[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100548292":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":20,"locations":25,"responsibleParty":41,"collaborators":45,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":10,"eligibilityCriteria":60,"healthyVolunteers":61,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":28,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Xuanwu Hospital, Beijing","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"dementia progression",null,"dementia-P (Compared with the baseline, MMSE score declined ≥ 4 points per year)",{"label":13,"type":10,"description":14,"interventionNames":10},"dementia stabilization","dementia-S (Compared with the baseline, MMSE score decreased \\\u003C 4 points per year）",[16],{"name":17,"affiliation":18,"role":19},"Cuibai Wei","Xuan Wu Hospital of Capital Medical University, Beijing, China, 100053","PRINCIPAL_INVESTIGATOR",[21],{"name":17,"role":22,"phone":23,"phoneExt":10,"email":24},"CONTACT","83198319","weicb@xwhosp.org",[26],{"facility":27,"status":28,"city":29,"state":10,"zip":10,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":38},"Capital Medical University Xuanwu Hospital","RECRUITING","Beijing","China","CN",{"type":33,"coordinates":34},"Point",[35,36],116.39723,39.9075,{"lat":36,"lon":35},[39],{"name":40,"role":22,"phone":10,"phoneExt":10,"email":10},"Cuibai Wei, Ph.D",{"type":42,"investigatorFullName":43,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Cuibai Wei，Clinical Professor","Xuanwu Hospital, Capital Medical University",[46,48,50,52],{"name":47,"class":6},"First Hospital of Shijiazhuang City",{"name":49,"class":6},"Chongqing Medical University",{"name":51,"class":6},"Tianjin Huanhu Hospital",{"name":53,"class":6},"Qianfoshan Hospital","100548292","exploring-the-diagnostic-biomarkers-of-cognitive-disorders-in-china-100548292",false,"NCT06419101","Exploring the Diagnostic Biomarkers of Cognitive Disorders in China","Cohort Study on Biomarkers of Cognitive Disorders in China","Inclusion Criteria:\n\n* Male or female patients aged ≥40 and ≤90years;\n* Chief complaint or others describe a cognitive decline;\n* Ability to communicate in Chinese;\n* The patients and their families were informed and signed the informed consent.\n\nExclusion Criteria:\n\n* MMSE\\\u003C10;\n* There are other neurological diseases that can cause brain dysfunction (such as depression, brain tumors, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, traumatic brain injury, normal intracranial pressure hydrocephalus, etc.);\n* There are other systemic diseases that can cause cognitive impairment (such as hepatic insufficiency, renal insufficiency, Thyroid dysfunction, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.);\n* Suffering from a disease that cannot cooperate with the completion of cognitive examination;\n* There are contraindications to nuclear magnetic resonance;\n* There is mental and neurodevelopmental delay;\n* Refuse to draw blood;\n* Refuse to sign the informed consent.",true,"ALL","40 Years","90 Years",{"count":66,"type":67},3000,"ESTIMATED","OBSERVATIONAL","Dementia is a syndrome characterized by progressive global cognitive impairment that impairs occupational, family, or social functioning. It detrimentally affects personal health and quality of life, imposing significant medical economy, social and psychological burden on the countries and the patients' family. The internationally renowned dementia cohort includes the DIAN that focused on genetics studies, the ADNI cohort featuring imaging and the FINGERS cohort focused on risk factor intervention, etc. Establishing standardized and shared longitudinal follow-up dementia cohorts and clinical database is an essential challenge for constructing dementia cohort in China. Moreover, there is a lack of large-scale prospective longitudinal follow-up cohorts within the Chinese population that cover subjective cognitive decline (SCD) to explore biomarkers with diagnostic and early warning value for different kinds of dementia and pre-dementia stages. The study will rely on the dementia cohort based on Chinese population to explore the biological phenotype characteristics of the pre-dementia stage and different dementia subtypes, and observe the dynamic change rules of the dementia cohort vertically, so as to foster early intervention and improve prognosis for individuals with dementia.",[71,72],"Biomarkers","Dementia",[74,75],"dementia","diagnostic biomarkers","2024-11-12",{"date":78,"type":79},"2024-11-14","ACTUAL",{"date":81,"type":79},"2024-05-30",{"date":83,"type":67},"2035-05-10",{"name":43,"class":6},1]