[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577366":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":15,"locations":21,"responsibleParty":374,"collaborators":7,"id":376,"slug":377,"hasResults":378,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":7,"eligibilityCriteria":382,"healthyVolunteers":378,"sex":383,"minAge":384,"maxAge":7,"enrollmentInfo":7,"targetDuration":7,"studyType":385,"phases":7,"briefSummary":386,"conditions":387,"keywords":7,"overallStatus":24,"whyStopped":7,"lastUpdateSubmitDate":390,"lastUpdatePostDateStruct":391,"startDateStruct":7,"completionDateStruct":7,"leadSponsor":394,"locationsCount":395},{"fullName":5,"class":6},"Nuvalent Inc.","INDUSTRY",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":13},"DRUG","NVL-520","Oral tablet",[14],"Zidesamtinib",[16],{"name":17,"role":18,"phone":19,"phoneExt":7,"email":20},"Contact for Program Information","CONTACT","877 768 4303","MedicineAccess@clinigengroup.com",[22,36,46,56,62,72,82,92,104,114,124,136,146,158,168,178,188,199,208,216,225,234,243,254,260,269,279,285,296,302,311,317,328,337,346,358,365],{"facility":23,"status":24,"city":25,"state":26,"zip":27,"country":28,"countryCode":29,"cosmosGeoPoint":30,"geoPoint":35,"contacts":7},"University of Colorado Anschutz School of Medicine","AVAILABLE","Aurora","Colorado","80045","United States","US",{"type":31,"coordinates":32},"Point",[33,34],-104.83192,39.72943,{"lat":34,"lon":33},{"facility":37,"status":24,"city":38,"state":39,"zip":40,"country":28,"countryCode":29,"cosmosGeoPoint":41,"geoPoint":45,"contacts":7},"University of Chicago Medical Center","Chicago","Illinois","60637",{"type":31,"coordinates":42},[43,44],-87.65005,41.85003,{"lat":44,"lon":43},{"facility":47,"status":24,"city":48,"state":49,"zip":50,"country":28,"countryCode":29,"cosmosGeoPoint":51,"geoPoint":55,"contacts":7},"Massachusetts General Hospital","Boston","Massachusetts","02114",{"type":31,"coordinates":52},[53,54],-71.05977,42.35843,{"lat":54,"lon":53},{"facility":57,"status":24,"city":48,"state":49,"zip":58,"country":28,"countryCode":29,"cosmosGeoPoint":59,"geoPoint":61,"contacts":7},"Dana-Farber Cancer Institute","02215",{"type":31,"coordinates":60},[53,54],{"lat":54,"lon":53},{"facility":63,"status":24,"city":64,"state":65,"zip":66,"country":28,"countryCode":29,"cosmosGeoPoint":67,"geoPoint":71,"contacts":7},"Memorial Sloan Kettering Cancer Center","Manhattan","New York","10065",{"type":31,"coordinates":68},[69,70],-73.96625,40.78343,{"lat":70,"lon":69},{"facility":73,"status":24,"city":74,"state":75,"zip":76,"country":28,"countryCode":29,"cosmosGeoPoint":77,"geoPoint":81,"contacts":7},"Fox Chase Cancer Center","Philadelphia","Pennsylvania","19111",{"type":31,"coordinates":78},[79,80],-75.16362,39.95238,{"lat":80,"lon":79},{"facility":83,"status":24,"city":84,"state":85,"zip":86,"country":28,"countryCode":29,"cosmosGeoPoint":87,"geoPoint":91,"contacts":7},"University of Washington \u002F Fred Hutchinson Cancer Center","Seattle","Washington","98109",{"type":31,"coordinates":88},[89,90],-122.33207,47.60621,{"lat":90,"lon":89},{"facility":93,"status":24,"city":94,"state":95,"zip":96,"country":97,"countryCode":98,"cosmosGeoPoint":99,"geoPoint":103,"contacts":7},"Chris O'Brien Lifehouse","Camperdown","New