"non AIDDES Healthy Controls (NHC)","1. ACUDES: Healthy control group will not received any treatment. And we could use the exosome-miRNA, transcriptome, oral microbiota, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability to find the difference with the comparison between the dry eye syndrome and healthy control.\n2. TBDESJS: Non DES SJS Healthy Controls (NHC) will received Chinese herbal tea TBDESJS 8 weeks on Nourishing Yin and Moistening Dryness the ocular dryness evaluation. And we could use the Schirmer's test, Tear breakup time, Ocular Surface Disease Index (OSDI), EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), Pittsburgh Sleep Quality Index (PSQI), Ford Insomnia Response to Stress Test (FIRST), cytokine markers, Whole-genome genotyping, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Waiting list","Group Waiting list will not received any treatment. at acupoint GB20 plus BL2 twice a week 8 weeks for efficacy evaluation. And we could use the exosome-miRNA, transcriptome, oral microbiota, Schirmer's test, Tear breakup time, 6-GSI, OSDI, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.",[13],{"label":27,"type":10,"description":28,"interventionNames":29},"Dry eye syndrome (DES)","Dry eye syndrome (DES) will received Chinese herbal tea TBDESJS 8 weeks on Nourishing Yin and Moistening Dryness the ocular dryness evaluation. And we could use the exosome-miRNA, transcriptome, Schirmer's test, Tear breakup time, Ocular Surface Disease Index (OSDI), EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), Pittsburgh Sleep Quality Index (PSQI), Ford Insomnia Response to Stress Test (FIRST), cytokine markers, Whole-genome genotyping, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.",[30],"Other: TBDESJS",{"label":32,"type":10,"description":33,"interventionNames":34},"Sjögren's syndrome (SJS)","Sjögren's syndrome (SJS) will received Chinese herbal tea TBDESJS 8 weeks on Nourishing Yin and Moistening Dryness the ocular dryness evaluation. And we could use the exosome-miRNA, transcriptome, Schirmer's test, Tear breakup time, Ocular Surface Disease Index (OSDI), EULAR Sjogren's Syndrome Patient Reported Index (ESSPRI), Pittsburgh Sleep Quality Index (PSQI), Ford Insomnia Response to Stress Test (FIRST), cytokine markers, Whole-genome genotyping, TCM pattern, Traditional Chinese Medicine (TCM) tongue diagnosis, TCM pulse diagnosis, and TCM heart rate variability for this purpose.",[30],[36,41],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":10},"OTHER","TBDESJS","Chinese herbal tea TBDESJS",[27,32],{"type":37,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"Acupuncture","acupuncture GB20 or GB20 plus BL2",[9,15,23,19],[46],{"name":47,"affiliation":5,"role":48},"Ching-Mao Chang, M.D., Ph.D.","PRINCIPAL_INVESTIGATOR",[50],{"name":47,"role":51,"phone":52,"phoneExt":53,"email":54},"CONTACT","88628757453","333","magicbjp@gmail.com",[56],{"facility":57,"status":10,"city":58,"state":10,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":10},"Ching-Mao Chang","Taipei","112","Taiwan","TW",{"type":63,"coordinates":64},"Point",[65,66],121.52639,25.05306,{"lat":66,"lon":65},{"type":69,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100552587","exosome-mirna-and-transcriptome-profiling-of-dry-eye-syndrome-and-sjogrens-syndrome-100552587",false,"NCT06475027","Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome","Systematic Dissection of Exosome-miRNA and Transcriptome Profiling of Dry Eye Syndrome and Sjogren's Syndrome for Alleviating the Sicca Symptoms","Dry eye syndrome\n\n* Inclusion Criteria: aged between 20 and 75 years Schirmer's test less than 10 mm\u002F5 min\n* Exclusion Criteria: Pregnancy With eye inflammation or infectious eye disease Accepted operation of eye\n\nSjögren's syndrome\n\n* Inclusion Criteria: primary or secondary SS aged between 20 and 75 years fulfilled the 2002 American-European Consensus Criteria for SS (AECG) had no abnormal findings of immune, liver, kidney, or blood function evaluations.\n* Exclusion Criteria: a history of alcohol abuse, diabetes mellitus, or major life-threatening condition pregnancy or breastfeeding steroid pulse therapy within three months prior to the commencement of our study.\n\nnon AIDDES Healthy Controls\n\n* Inclusion Criteria: aged between 20 and 75 years without any Chronic disease\n* Exclusion Criteria: any Sjögren's syndrome or Dry eye syndrome.",true,"ALL","20 Years","75 Years",{"count":82,"type":83},220,"ESTIMATED","OBSERVATIONAL","This study combines data from two trials testing acupuncture (ACUDES) and a Chinese herbal tea bag TBDESJS for Dry Eye Syndrome and Sjögren's syndrome. Both treatments improved tear production. Researchers will now analyze participants' blood remaining samples and other data to understand how these therapies work. They will use advanced methods to identify tiny RNA molecules and immune system activity. This integrated approach aims to explain how acupuncture and TBDESJS improve dryness and support their use in managing these conditions.",[87,88,89],"Dry Eye Syndrome","Sjogren's Syndrome","Xerophthalmia",[91,92,89,42,93,94,95,96],"Dry eye syndrome","Sjögren's syndrome","Exosome","transcriptome","GB20","BL2","NOT_YET_RECRUITING","2024-06-20",{"date":100,"type":101},"2024-06-26","ACTUAL",{"date":103,"type":83},"2024-07-01",{"date":105,"type":83},"2026-12-31",{"name":5,"class":6},1]