[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594337":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":12,"centralContacts":40,"locations":49,"responsibleParty":65,"collaborators":12,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":12,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":12,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":52,"whyStopped":12,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Burapha University","OTHER",[8,13,19,25],{"label":9,"type":10,"description":11,"interventionNames":12},"Study 2: control group","NO_INTERVENTION","Participants will not receive any breathing training.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Study 2: deep breathing","ACTIVE_COMPARATOR","Participants will practice deep diaphragmatic breathing at a rate of 6-10 breaths per minute for 15 minutes, twice a day. Participants are required to follow their assigned breathing programs daily for three consecutive months.",[18],"Other: Study 2: deep breathing",{"label":20,"type":21,"description":22,"interventionNames":23},"Study 2: 4-7-8 breathing","EXPERIMENTAL","Participants will practice the 4-7-8 breathing technique, which involves inhaling for 4 seconds, holding the breath for 7 seconds, and exhaling for 8 seconds-this constitutes one cycle. They will repeat this for 6 cycles per set, three sets per day, with normal breathing between sets. Participants are required to follow their assigned breathing programs daily for three consecutive months.",[24],"Other: Study 2: 4-7-8 breathing",{"label":26,"type":15,"description":27,"interventionNames":28},"Study 2: slow breathing with device","Participants will practice deep breathing using a resistance-based breathing device called \"BreathMax\" which provides water pressure resistance set at 25% of their maximum inspiratory capacity. The breathing rate will be set at 6 breaths per minute, continued for 15 minutes per session, twice daily. Participants are required to follow their assigned breathing programs daily for three consecutive months.",[29],"Other: Study 2: slow breathing with device",[31,34,37],{"type":6,"name":14,"description":32,"armGroupLabels":33,"otherNames":12},"Participants in the deep breathing group will be randomized to receive a diaphragmatic deep breathing program. They will be instructed to practice deep breathing at a rate of 6-10 breaths per minute for 15 minutes, twice daily, every day for a duration of 3 months.",[14],{"type":6,"name":20,"description":35,"armGroupLabels":36,"otherNames":12},"Participants in the 4-7-8 breathing group will be randomized to receive a 4-7-8 breathing program. They will follow the 4-7-8 breathing training program, which involves inhaling for 4 seconds, holding the breath for 7 seconds, and exhaling for 8 seconds, counted as one cycle. This pattern is to be repeated for 6 cycles to complete one set. They will perform 12 sets per day-6 sets in the morning and 6 sets in the evening-with normal breathing between each set. This routine will be carried out daily for a duration of 3 months.",[20],{"type":6,"name":26,"description":38,"armGroupLabels":39,"otherNames":12},"Participants in the slow breathing with device group will be randomized to receive a slow breathing with device. They will undergo deep breathing training using a resistance-based breathing device called BreathMax, set at 25% of their maximal inspiratory pressure. The breathing rate will be 6 breaths per minute, continuously for 15 minutes, twice a day. This routine will be performed daily for a duration of 3 months.",[26],[41,46],{"name":42,"role":43,"phone":44,"phoneExt":12,"email":45},"Piyapong Prasertsri, Ph.D.","CONTACT","6638103166","piyapong@buu.ac.th",{"name":47,"role":43,"phone":44,"phoneExt":12,"email":48},"Tadsawiya Padkao, Ph.D.","tadsawiya@go.buu.ac.th",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":12,"geoPoint":12,"contacts":58},"Faculty of Allied Health Sciences, Burapha University","RECRUITING","MueangChonburi","Changwat Chon Buri","20131","Thailand","TH",[59,60,61,63],{"name":42,"role":43,"phone":44,"phoneExt":12,"email":45},{"name":47,"role":43,"phone":44,"phoneExt":12,"email":48},{"name":42,"role":62,"phone":12,"phoneExt":12,"email":12},"PRINCIPAL_INVESTIGATOR",{"name":47,"role":64,"phone":12,"phoneExt":12,"email":12},"SUB_INVESTIGATOR",{"type":62,"investigatorFullName":66,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Piyapong Prasertsri","Associate Professor Dr.","100594337","expression-of-genes-relating-hypertension-and-efficacy-of-4-7-8-breathing-control-on-reducing-blood-pressure-100594337",false,"NCT07018128","Expression of Genes Relating Hypertension and Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure","Expression of Genes Relating Hypertension in Thailand and the Efficacy of 4-7-8 Breathing Control on Reducing Blood Pressure in Individuals With Hypertension","Study 1:\n\n1. Group of individuals with hypertension\n\n   Inclusion Criteria:\n   * Male or female\n   * Aged between 18-59 years\n   * Of Thai ethnicity\n   * Diagnosed with hypertension, defined as having an SBP of 140 mmHg or higher, or a DBP of 90 mmHg or higher, or having previously been diagnosed with hypertension and currently taking antihypertensive medication\n   * Originally from various regions of Thailand and currently residing in the eastern region\n\n   Exclusion Criteria:\n   * Has heart disease, such as valvular stenosis or regurgitation, coronary artery disease, or heart failure\n   * Has obesity, defined as having a body mass index (BMI) of 30 kg\u002Fm² or higher\n   * Has a fever or is currently experiencing an infectious disease, such as COVID-19, the flu, or other infections\n2. Group of individuals with normal blood pressure\n\nInclusion Criteria:\n\n* Male or female\n* Aged between 18-59 years\n* Of Thai ethnicity\n* Does not have hypertension, defined as having an SBP below 130 mmHg and a DBP below 85 mmHg, with no prior diagnosis of hypertension and no history of taking antihypertensive medication\n* Originally from various regions of Thailand and currently residing in the eastern region\n\nExclusion Criteria:\n\n* Has heart disease, such as valvular stenosis or regurgitation, coronary artery disease, or heart failure\n* Has obesity, defined as having a body mass index (BMI) of 30 kg\u002Fm² or higher\n* Has a fever or is currently experiencing an infectious disease, such as COVID-19, the flu, or other infections\n\nStudy 2:\n\nInclusion Criteria:\n\n* Male or female, aged 35-59 years\n* Diagnosed with hypertension, with blood pressure levels above the normal range, defined as SBP of 130 mmHg or higher, or DBP of 85 mmHg or higher, and currently taking medication\n* Originally from various regions of Thailand and currently residing in the eastern region\n* Able to communicate effectively\n\nExclusion Criteria:\n\n* Has respiratory diseases, cardiovascular diseases, cerebrovascular disease, kidney disease, cancer, or immune-related conditions such as allergies, autoimmune diseases (e.g., SLE), immunodeficiency, or rheumatoid arthritis\n* Is obese, defined as having a body mass index (BMI) of 30 kg\u002Fm² or higher\n* Has a fever or is currently infected, such as with COVID-19, the flu, or other infectious diseases\n* Is currently pregnant, breastfeeding, or has a history of pregnancy within the 6 months prior to participating in the study",true,"ALL","18 Years","59 Years",{"count":80,"type":81},200,"ESTIMATED","INTERVENTIONAL",[84],"NA","This study consists of two sub-studies. Study 1 investigates gene expression related to the development of hypertension in Thailand, and Study 2 examines the effectiveness of the 4-7-8 breathing technique in reducing blood pressure in individuals with hypertension.",[87,88],"Genetic Predisposition to Disease","Breathing, Mouth",[90,91,92],"Gene","Blood pressure","Breathing","2026-05-08",{"date":95,"type":96},"2026-05-11","ACTUAL",{"date":98,"type":96},"2024-10-01",{"date":100,"type":81},"2026-09-30",{"name":5,"class":6},1]