South Wales","2050","Australia","AU",{"type":31,"coordinates":100},[101,102],151.17642,-33.88965,{"lat":102,"lon":101},{"facility":105,"status":24,"city":106,"state":107,"zip":108,"country":97,"countryCode":98,"cosmosGeoPoint":109,"geoPoint":113,"contacts":7},"Peter MacCallum Cancer Centre","Melbourne","Victoria","3000",{"type":31,"coordinates":110},[111,112],144.96332,-37.814,{"lat":112,"lon":111},{"facility":115,"status":24,"city":116,"state":7,"zip":108,"country":117,"countryCode":118,"cosmosGeoPoint":119,"geoPoint":123,"contacts":7},"UZLeuven","Leuven","Belgium","BE",{"type":31,"coordinates":120},[121,122],4.70093,50.87959,{"lat":122,"lon":121},{"facility":125,"status":24,"city":126,"state":127,"zip":128,"country":129,"countryCode":130,"cosmosGeoPoint":131,"geoPoint":135,"contacts":7},"Cross Cancer Institute","Edmonton","Alberta","T6G 1Z2","Canada","CA",{"type":31,"coordinates":132},[133,134],-113.46871,53.55014,{"lat":134,"lon":133},{"facility":137,"status":24,"city":138,"state":139,"zip":140,"country":129,"countryCode":130,"cosmosGeoPoint":141,"geoPoint":145,"contacts":7},"Princess Margaret Hospital","Toronto","Ontario","M5G 2M9",{"type":31,"coordinates":142},[143,144],-79.39864,43.70643,{"lat":144,"lon":143},{"facility":147,"status":24,"city":148,"state":149,"zip":150,"country":151,"countryCode":152,"cosmosGeoPoint":153,"geoPoint":157,"contacts":7},"Centre Leon Berard","Lyon","Auvergne-Rhône-Alpes","69008","France","FR",{"type":31,"coordinates":154},[155,156],4.84789,45.74906,{"lat":156,"lon":155},{"facility":159,"status":24,"city":160,"state":161,"zip":162,"country":151,"countryCode":152,"cosmosGeoPoint":163,"geoPoint":167,"contacts":7},"GCS IUCT Oncopole","Toulouse","Occitanie","31059",{"type":31,"coordinates":164},[165,166],1.44367,43.60426,{"lat":166,"lon":165},{"facility":169,"status":24,"city":170,"state":171,"zip":172,"country":151,"countryCode":152,"cosmosGeoPoint":173,"geoPoint":177,"contacts":7},"CHU de Nantes","Nantes","Pays de la Loire Region","44800",{"type":31,"coordinates":174},[175,176],-1.55336,47.21725,{"lat":176,"lon":175},{"facility":179,"status":24,"city":180,"state":181,"zip":182,"country":151,"countryCode":152,"cosmosGeoPoint":183,"geoPoint":187,"contacts":7},"Institut Gustave Roussy","Villejuif","Île-de-France Region","94800",{"type":31,"coordinates":184},[185,186],2.35992,48.7939,{"lat":186,"lon":185},{"facility":189,"status":24,"city":190,"state":7,"zip":191,"country":192,"countryCode":193,"cosmosGeoPoint":194,"geoPoint":198,"contacts":7},"IRCCS Istituto Tumori Giovanni Paolo II","Bari","70124","Italy","IT",{"type":31,"coordinates":195},[196,197],16.86982,41.12066,{"lat":197,"lon":196},{"facility":200,"status":24,"city":201,"state":7,"zip":202,"country":192,"countryCode":193,"cosmosGeoPoint":203,"geoPoint":207,"contacts":7},"L'Istituto Europeo di Oncologia S.r.l.","Milan","20141",{"type":31,"coordinates":204},[205,206],9.18951,45.46427,{"lat":206,"lon":205},{"facility":209,"status":24,"city":201,"state":7,"zip":210,"country":192,"countryCode":193,"cosmosGeoPoint":211,"geoPoint":215,"contacts":7},"Fondazione IRCCS Istituto Nazionale dei Tumori","20133",{"type":31,"coordinates":212},[213,214],12.59836,42.78235,{"lat":214,"lon":213},{"facility":217,"status":24,"city":218,"state":7,"zip":219,"country":192,"countryCode":193,"cosmosGeoPoint":220,"geoPoint":224,"contacts":7},"IRCCS