[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615153":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":49,"centralContacts":54,"locations":62,"responsibleParty":79,"collaborators":36,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":36,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":90,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":36,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":36,"overallStatus":65,"whyStopped":36,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":111},{"fullName":5,"class":6},"National Cheng Kung University","OTHER",[8,17,22,26],{"label":9,"type":10,"description":11,"interventionNames":12},"healthy","EXPERIMENTAL","We will provide BFR combined with exercise",[13,14,15,16],"Behavioral: Aerobic exercise","Behavioral: Blood flow restriction","Behavioral: Resistance exercise","Behavioral: Disease and exercise suggestion",{"label":18,"type":19,"description":20,"interventionNames":21},"CKD usual care group","ACTIVE_COMPARATOR","We will provide patient education, home-based moderate to low-intensity rehabilitation",[16],{"label":23,"type":19,"description":24,"interventionNames":25},"CKD traditional rehabilitation group","We will provide aerobic exercise, resistance exercise training, and patient education",[13,15,16],{"label":27,"type":10,"description":28,"interventionNames":29},"CKD BFR group","We will provide BFR combined with exercise and patient education",[13,14,15],[31,37,41,45],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"BEHAVIORAL","Aerobic exercise","The aerobic exercise intervention will utilize stationary bike. The program will be conducted 2 times per week over a 12 weeks",[27,23,9],null,{"type":32,"name":38,"description":39,"armGroupLabels":40,"otherNames":36},"Blood flow restriction","Blood flow restriction intervention will combined aerobic exercise and resistance exercise. The program will be conducted 2 times per week over a 12 weeks",[27,9],{"type":32,"name":42,"description":43,"armGroupLabels":44,"otherNames":36},"Resistance exercise","The resistance exercise will bilateral leg extension. The program will be conducted 2 times per week over a 12 weeks",[27,23,9],{"type":32,"name":46,"description":47,"armGroupLabels":48,"otherNames":36},"Disease and exercise suggestion","The participants will received self-care technique and home-based exercise approach",[23,18,9],[50],{"name":51,"affiliation":52,"role":53},"Kun-Ling Tasi, PhD","Department of Physical Therapy, National Cheng Kung University","PRINCIPAL_INVESTIGATOR",[55,59],{"name":51,"role":56,"phone":57,"phoneExt":36,"email":58},"CONTACT","886-6-2353535 Ext.5078","Kunlingtsai@mail.ncku.edu.tw",{"name":60,"role":56,"phone":57,"phoneExt":36,"email":61},"Ting-Ying Wu, B.S","t66131036@gs.ncku.edu.tw",[63],{"facility":64,"status":65,"city":66,"state":36,"zip":67,"country":68,"countryCode":69,"cosmosGeoPoint":70,"geoPoint":75,"contacts":76},"National Cheng Kung University Hospital","RECRUITING","Tainan","701","Taiwan","TW",{"type":71,"coordinates":72},"Point",[73,74],120.21333,22.99083,{"lat":74,"lon":73},[77],{"name":51,"role":56,"phone":78,"phoneExt":36,"email":58},"062353535 Ext. 6219",{"type":53,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":36,"oldOrganization":36},"Kun-Ling Tsai","Professor and Chair, Department of Physical Therapy","100615153","exploring-the-effects-of-exercise-combined-with-bfrt-on-healthy-and-patients-with-ckd-100615153",false,"NCT07288905","Exploring the Effects of Exercise Combined With BFRT on Healthy and Patients With CKD","The Feasibility and Effects of Exercise Training Combined With Blood Flow Restriction Training on Exercise Capacity and Exercise Tolerance in Patients With Chronic Kidney Disease","Healthy\n\nInclusion Criteria:\n\n• Aged 20\\~85 years old\n\nExclusion Criteria:\n\n* Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)\n* Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)\n* Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months\n* Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)\n* Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \\>100 bpm)\n* Prone to bruising\n* Recent inflection \\\u003C 1 month\n* Pregnancy\n* Kidney function impairment\n* Cancer\n* Simultaneously participating in other research\n\nCKD\n\nInclusion criteria:\n\n* Aged 20\\~85 years old\n* eGFR\\\u003C 90 ml\u002Fmin\u002F1.73 m2 over 3 months\n* Stable condition without worsening in the past 3 months\n* Ability to understand and follow verbal commends and cooperate with an exercise training program\n\nExclusion criteria:\n\n* Severe uncontrolled metabolic diseases (e.g., hyperthyroidism, diabetes, hypertension, hyperlipidemia, etc.)\n* Severe pulmonary or cardiovascular diseases (e.g., pulmonary hypertension, chronic obstructive pulmonary disease (COPD), heart failure, cardiac arrhythmia)\n* Presence of a cardiac pacemaker or a history of myocardial infarction within the past six months\n* Severe musculoskeletal or neuromuscular disorders (e.g., advanced arthritis, limb amputation, post-polio syndrome, Parkinson's disease)\n* Unstable vital signs (e.g., systolic blood pressure ≥180 mmHg, diastolic blood pressure ≥90 mmHg, requiring vasopressors, or resting heart rate \\>100 bpm)\n* Abnormal blood biochemical parameters (e.g., white blood cell count \\\u003C2500\u002Fmm³, hemoglobin \\\u003C8 mg\u002FdL, total bilirubin \\>3 mg\u002FdL, liver enzymes (GOT\u002FAST, GPT\u002FALT) \\>3 times the upper limit of normal, platelet count \\\u003C75,000\u002Fmm³\n* Sensory or motor dysfunctions that affect walking ability\n* Diagnosed systemic diseases under ongoing treatment (e.g., systemic lupus erythematosus, cancer, malignancies).",true,"ALL","20 Years","85 Years",{"count":94,"type":95},120,"ESTIMATED","INTERVENTIONAL",[98],"NA","Investigate the effects of exercise training on the cardiopulmonary function and exercise capacity in healthy and CKD patients",[101],"Chronic Kidney Disease","2025-12-03",{"date":104,"type":105},"2025-12-17","ACTUAL",{"date":107,"type":105},"2025-10-04",{"date":109,"type":95},"2030-12-31",{"name":5,"class":6},1]