[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100560732":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":35,"locations":43,"responsibleParty":60,"collaborators":63,"id":73,"slug":74,"hasResults":75,"nctId":76,"briefTitle":77,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":75,"sex":80,"minAge":81,"maxAge":82,"enrollmentInfo":83,"targetDuration":25,"studyType":86,"phases":87,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"Heidelberg University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"cardiovascular training","EXPERIMENTAL","The experimental group will perform a cardiovascular training three times a week over 12 weeks.",[13],"Behavioral: cardiovascular training",{"label":15,"type":16,"description":17,"interventionNames":18},"stretching","ACTIVE_COMPARATOR","The active control group will perform a stretching training three times a week over 12 weeks.",[19],"Behavioral: stretching",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Cardiovascular training will be performed in supervised sessions and in small groups of 2-5 persons at the study site. The training is performed on a cycle ergometer at 60% of peak power output (Wmax) for 30 min (i.e., 5 min warm-up, 20 min at 60% Wmax, 5 min cool-down) three times a week for twelve weeks. The exercise program will be increased by 5 min (max. 55 min) and 5% of intensity (in Watt) every two weeks. If participants report a too low (i.e., Borg scale ≤ 11) or too high (i.e., Borg scale ≥ 16) subjective rate of perceived exertion (RPE; Borg scale 6-20) intensity will be increased or decreased until the target levels are met (i.e., Borg scale 12-15). During training, heart rate, intensity (in Watt) and RPE will be monitored. Participants missing training sessions will be offered an additional week to perform up to three training sessions.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"The stretching training will be performed in supervised sessions and in small groups of 2-5 persons at the study site. Stretching training consists of lying, seated, and standing flexibility exercises (according to the recommendations of the American Parkinson´s Disease Foundation and the Parkinson Society Canada) for 30 min (i.e., 5 min warm-up, 20 min main part, 5 min cool-down) three times a week for twelve weeks. The exercise program will be increased by 5 min (i.e., adding additional repetitions and exercises; max. 55 min) every two weeks. Intensity of stretching exercises will be assessed by subjective rate of perceived muscle tension on a visual analog scale (VAS) from 0 to 10 and will be moderate defined as 5 to 7 on the VAS. During training VAS, heart rate, and RPE will be monitored. Participants missing training sessions will be offered an additional week to perform up to three training sessions.",[15],[30,33],{"name":31,"affiliation":5,"role":32},"Simon Steib, Prof. Dr.","PRINCIPAL_INVESTIGATOR",{"name":34,"affiliation":5,"role":32},"Philipp Wanner, Dr.",[36,40],{"name":31,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","+49 6221\u002F544643","simon.steib@issw.uni-heidelberg.de",{"name":34,"role":37,"phone":41,"phoneExt":25,"email":42},"+49 6221\u002F544633","philipp.wanner@issw.uni-heidelberg.de",[44],{"facility":5,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Heidelberg","Baden-Wurttemberg","69120","Germany","DE",{"type":52,"coordinates":53},"Point",[54,55],8.69079,49.40768,{"lat":55,"lon":54},[58,59],{"name":31,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":34,"role":37,"phone":41,"phoneExt":25,"email":42},{"type":32,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Simon Steib","Prof. Dr.",[64,66,68,70],{"name":65,"class":6},"German Foundation for Neurology",{"name":67,"class":6},"University Hospital Heidelberg",{"name":69,"class":6},"Universitätsmedizin Mannheim",{"name":71,"class":72},"SRH Kurpfalzkrankenhaus Heidelberg","UNKNOWN","100560732","exploring-the-effects-of-exercise-on-memory-and-cognition-in-parkinsons-disease-100560732",false,"NCT06580977","Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease","EMCo","Inclusion Criteria:\n\n* Diagnosed Parkinson's disease\n* Disease stage ≤3 on the Hoehn \\& Yahr scale\n* Age ranging from 50 - 80 years\n* Naive to the memory tasks (primary outcomes)\n* Ability to stand and walk at least 10 meters independently\n\nExclusion Criteria:\n\n* Atypical Parkinsonism\n* Significant level of cognitive impairment (i.e., Montreal Cognitive Assessment \\\u003C21)\n* Deep brain stimulation or brain pacemaker\n* Diagnosed psychiatric illness\n* Known clinically relevant neurological, internal or orthopedic conditions besides Parkinsonism that would interfere with the exercise paradigm\n* Exceeding the recommended level of cardiovascular exercise for older adults (i.e., cardiovascular exercise done ≥150 min per week of moderate-intensity or ≥75 min per week of vigorous-intensity)","ALL","50 Years","80 Years",{"count":84,"type":85},60,"ESTIMATED","INTERVENTIONAL",[88],"NA","The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease. Participants will be randomly allocated to one of two groups either performing cardiovascular training (experimental group) or stretching (control group) for twelve weeks, three times a week. The primary aim is to examine whether moderate-intense cardiovascular training (MICT) improves procedural memory formation (primary outcome) compared to stretching. Secondary outcomes include episodic memory formation, cognitive function, cardiorespiratory fitness, sleep quality, and brain-derived neurotrophic factor (BDNF) blood concentration levels.",[91],"Parkinson Disease",[93,94,9,95,96,97,98,99,100,101,102,103,104,105],"Parkinson's Disease","rehabilitation","aerobic exercise","neuroplasticity","memory","encoding","consolidation","motor learning","acquisition","retention","cognition","sleep","brain-derived neurotrophic factor","2024-08-28",{"date":108,"type":109},"2024-08-30","ACTUAL",{"date":111,"type":109},"2024-02-27",{"date":113,"type":85},"2027-07",{"name":5,"class":6},1]