Istituto Oncologico Veneto","Padova","35128",{"type":31,"coordinates":221},[222,223],11.14261,44.38225,{"lat":223,"lon":222},{"facility":226,"status":24,"city":227,"state":7,"zip":228,"country":192,"countryCode":193,"cosmosGeoPoint":229,"geoPoint":233,"contacts":7},"AUSL della Romagna - Ravenna","Ravenna","48121",{"type":31,"coordinates":230},[231,232],12.20121,44.41344,{"lat":232,"lon":231},{"facility":235,"status":24,"city":236,"state":7,"zip":237,"country":192,"countryCode":193,"cosmosGeoPoint":238,"geoPoint":242,"contacts":7},"Istituto Nazionale Tumori \"Regina Elena","Roma","00144",{"type":31,"coordinates":239},[240,241],11.10642,44.99364,{"lat":241,"lon":240},{"facility":244,"status":24,"city":245,"state":7,"zip":246,"country":247,"countryCode":248,"cosmosGeoPoint":249,"geoPoint":253,"contacts":7},"Antoni van Leeuwenhoek Hospital","Amsterdam","1006 BE","Netherlands","NL",{"type":31,"coordinates":250},[251,252],4.88969,52.37403,{"lat":252,"lon":251},{"facility":255,"status":24,"city":245,"state":7,"zip":256,"country":247,"countryCode":248,"cosmosGeoPoint":257,"geoPoint":259,"contacts":7},"Netherlands Cancer Institute: NKI","1066 CX",{"type":31,"coordinates":258},[251,252],{"lat":252,"lon":251},{"facility":261,"status":24,"city":262,"state":7,"zip":263,"country":247,"countryCode":248,"cosmosGeoPoint":264,"geoPoint":268,"contacts":7},"University Medical Center Groningen","Groningen","9713 GZ",{"type":31,"coordinates":265},[266,267],6.56667,53.21917,{"lat":267,"lon":266},{"facility":270,"status":24,"city":271,"state":7,"zip":272,"country":271,"countryCode":273,"cosmosGeoPoint":274,"geoPoint":278,"contacts":7},"National University Hospital Singapore","Singapore","119074","SG",{"type":31,"coordinates":275},[276,277],103.85007,1.28967,{"lat":277,"lon":276},{"facility":280,"status":24,"city":271,"state":7,"zip":281,"country":271,"countryCode":273,"cosmosGeoPoint":282,"geoPoint":284,"contacts":7},"National Cancer Centre Singapore","168583",{"type":31,"coordinates":283},[276,277],{"lat":277,"lon":276},{"facility":286,"status":24,"city":287,"state":7,"zip":288,"country":289,"countryCode":290,"cosmosGeoPoint":291,"geoPoint":295,"contacts":7},"Uomi Cancer Center-Clinica Tres Torres","Barcelona","08017","Spain","ES",{"type":31,"coordinates":292},[293,294],2.15899,41.38879,{"lat":294,"lon":293},{"facility":297,"status":24,"city":287,"state":7,"zip":298,"country":289,"countryCode":290,"cosmosGeoPoint":299,"geoPoint":301,"contacts":7},"Hospital Universitario Vall d'Hebron","08035",{"type":31,"coordinates":300},[293,294],{"lat":294,"lon":293},{"facility":303,"status":24,"city":304,"state":7,"zip":305,"country":289,"countryCode":290,"cosmosGeoPoint":306,"geoPoint":310,"contacts":7},"Gregorio Marañón General University Hospital","Madrid","28007",{"type":31,"coordinates":307},[308,309],-3.70256,40.4165,{"lat":309,"lon":308},{"facility":312,"status":24,"city":304,"state":7,"zip":313,"country":289,"countryCode":290,"cosmosGeoPoint":314,"geoPoint":316,"contacts":7},"Hospital Univ Doce de Octubre","28041",{"type":31,"coordinates":315},[308,309],{"lat":309,"lon":308},{"facility":318,"status":24,"city":319,"state":7,"zip":320,"country":321,"countryCode":322,"cosmosGeoPoint":323,"geoPoint":327,"contacts":7},"Chung