[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639113":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":15,"locations":10,"responsibleParty":22,"collaborators":26,"id":30,"slug":31,"hasResults":32,"nctId":33,"briefTitle":34,"officialTitle":35,"acronym":36,"eligibilityCriteria":37,"healthyVolunteers":32,"sex":38,"minAge":39,"maxAge":10,"enrollmentInfo":40,"targetDuration":10,"studyType":43,"phases":10,"briefSummary":44,"conditions":45,"keywords":48,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":10},{"fullName":5,"class":6},"IRCCS San Raffaele","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"One-stage DTI",null,"Patients who underwent one-stage direct-to-implant pre-pectoral reconstructive strategy",{"label":13,"type":10,"description":14,"interventionNames":10},"Two-stage TE-I","Patients who underwent two-stage expander-implant pre-pectoral reconstructive strategy",[16],{"name":17,"role":18,"phone":19,"phoneExt":20,"email":21},"Rosa Di Micco, MD, PhD","CONTACT","+39 022643","4565","dimicco.rosa@hsr.it",{"type":23,"investigatorFullName":24,"investigatorTitle":25,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Rosa Di Micco, MD","MD, PhD",[27],{"name":28,"class":29},"Regional Hospital Lugano (EOC), Switzerland","UNKNOWN","100639113","expander-based-versus-direct-to-implant-pre-pectoral-breast-reconstruction-a-comparative-analysis-of-surgical-outcomes-100639113",false,"NCT07593651","EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes","EXpander-based Versus Direct to Implant PRE-pectoral Breast Reconstruction: a Comparative Analysis of Surgical Outcomes : the EXPRESsO Study","EXPRESSO","Inclusion Criteria:\n\n* Female patients ≥18 years\n* Patients undergoing unilateral or bilateral therapeutic mastectomy for breast cancer\n* Patients undergoing pre-pectoral implant-based breast reconstruction, either:\n\n  * One-stage DTI, or\n  * Two-stage TE-I\n* Use of implant with or without biological or synthetic mesh\n* Contralateral prophylactic mastectomy allowed if a therapeutic mastectomy was performed on one side\n\nExclusion Criteria:\n\n* Male patients\n* Subpectoral implant-based reconstruction\n* Autologous breast reconstruction\n* Delayed reconstructions not performed at the time of mastectomy\n* Incomplete clinical or follow-up data for primary endpoint analysis","FEMALE","18 Years",{"count":41,"type":42},276,"ESTIMATED","OBSERVATIONAL","Recent advances in breast surgery, together with the increasing adoption of conservative surgical approaches, have renewed interest in pre-pectoral implant-based breast reconstruction. Within this reconstructive paradigm, surgeons may employ two distinct strategies:\n\n(i) immediate reconstruction using a direct-to-implant approach (DTI), or (ii) a two-stage reconstruction consisting of tissue expander placement followed by definitive implant insertion (TE-I).\n\nEach approach is associated with specific indications, advantages, and inherent limitations.\n\nThe EXPRESSO study aims to retrospectively compare surgical outcomes between pre-pectoral DTI and TE-I breast reconstruction. By providing real-world evidence on these reconstructive strategies, this study seeks to inform surgical decision-making and to optimize reconstructive outcomes in contemporary breast cancer care.",[46,47],"Breast Cancer","Operable Breast Cancer",[49,50,51],"breast cancer","Mastectomy","Pre-pectoral reconstruction","NOT_YET_RECRUITING","2026-05-11",{"date":55,"type":56},"2026-05-18","ACTUAL",{"date":58,"type":42},"2026-06",{"date":60,"type":42},"2027-12",{"name":5,"class":6}]