[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100547841":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":45,"collaborators":48,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":10,"eligibilityCriteria":57,"healthyVolunteers":54,"sex":58,"minAge":59,"maxAge":10,"enrollmentInfo":60,"targetDuration":10,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Case group",null,"Participants who were diagnosed as advanced malignancy and would receive 2 cycles of personal therapy based on PTC drug screening tests.",[13],"Diagnostic Test: Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","Patient-derived tumor-like cell clusters (PTC) drug sensitivity testing.","Fresh malignant effusion samples were collected from advanced malignancy patients for PTC drug sensitivity testing, then assess the accuracy of this diagnostic test by combination and analysis with final clinical outcome.",[9],[21],{"name":22,"affiliation":5,"role":23},"Liu Huang","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},"CONTACT","63639656","huangliu@tjh.tjmu.edu.cn",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Wuhan","Hubei","430030","China","CN",{"type":38,"coordinates":39},"Point",[40,41],114.26667,30.58333,{"lat":41,"lon":40},[44],{"name":22,"role":26,"phone":27,"phoneExt":10,"email":28},{"type":46,"investigatorFullName":22,"investigatorTitle":47,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology",[49],{"name":50,"class":51},"Beijing GeneX MedLab Co., Ltd","INDUSTRY","100547841","exploratory-study-of-precise-therapy-for-advanced-tumor-patients-with-malignant-hydrothorax-or-ascites-by-using-ptc-drug-sensitivity-testing-100547841",false,"NCT06413212","Exploratory Study of Precise Therapy for Advanced Tumor Patients With Malignant Hydrothorax or Ascites by Using PTC Drug Sensitivity Testing","Inclusion Criteria:\n\n1. 18 to 75 years old, regardless of gender.\n2. Score of nutrition risk screening 2002 (NRS2002) is less than 3, NRS20023.\n3. Advanced and unresectable malignancy confirmed by biopsy diagnosis.\n4. Able to tolerate anti-tumor treatment, and without serious cardiopulmonary and other underlying diseases.\n5. Score of eastern cooperative oncology group (ECOG) is not higher than 2, ECOG≤2.\n6. Anticipated survival exceed six months.\n7. At least one measurable lesions (according to RECIST 1.1)\n8. Resistance or intolerance to standard therapy regimens.\n9. Signed informed consent form voluntarily.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women.\n2. Have Participated other clinical trials in six months.\n3. Severe liver dysfunction.\n4. Severe renal dysfunction.\n5. Patients with cognitive disorder, mental diseases and terrible compliance.\n6. Allergic to known chemotherapeutic agents.\n7. Other circumstance not suitable to participate in this trial determined by investigators.","ALL","18 Years",{"count":61,"type":62},55,"ESTIMATED","OBSERVATIONAL","To explore the consistency between result of PTC drug screening tests and actual clinical outcome for patients with advanced malignancy.",[66,67,68,69],"Lung Cancer","Breast Cancer","Gastric Cancer","Colorectal Cancer",[71],"PTC: Patient-derived tumor-like cell clusters","2025-05-31",{"date":74,"type":75},"2025-06-04","ACTUAL",{"date":77,"type":75},"2023-08-04",{"date":79,"type":62},"2025-12",{"name":22,"class":6},1]