[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605770":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":51,"collaborators":26,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":26,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":26,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":26,"overallStatus":77,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Leeds Beckett University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nootropic drink","ACTIVE_COMPARATOR","Nootropic beverage containing anthocyanins, L-theanine, and Enzogenol. Administered orally prior to cognitive testing under simulated normobaric hypoxia.",[13],"Dietary Supplement: Nootropics (ginkgo biloba, nicergoline, piracetam, or others)",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo drink","PLACEBO_COMPARATOR","Taste- and appearance-matched placebo beverage without active ingredients. Administered orally prior to cognitive testing under simulated normobaric hypoxia.",[19],"Dietary Supplement: Placebo",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Nootropics (ginkgo biloba, nicergoline, piracetam, or others)","Nootropic drink containing Anthrocyanins, L-theanie and Enzogenol",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo","Taste- and appearance-matched placebo beverage without active ingredients.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Isobel R Harris","CONTACT","+44 7443518358","i.harris@leedsbeckett.ac.uk",[38],{"facility":5,"status":26,"city":39,"state":26,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Leeds","LS6 3QS","United Kingdom","UK",{"type":44,"coordinates":45},"Point",[46,47],-1.54785,53.79648,{"lat":47,"lon":46},[50],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":52,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100605770","exploring-the-cognitive-benefits-of-a-blackcurrant-based-supplement-in-normobaric-hypoxia-100605770",false,"NCT07166835","Exploring the Cognitive Benefits of a Blackcurrant-Based Supplement in Normobaric Hypoxia","The Efficacy of a Blackcurrant-based Nootropic Drink to Support Cognitive Functioning Under Normobaric Simulated High Altitude","Inclusion Criteria:\n\n* Willing and able to provide written informed consent (in English)\n* Aged 18-35\n* Male\n* Residing at a low altitude (\\\u003C500m)\n\nExclusion Criteria:\n\n* Diagnosed food allergy or intolerance to the investigational products or control products. (Blackcurrant, food allergen\u002F pine, tree-derived allergen\u002F l-theanine tree allergen (camellia sinensis))\n* Significant past medical and psychiatric history and ongoing chronic conditions such as, cardiovascular disease, respiratory disease, endocrine disorder (e.g. Diabetes mellites) and neurological and psychiatric conditions including brain injury or are colourblind.\n* Significant medication history or current prescription of medication or supplements known to affect cognition such as. Sedatives, stimulants, or herbal supplements high in anthocyanin and polyphenol content.\n* A positive result from the pre-screening sickle cell trait blood test.\n* An abnormal ECG reading.\n* A resting heart rate above 100bmp.\n* A blood pressure reading above 140\u002F90mmHg.\n* Subjects not willing and\u002F or not able to comply with the scheduled visits required for the study.\n* Not willing to provide blood samples.\n* Not classified as low risk based on the ACSM guidelines.",true,"MALE","18 Years","35 Years",{"count":65,"type":66},27,"ESTIMATED","INTERVENTIONAL",[69],"NA","This study investigates the cognitive effects of Ārepa, a blackcurrant-based drink, under simulated high-altitude conditions (4,500m normobaric hypoxia for \\~180 minutes). Using a double-blind, randomised, placebo-controlled crossover design, participants will consume either the nootropic blackcurrant-based drink or a taste-matched placebo. Cognitive testing (\\~80 minutes) includes Trail-making, Stroop, N-back, Serial 7s\u002F3s, and RVIP tasks. Physiological measures (heart rate, SpO₂, blood) and biomarkers (MAO-B, BDNF, hsCRP, S100B, Prolactin, C3G, Sarmentosin) will be assessed. Scales will evaluate mood, wellbeing, and perceived effects. The aim is to determine if the nootropic drink can support cognitive function in hypoxic environments.",[72,73,74,75,76],"Cognitive Performance","Executive Function (Cognition)","Working Memory","Hypoxia Induced Cognitive Impairment","Mood","NOT_YET_RECRUITING","2025-09-03",{"date":80,"type":81},"2025-09-10","ACTUAL",{"date":83,"type":66},"2025-09-01",{"date":85,"type":66},"2027-10-01",{"name":5,"class":6},1]