[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100593899":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":13,"locations":10,"responsibleParty":19,"collaborators":10,"id":23,"slug":24,"hasResults":25,"nctId":26,"briefTitle":27,"officialTitle":28,"acronym":10,"eligibilityCriteria":29,"healthyVolunteers":25,"sex":30,"minAge":31,"maxAge":32,"enrollmentInfo":33,"targetDuration":10,"studyType":36,"phases":10,"briefSummary":37,"conditions":38,"keywords":40,"overallStatus":44,"whyStopped":10,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":10},{"fullName":5,"class":6},"Sichuan Provincial People's Hospital","OTHER",[8,11],{"label":9,"type":10,"description":10,"interventionNames":10},"Patients with liver cirrhosis scheduled for upper abdominal surgery",null,{"label":12,"type":10,"description":10,"interventionNames":10},"Patients without liver cirrhosis scheduled for upper abdominal surgery",[14],{"name":15,"role":16,"phone":17,"phoneExt":10,"email":18},"Peng Li, MD","CONTACT","86+13668169590","lipengmazui@163.com",{"type":20,"investigatorFullName":21,"investigatorTitle":22,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Peng Li","Deputy Director, Anesthesia and Surgery Center","100593899","exploring-the-mechanisms-of-postoperative-delirium-in-cirrhotic-patients-through-multi-omics-integrative-analysis-100593899",false,"NCT07012434","Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis","Exploring the Mechanisms of Postoperative Delirium in Cirrhotic Patients Through Multi-Omics Integrative Analysis: An Observational Study","Inclusion Criteria:\n\n1. Age: 18-80 years\n2. Patients with or without liver cirrhosis scheduled for upper abdominal surgery due to various clinical indications\n3. Ability to comply with the study protocol and provide informed consent\n\nExclusion Criteria:\n\n1. Comorbid severe cardiac, pulmonary, or renal diseases\n2. Patients with mental status incompatible with study participation, including:\n\n   * Psychiatric disorders\n   * Inability to communicate clearly\n3. Any condition preventing effective communication or cooperation","ALL","18 Years","80 Years",{"count":34,"type":35},133,"ESTIMATED","OBSERVATIONAL","This study looks at memory problems after surgery in people with liver disease. We want to know how often these problems happen and what might cause them. The main question it aims to answer is:\n\n1. Do people with liver disease have more memory problems after stomach surgery than people without liver disease? If yes, how much more often?\n2. Are changes in stomach bacteria and body chemicals related to these memory problems?\n\nWho can join:\n\n* Adults getting stomach surgery\n* Both people with and without liver disease\n\nWhat participants will do:\n\n* Take memory tests before and after surgery\n* Give stool (poop) and blood samples before and after surgery\n\nWhy this matters:\n\nMemory problems after surgery can make recovery harder. If we find that stomach bacteria or body chemicals are involved, doctors might find new ways to prevent these problems in people with liver disease.",[39],"Liver Cirrhosis",[41,42,43],"Postoperative delirium","gut microbiota dysbiosis","metabolomics","NOT_YET_RECRUITING","2025-06-02",{"date":47,"type":48},"2025-06-10","ACTUAL",{"date":50,"type":35},"2025-06-15",{"date":52,"type":35},"2025-10-30",{"name":5,"class":6}]