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Giuliano Isontina - S.C. Ematologia","Trieste",{"type":34,"coordinates":281},[282,283],13.77678,45.64953,{"lat":283,"lon":282},[286,290],{"name":287,"role":20,"phone":288,"phoneExt":10,"email":289},"Elisa Lucchini, MD","+390403992677","elisa.lucchini@asugi.sanita.fvg.it",{"name":287,"role":16,"phone":10,"phoneExt":10,"email":10},{"facility":292,"status":103,"city":293,"state":10,"zip":10,"country":31,"countryCode":32,"cosmosGeoPoint":294,"geoPoint":298,"contacts":299},"A.O.U.I. di Verona - Ematologia","Verona",{"type":34,"coordinates":295},[296,297],10.9938,45.43854,{"lat":297,"lon":296},[300,304],{"name":301,"role":20,"phone":302,"phoneExt":10,"email":303},"Francesca Maria Quaglia, MD","+390458124827","francescamaria.quaglia@aovr.veneto.it",{"name":301,"role":16,"phone":10,"phoneExt":10,"email":10},{"type":306,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100561287","exploring-the-clinical-impact-of-myc-aberrations-and-their-relationship-with-microenvironment-in-diffuse-large-b-cell-lymphoma-and-high-grade-b-cell-lymphoma-100561287",false,"NCT06588205","Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma","Multicenter, Observational, Retrospective-prospective Study Exploring the Clinical Impact of MYC Aberrations and Their Relationship With Microenvironment in Diffuse Large B Cell Lymphoma and High-Grade B Cell Lymphoma","FIL_MIMYC","Inclusion Criteria:\n\n* Diagnosis of nodal and extranodal Diffuse Large B Cell Lymphoma, High Grade B Cell Lymphomas (including low-grade transformed lymphomas; double and triple hit; 11q aberration; not otherwise specified) after 1st January 2019\n* Presence of one MYC translocation or gain of copies (GCN: \\> 3 copies in more than 30% of the nuclei) or amplification evaluated by FISH\n* Availability of immunohistochemical analysis of CD10, Bcl6, MUM1, Bcl2, Myc, Ki67\n* Have received curative treatment (e.g. R-CHOP, R DA EPOCH, intensified \"Burkitt like\" chemotherapies) as first-line therapy\n* Histological material of adequate size and quality to perform histological review with any additional investigations (immunohistochemistry, FISH and other molecular analysis). A FFPE block must be provided for patient enrollment.\n* Age between 18 and 79 years\n\nExclusion Criteria:\n\n* Primary lymphomas of the central nervous system, plasmablastic lymphoma, Burkitt's lymphoma, primary mediastinal B lymphoma\n* Have received palliative treatment","ALL","18 Years","79 Years",{"count":319,"type":320},200,"ESTIMATED","OBSERVATIONAL","This is a observational, retrospective and prospective study designed to assess the potential correlations between MYC alterations, lymphoma mutational landscape and functional immune contextures in Diffuse Large B-cell Lymphoma or High-Grade B-cell Lymphoma",[324,325,326],"Diffuse Large B Cell Lymphoma","High-grade B-cell Lymphoma","High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements",[324,325,328,329,330,331,332,333],"MYC","BCL2","BCL6","Double Hit","Triple Hit","lymphoma micro-environment","2025-12-22",{"date":336,"type":337},"2025-12-29","ACTUAL",{"date":339,"type":337},"2025-05-05",{"date":341,"type":320},"2027-12",{"name":5,"class":6},20]