[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100582271":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":26,"responsibleParty":45,"collaborators":26,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":49,"sex":55,"minAge":56,"maxAge":26,"enrollmentInfo":57,"targetDuration":26,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":71,"whyStopped":26,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":26},{"fullName":5,"class":6},"Universitätsklinikum Hamburg-Eppendorf","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Placebo","PLACEBO_COMPARATOR","regular treatment of pouchitis with consecutive application of antibiotics and probiotics, followed by placebo.",[13],"Other: Placebo",{"label":15,"type":16,"description":17,"interventionNames":18},"Intervention","EXPERIMENTAL","regular treatment of pouchitis with consecutive application of antibiotics and probiotics, additional supplementation of tryptophan (25mg\u002Fkg bodyweight)",[19],"Dietary Supplement: Tryptophan 25mg\u002Fkg bodyweight",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Tryptophan 25mg\u002Fkg bodyweight","Tryptophan is supplemented during the treatment of chronic pouchitis with pro- and antibiotics",[15],null,{"type":6,"name":9,"description":28,"armGroupLabels":29,"otherNames":26},"standard treatment of chronic pouchitis using pro- and antibiotics.",[9],[31],{"name":32,"affiliation":33,"role":34},"Samuel Huber, Prof. Dr. med.","Universitätsklinkum Hamburg-Eppendorf, I. Medizinische Klinik und Poliklinik","PRINCIPAL_INVESTIGATOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Franziska J Stallbaum, Dr. med.","CONTACT","040741053863","f.stallbaum@uke.de",{"name":42,"role":38,"phone":43,"phoneExt":26,"email":44},"Zehra Oguz-Cöloglu","0049741053910","z.oguz-coeloglu@uke.de",{"type":46,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100582271","exploring-the-influence-of-trptophan-on-the-treatment-of-pouchitis-100582271",false,"NCT06861140","Exploring the Influence of Trptophan on the Treatment of Pouchitis","Untersuchung Des Einflusses Einer Tryptophanreichen Diät Auf Das Therapeutische Potential Von Probiotika Nach Antibiotischer Therapie Bei Chronischer Pouchitis (Try Pro Pouch). Eine Prospektive Randomisierte Kontrollierte Doppelblinde Interventionsstudie","TryProPouch","Inclusion Criteria:\n\n* Pouchitis (PDAI \\>= 7)\n* indication for the application of antibiotics and probiotics\n* Age \\>=18 years\n* Informed consent\n\nExclusion Criteria:\n\n* major surgery planned druing the intervention\n* high risk for malnutrition (NRS 2002 \\>=3\u002F BMI \\\u003C18,5 kg\u002Fm\\^2)","ALL","18 Years",{"count":58,"type":59},20,"ESTIMATED","INTERVENTIONAL",[62],"NA","Patients with a pouch frequently suffer from chronic inflammation of the intestinal tract, called pouchitis. Pouchitis is routienly treated with repeated courses of antibiotics and probiotics, which does not stop the inflammation from recurring and exposes the patients to the risk of developing antibiotic -resistant pouchitis. Experimental data suggest that the effectiveness of the antibiotic and probiotic treatment can be prolonged by high consumption of trypotophan, an aminoacid present in everyday food. The Try Pro Pouch study aims to compare the consumption of high amounts of tryptophan against placebo in patients with pouchitis.",[65],"Pouchitis",[65,67,68,69,70],"Antibiotics","Probiotics","Tryptophan","Metabolites","NOT_YET_RECRUITING","2025-03-01",{"date":74,"type":75},"2025-03-06","ACTUAL",{"date":77,"type":59},"2025-04-01",{"date":79,"type":59},"2027-04-30",{"name":5,"class":6}]