Shan Medical University","Taichung","402306","Taiwan","TW",{"type":31,"coordinates":324},[325,326],120.6839,24.1469,{"lat":326,"lon":325},{"facility":329,"status":24,"city":330,"state":7,"zip":331,"country":321,"countryCode":322,"cosmosGeoPoint":332,"geoPoint":336,"contacts":7},"National Cheng Kung University Hospital","Tainan","70403",{"type":31,"coordinates":333},[334,335],120.21333,22.99083,{"lat":335,"lon":334},{"facility":338,"status":24,"city":339,"state":7,"zip":340,"country":321,"countryCode":322,"cosmosGeoPoint":341,"geoPoint":345,"contacts":7},"National Taiwan University Hospital","Taipei","100229",{"type":31,"coordinates":342},[343,344],121.52639,25.05306,{"lat":344,"lon":343},{"facility":347,"status":24,"city":348,"state":349,"zip":350,"country":351,"countryCode":352,"cosmosGeoPoint":353,"geoPoint":357,"contacts":7},"The Royal Marsden Hospital","Sutton","Surrey","SM2 5PT","United Kingdom","UK",{"type":31,"coordinates":354},[355,356],-0.2,51.35,{"lat":356,"lon":355},{"facility":347,"status":24,"city":359,"state":7,"zip":350,"country":351,"countryCode":352,"cosmosGeoPoint":360,"geoPoint":364,"contacts":7},"London",{"type":31,"coordinates":361},[362,363],-0.12574,51.50853,{"lat":363,"lon":362},{"facility":366,"status":24,"city":367,"state":7,"zip":368,"country":351,"countryCode":352,"cosmosGeoPoint":369,"geoPoint":373,"contacts":7},"The Christie Hospital","Manchester","M20 4BX",{"type":31,"coordinates":370},[371,372],-2.23743,53.48095,{"lat":372,"lon":371},{"type":375,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100577366","expanded-access-program-of-zidesamtinib-nvl-520-for-patients-with-advanced-ros1-nsclc-or-other-ros1-solid-tumors-100577366",false,"NCT06797362","Expanded Access Program of Zidesamtinib (NVL-520) for Patients With Advanced ROS1+ NSCLC or Other ROS1+ Solid Tumors","Expanded Access Treatment of Zidesamtinib (NVL-520) in Patients With Advanced ROS1+ NSCLC or Other ROS1+ Solid Tumors","Inclusion Criteria:\n\n1. Age ≥18 years.\n2. Histologically or cytologically confirmed locally advanced or metastatic NSCLC or other solid tumor with documented ROS1 rearrangement.\n3. Previously received at least 1 prior ROS1 TKI, with no comparable or satisfactory alternative treatment options, in the opinion of the treating physician.\n4. Enrollment in a clinical trial of zidesamtinib is not possible.\n5. Adequate organ function and bone marrow reserve.\n\nExclusion Criteria:\n\n1. Prior receipt of zidesamtinib.\n2. Previous surgery, chemotherapy, radiotherapy or other anti-cancer therapy or participation in other studies within timeframe indicated in the protocol.\n3. Ongoing anti-cancer therapy.\n4. Eligible for ongoing clinical trial with zidesamtinib","ALL","18 Years","EXPANDED_ACCESS","The Expanded Access Program will provide an alternate mechanism for these patients, who lack satisfactory therapeutic alternatives and cannot participate in a zidesamtinib clinical trial, to access investigational zidesamtinib.",[388,389],"Non Small Cell Lung Cancer","ROS1-positive Non-Small Cell Lung Cancer (NSCLC)","2026-06-11",{"date":392,"type":393},"2026-06-15","ACTUAL",{"name":5,"class":6},37]