[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599130":3},{"organization":4,"armGroups":7,"interventions":28,"overallOfficials":47,"centralContacts":51,"locations":57,"responsibleParty":75,"collaborators":77,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":85,"acronym":34,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":34,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":60,"whyStopped":34,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},{"fullName":5,"class":6},"University of Bern","OTHER",[8,14,19,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Active Stimulation (Healthy)","EXPERIMENTAL","Healthy adults aged 20 to 40 or 60 to 75 years.",[13],"Device: Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002FF4",{"label":15,"type":16,"description":11,"interventionNames":17},"Sham Stimulation (Healthy)","SHAM_COMPARATOR",[18],"Device: Sham high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002FF4",{"label":20,"type":10,"description":21,"interventionNames":22},"Active Stimulation (Patient)","Patients with mild to moderate depression aged 20 to 40 or 60 to 75 years.",[23],"Device: Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002F kathodal F4",{"label":25,"type":16,"description":21,"interventionNames":26},"Sham Stimulation (Patient)",[27],"Device: Sham high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002F kathodal F4",[29,35,39,43],{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"DEVICE","Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002FF4","Participants receive anodal HD-tDCS targeting the left or right DLPFC (F3\u002FF4).",[9],null,{"type":30,"name":36,"description":37,"armGroupLabels":38,"otherNames":34},"Sham high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002FF4","Participants receive sham HD-tDCS targeting the left or right DLPFC (F3\u002FF4). The device mimics the sensation of stimulation without delivering active current.",[15],{"type":30,"name":40,"description":41,"armGroupLabels":42,"otherNames":34},"Active high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002F kathodal F4","Participants receive anodal HD-tDCS targeting the left DLPFC (F3) and cathodal stimulation targeting the right DLPFC (F4).",[20],{"type":30,"name":44,"description":45,"armGroupLabels":46,"otherNames":34},"Sham high-definition transcranial direct current stimulation (HD-tDCS) - anodal F3\u002F kathodal F4","Participants receive sham HD-tDCS targeting the left DLPFC (F3) and right DLPFC (F4). The device mimics the sensation of stimulation without delivering active current.",[25],[48],{"name":49,"affiliation":5,"role":50},"Jessica Peter, PhD","PRINCIPAL_INVESTIGATOR",[52],{"name":53,"role":54,"phone":55,"phoneExt":34,"email":56},"Maya D Yilmaz, M.Sc.","CONTACT","+41 58 630 79 62","maya.yilmaz@unibe.ch",[58],{"facility":59,"status":60,"city":61,"state":34,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"University of Bern, Department of Old Age Psychiatry and Psychotherapy","RECRUITING","Bern","3000","Switzerland","CH",{"type":66,"coordinates":67},"Point",[68,69],7.44744,46.94809,{"lat":69,"lon":68},[72],{"name":49,"role":54,"phone":73,"phoneExt":34,"email":74},"+41 58 630 89 03","jessica.peter@unibe.ch",{"type":76,"investigatorFullName":34,"investigatorTitle":34,"investigatorAffiliation":34,"oldNameTitle":34,"oldOrganization":34},"SPONSOR",[78],{"name":79,"class":80},"ki:elements","UNKNOWN","100599130","exploring-the-role-of-the-prefrontal-cortex-in-decision-making-100599130",false,"NCT07080489","Exploring the Role of the Prefrontal Cortex in Decision-Making","Inclusion Criteria (Healthy):\n\n* Written Informed Consent\n* Age between 20-40 or 60-75 years\n* Fluent in German\n* Normal or corrected-to-normal vision\n* No color blindness\n* Right-handed\n* Non-smoker\n\nExclusion Criteria (Healthy):\n\n* History of neurological disorders\n* History of psychiatric disorders\n* Use of psychotropic medication\n* Presence of magnetizable implants\n* Alcohol or drug dependence\n\nInclusion Criteria (Patient):\n\n* Written Informed Consent\n* Diagnosed with mild to moderate depression\n* Age between 20-40 or 60-75 years\n* Fluent in German\n* Normal or corrected-to-normal vision\n* No color blindness\n\nExclusion Criteria (Patient):\n\n* Intake of benzodiazepines or antipsychotic medication\n* psychiatric disorders other than depression (e.g., psychosis, mania, personality disorders) or depression with organic cause\n* Presence of magnetizable implants\n* Alcohol or drug dependence",true,"ALL","20 Years","75 Years",{"count":92,"type":93},444,"ESTIMATED","INTERVENTIONAL",[96],"NA","The goal of this study is to examine whether high-definition transcranial direct current stimulation (HD-tDCS) can influence decision-making for emotionally valenced content in younger and older adults, with or without major depression.\n\nThe main questions are:\n\nIn healthy adults, does brain stimulation modulate how people respond to emotionally valenced content during a decision-making task? What happens in the brain during modulation? Do these effects differ between younger and older adults?\n\nIn adults with depression, does brain stimulation help shift attention towards positive content during the task? What happens in the brain? Are these effects moderated by age (younger vs. older adults)?\n\nThe investigators will compare participants who receive real stimulation to those who receive sham (placebo) stimulation.\n\nParticipants will:\n\nReceive high-definition transcranial direct current stimulation (HD-tDCS) of the dorsolateral prefrontal cortex (DLPFC)\n\nPerform a decision-making task involving emotionally valenced words\n\nComplete the task while undergoing a brain scan using ultra-high field 7 Tesla magnetic resonance imaging (MRI) to measure brain activity",[99,100,101],"Depressive Disorder, Major Depressive Disorder","Healthy Volunteer","Aging",[103,104,105,106,107,108,109,101],"UHF fMRI","DLPFC","fMRI","HD-tDCS","Cognitive Control","Noninvasive Brain Stimulation","Depression","2025-07-14",{"date":112,"type":113},"2025-07-23","ACTUAL",{"date":115,"type":113},"2025-03-04",{"date":117,"type":93},"2027-10",{"name":5,"class":6},1]