[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627898":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":27,"centralContacts":31,"locations":37,"responsibleParty":55,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":64,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":21,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":83,"overallStatus":40,"whyStopped":21,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"National University of Singapore","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Arm","EXPERIMENTAL","The participants will be administered a powder oral nutritional supplement containing a synbiotic blend of prebiotics and probiotic, a protein blend and a micronutrient blend, combined with supervised exercise for a total of 12 weeks.",[13,14],"Behavioral: Supervised exercise program","Dietary Supplement: a balanced micronutrient blend",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"BEHAVIORAL","Supervised exercise program","A supervised exercise intervention consisting of resistance and endurance training, delivered two times per week, with each session lasting 60 minutes, conducted by an exercise physiologist in the gym's clinic in Singapore.",[9],null,{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":21},"DIETARY_SUPPLEMENT","a balanced micronutrient blend","A balanced micronutrient blend containing soral nutritional supplement in powder form containing a synbiotic blend of prebiotics and probiotic, a protein blend and a micronutrient blend provided by Danone Global R\\&I Center.\n\nThe participant will be required to take two servings of the study product daily for 12 weeks.",[9],[28],{"name":29,"affiliation":5,"role":30},"Prof. Andrea Britta Maier, MD, PHD, FRACP","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Mazzarine Dotou, PhD","CONTACT","+65 87264704","mazzarine@nus.edu.sg",[38],{"facility":39,"status":40,"city":41,"state":21,"zip":42,"country":41,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"MD11 Clinical Research Centre, #03-01, 10 Medical Drive","RECRUITING","Singapore","117597","SG",{"type":45,"coordinates":46},"Point",[47,48],103.85007,1.28967,{"lat":48,"lon":47},[51,53],{"name":52,"role":34,"phone":35,"phoneExt":21,"email":36},"Mazzarine Dotou, PhD, MBA",{"name":54,"role":30,"phone":21,"phoneExt":21,"email":21},"Andrea Britta Maier, MD, PhD, FRACP",{"type":30,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Andrea Maier","Oon Chiew Seng Professor in Medicine, Healthy Ageing and Dementia Research",[59],{"name":60,"class":61},"Danone Global Research & Innovation Center","INDUSTRY","100627898","exploratory-study-on-a-multi-nutrient-supplement-and-exercise-program-for-improving-health-markers-associated-to-longevity-in-pre-frail-adults-100627898",false,"NCT07454616","Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults","A Single-arm Exploratory Study to Investigate the Feasibility to Develop a Composite Score That Encompasses Gut (Microbiome), Muscle, Immune, Cognition Outcomes Based on a 12-weeks Intervention of a Novel Multi-nutrient Supplement Containing Synbiotics, Combined With Supervised Exercise in Pre-frail Individuals Aged 50 - 80 Years Old.","RtM","Inclusion Criteria\n\n1. Singapore residents of all ethnic groups\n2. Adults aged 50-80 years (both male and female)\n3. Body mass index (BMI) ≥18 kg\u002Fm²\n4. Classified as Prefrailty according to Fried frailty criteria\n5. Willing and able to attend all data collection visits and to comply with the exercise and supplementation protocols.\n6. Able and willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Current use of supplements containing: Bifidobacterium longum 536 (BB536) like Kordel's BB536 bifidus; Bifidobacterium longum such as GniiB immunity; GOS (Galacto-oligosaccharides); FOS (Fructo-oligosaccharides); Inulin or any commercial healthy-aging powdered milk products\n2. BMI \\>30 kg\u002Fm2 3 Being on special diets including but not limited to ketogenic diets or diets prescribed by a healthcare professional\n\n4\\. Received any vaccination within the past 8 weeks. 5. Inition of new medication or use of medications affecting gastrointestinal function within the past 8 weeks, including but not limited to antibiotics or Proton pump inhibitors 6. Known allergies or intolerances, including, soy allergy; fibre allergy (e.g., GOS) or requirement for a fibre-free diet; fish allergy; Cow's milk protein allergy or lactose intolerance; galactosaemia 7. More than two unstable chronic conditions (e.g., hypertension, diabetes, hyperlipidemia, osteoarthritis, COPD) 8. Medical conditions for which probiotic use is contraindicated, including but not limited to immunocompromised individuals, astrointestinal failure or severe gastrointestinal disturbances (e.g., blood in stool), presence of a central venous catheter, open wounds following surgery 9. Contraindications to oral feeding, including gastrointestinal failure, complete intestinal obstruction, inability to access the gut or high loss intestinal fistulae 10. Known renal disease were unable to tolerate 2 servings per day. 11. Intake of supplemental calcium \\>500 mg\u002Fday or vitamin D \\>40 µg\u002Fday (1600 IU) from all sources, including diet and supplements 12. Use of medications that may interact with or impair absorption of milk products (e.g., tetracyclines) 13. Any other condition deemed by PI that may compromise participant safety and study compliance.","ALL","50 Years","80 Years",{"count":74,"type":75},40,"ESTIMATED","INTERVENTIONAL",[78],"NA","Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life. Prefrailty represents an early stage where interventions may prevent or reverse these declines. This study aims to evaluate whether a 12-week combined Synbiotic enriched oral nutritional supplement and supervised exercise program can improve muscle strength and mass, gut microbiome composition, immune function, and cognitive performance in prefrail adults aged 50-80 years.",[81,82],"Pre-Frailty","Aging",[84,85,86,87,88],"Prefrail elderly","Gut microbiome","Nutritional supplementation","supervised exercise","Biological age markers","2026-03-03",{"date":91,"type":92},"2026-03-06","ACTUAL",{"date":94,"type":92},"2025-09-22",{"date":96,"type":75},"2026-05-08",{"name":5,"class":6},1]