[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100619580":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":12,"centralContacts":35,"locations":41,"responsibleParty":57,"collaborators":12,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":63,"acronym":12,"eligibilityCriteria":64,"healthyVolunteers":61,"sex":65,"minAge":66,"maxAge":12,"enrollmentInfo":67,"targetDuration":12,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":79,"overallStatus":83,"whyStopped":12,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Kaohsiung Medical University Chung-Ho Memorial Hospital","OTHER",[8,13,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo Comparator","NO_INTERVENTION","Routine care without interventional measures",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Experimental Group 1 (oral administration of magnesium ions)","EXPERIMENTAL","Take one packet of oral magnesium ions (400mg) daily",[18],"Dietary Supplement: oral magnesium ions",{"label":20,"type":15,"description":21,"interventionNames":22},"Experimental Group 2 (oral administration of magnesium ions + foot soak in magnesium ion solution)","oral magnesium ions (400 mg) daily, and soak your feet in warm water containing soapberry magnesium ions",[23],"Combination Product: oral magnesium ions and warm water with Gu Bao Sapindus mukorossi magnesium ion solution",[25,30],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":12},"DIETARY_SUPPLEMENT","oral magnesium ions","Take one packet of oral magnesium ions (400 mg) daily for 3 months until the end of the 6th chemotherapy session.",[14],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":12},"COMBINATION_PRODUCT","oral magnesium ions and warm water with Gu Bao Sapindus mukorossi magnesium ion solution","Take one packet of oral magnesium ions (400 mg) daily, and soak your feet in warm water containing soapberry magnesium ions for 10-15 minutes, continuing for 3 months until the end of the 6th chemotherapy session.",[20],[36],{"name":37,"role":38,"phone":39,"phoneExt":12,"email":40},"Chia Yu Lin","CONTACT","886937278050","loveshe992000@gmail.com",[42],{"facility":5,"status":12,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Kaohsiung City","Sanmin District","807378","Taiwan","TW",{"type":49,"coordinates":50},"Point",[51,52],120.31333,22.61626,{"lat":52,"lon":51},[55],{"name":37,"role":38,"phone":56,"phoneExt":12,"email":40},"886-937278050",{"type":58,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100619580","exploring-the-effects-of-magnesium-ions-on-peripheral-neuropathy-serum-magnesium-ion-concentrationsleep-quality-and-quality-of-life-in-patients-with-colorectal-cancer-receiving-chemotherapy-100619580",false,"NCT07346469","Exploring the Effects of Magnesium Ions on Peripheral Neuropathy, Serum Magnesium Ion Concentration,Sleep Quality, and Quality of Life in Patients With Colorectal Cancer Receiving Chemotherapy.","Inclusion Criteria:\n\n* a. Patients diagnosed with colorectal cancer by pathology.\n* b. Age ≥ 20 years.\n* c. Conscious.\n* d. Able to communicate fluently in Mandarin and Taiwanese.\n* e. Patients who have received or are expected to begin chemotherapy (Oxaliplatin).\n\nExclusion Criteria:\n\n* a. ECOG (Eastern Cooperative Oncology Group) ≥2 points.\n* b. Patients receiving intravenous nutrition.\n* c. Patients with pre-existing neuropathy.\n* d. Patients with skin wounds.\n* e. Patients with implanted pacemakers.\n* f. Patients with phenylketonuria.\n* g. Patients with diarrhea.\n* h. Patients with renal insufficiency.\n* i. Patients with hypermagnesemia.\n* j. Patients allergic to any of the ingredients","ALL","20 Years",{"count":68,"type":69},75,"ESTIMATED","INTERVENTIONAL",[72],"NA","Chemotherapy for colorectal cancer (CRC) is frequently complicated by chemotherapy-induced peripheral neuropathy (CIPN) and impaired sleep quality, significantly impacting patient quality of life. Low magnesium levels have been implicated in peripheral nerve dysfunction. This interventional study aims to investigate the effects of magnesium supplementation on serum magnesium concentration, CIPN severity, and sleep quality in CRC patients undergoing chemotherapy.\n\nStudy Design and Methods\n\nThis is a prospective, parallel-group, randomized controlled trial (RCT) utilizing a longitudinal design. Participants (CRC patients undergoing chemotherapy) will be randomly allocated to one of three groups:\n\n* Experimental Group 1: Oral magnesium (400mg) supplementation.\n* Experimental Group 2: Oral magnesium (400mg}) supplementation and magnesium solution foot baths.\n* Control Group: Standard care.\n\nMeasurements will be collected using structured questionnaires and blood samples during each chemotherapy cycle. The primary outcomes will be assessed using:\n\n* Serum Magnesium Concentration\n* CIPN Severity: Functional Assessment of Cancer Therapy\u002FGynecologic Oncology Group-neurotoxicity (FACT\u002FGOG-Ntx) scale.\n* Sleep Quality: Verran and Snyder-Halpern Sleep Scale (VSH). Primary Research Questions (Hypotheses)\n\n  1. Can the magnesium intervention (oral and\u002For foot baths) effectively increase the serum magnesium concentration in CRC patients?\n  2. Can the magnesium intervention alleviate or improve the severity of CIPN?\n  3. Can the magnesium intervention improve the sleep quality of CRC patients during chemotherapy? The intervention groups will be compared against the control group to determine if the magnesium interventions lead to superior improvement in the measured outcomes.",[75,76,77,78],"Colorectal Cancer (CRC)","Chemotherapy Induced Peripheral Neuropathy (CIPN)","Sleep Quality","Quality of Life (QOL)",[80,81,77,82],"Colorectal cancer (CRC)","Chemotherapy induced peripheral neuropathy (CIPN)","Quality of life (QOL)","NOT_YET_RECRUITING","2026-01-07",{"date":86,"type":87},"2026-01-16","ACTUAL",{"date":89,"type":69},"2026-01-01",{"date":91,"type":69},"2028-12-31",{"name":5,"class":6},1]