[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601556":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":18,"centralContacts":19,"locations":25,"responsibleParty":39,"collaborators":18,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":51,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":18,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":66,"whyStopped":18,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Università Vita-Salute San Raffaele","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Behavioral and MR imaging","EXPERIMENTAL","After enrollment, participants will be screened on the basis of the inclusion and exclusion criteria. Subsequently, during the single study, participants will be administered a series of questionnaires (Edinburgh Handedness Inventory - Short Form; Evaluation of social related abilities, competences, and traits: Autism Quotient Test, DASS-21, SIAS, DERS, Ekman test; SET; I-TIPI, and conceptual ratings on semantic dimensions (moral, social, political). Then, an MR acquisition without contrast will be performed. Specifically, we will acquire structural, resting state and functional (BOLD) sequences, in the latter case during the administration of a semantic categorization task. The task is aimed to ascertain participants' responses time and accuracy in processing abstract concepts. Participants will be required to indicate the category of each of the visually presented words by means of button press. The study visit will last 3 hours in total.",[13],"Other: Behavioral and MR scanning",[15],{"type":6,"name":16,"description":11,"armGroupLabels":17,"otherNames":18},"Behavioral and MR scanning",[9],null,[20],{"name":21,"role":22,"phone":23,"phoneExt":18,"email":24},"Jubin Abutalebi, Specialist in Neurology","CONTACT","+39 3494121184","abutalebi.jubin@hsr.it",[26],{"facility":27,"status":18,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":18},"Centro Eccellenza Risonanza Magnetica ad Alto Campo (CERMAC)","Milan","MI","20132","Italy","IT",{"type":34,"coordinates":35},"Point",[36,37],12.59836,42.78235,{"lat":37,"lon":36},{"type":40,"investigatorFullName":41,"investigatorTitle":42,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Jubin Abutalebi","Director Center for Neurolinguistics and Psycholinguistics (CNPL)","100601556","exploring-the-relationship-between-social-expertise-and-ability-to-process-different-types-of-abstract-concepts-and-the-neural-resources-allocated-to-their-processing-100601556",false,"NCT07112027","Exploring the Relationship Between Social Expertise and Ability to Process Different Types of Abstract Concepts and the Neural Resources Allocated to Their Processing","Exploration of the Neural Correlates of Social Expertise: an Fmri Study Comparing Healthy Individuals With Different Levels and Types of Expertise","EXPERTISE-SOC","Inclusion Criteria:\n\n1. Participant is willing and able to give informed consent for participation in the study\n2. Male or female, aged between 25 and 50 years\n3. Right-handed dominance\n4. Normal vision or hypo-vision corrected with contact lenses\n5. Participant must have different levels of social expertise, in order to be assigned to one of the following groups: (1) participants with subclinical social skills dysfunction, parents of children with Autism Spectrum Disorder, (2) participants with no specific social expertise, and (3) participants with high social expertise, namely social media influencers and politicians.\n\nExclusion Criteria:\n\n1. Clinical and\u002For anamnestic evidence of neurological, psychiatric, or systemic disorders\n2. Drug addiction and\u002For abuse of neuroactive drugs;\n3. Contraindications and incompatibilities with MRI, and specifically presence of para-magnetic or ferro-magnetic metal body prostheses; presence of permanent biomedical implants (e.g., pacemakers, neuro-stimulators); pregnancy status; claustrophobia. Pregnancy status will be self-reported by the participants.",true,"ALL","25 Years","50 Years",{"count":56,"type":57},84,"ESTIMATED","INTERVENTIONAL",[60],"NA","Social interaction is supported by several brain regions, which are involved in encoding socio-perceptual information, attributing affective and mental states to other conspecifics, and ultimately enabling the orchestration of an appropriate response. In this view, cognitive control mechanisms are necessary to select relevant information, allocate resources, and generate inferences. There is a close link between the mechanisms underlying social cognition and social conceptual knowledge, relating, for example, to abstract concepts such as \"friendship\". For example, children with autism spectrum disorder (ASD) show impairments in social interactions, and also in the ability to use all those abstract concepts that relate to internal states of the individual as well as to interactions between people.\n\nBehavioral studies have shown how experience can impact the characterization of abstract concepts, influencing their personal, introspective, and contextual characteristics. Neuroimaging studies have also reported that, through mechanisms of brain plasticity, experience modulates neural networks shared with non-experts (e.g., by increasing brain volume and\u002For functional activity), but can also lead to the recruitment of additional brain resources, thus enriching the knowledge gained by experts. To date, the role of different types and levels of expertise in influencing the neural representation of specific categories of abstract concepts, and in particular social concepts, has not yet been fully elucidated.",[63],"Healthy",[65],"volounteers with different levels of social expertise","NOT_YET_RECRUITING","2025-08-05",{"date":69,"type":70},"2025-08-08","ACTUAL",{"date":72,"type":57},"2025-08",{"date":74,"type":57},"2026-02",{"name":5,"class":6},1]