[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633952":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":26,"locations":38,"responsibleParty":57,"collaborators":26,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":67,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":70,"minAge":71,"maxAge":26,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":83,"overallStatus":88,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Stanford University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Foot and ankle surgery with standard of care EEG emergence","ACTIVE_COMPARATOR","Participants undergoing routine foot and ankle surgery will be given a routine standard of care intraoperatively at standard Patient Status Index (PSI) readings.",[13],"Procedure: Standard of Care EEG-Guided Emergence",{"label":15,"type":16,"description":17,"interventionNames":18},"Foot and ankle surgery with extended EEG emergence trajectory","EXPERIMENTAL","Participants undergoing routine foot and ankle surgery will be given an experimental EEG emergence trajectory at end-operation held at PSI greater than 50 for a minimum of 5 minutes.",[19],"Procedure: Extended EEG Emergence Trajectory",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Standard of Care EEG-Guided Emergence","Participants in this arm will undergo standard-of-care emergence from general anesthesia, with anesthetic management and timing of emergence determined by the treating anesthesiologist according to usual institutional practice. Continuous frontal EEG monitoring will be available as part of routine intraoperative monitoring; however, anesthetic discontinuation, adjustment of anesthetic dose, and timing of tracheal extubation will not follow a protocolized extended EEG target (for example, there is no requirement to maintain PSI greater than 50 for a predefined duration before extubation).",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Extended EEG Emergence Trajectory","Participants receive protocolized extended emergence guided by continuous frontal EEG monitoring during the final phase of anesthesia. Anesthesiologists will titrate anesthetic dosing to achieve and maintain a pre-specified emergence EEG pattern characterized by a persistent, organized posterior-dominant beta rhythm and return of higher-frequency activity, corresponding to a Patient State Index (PSI) greater than 50 for at least 5 consecutive minutes before tracheal extubation. Standard intraoperative hemodynamic and respiratory management will be maintained per routine care.",[15],[32,35],{"name":33,"affiliation":5,"role":34},"Harrison S Chow, MD, Msc.","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":5,"role":37},"Yuva Krishnapillai, BS","STUDY_DIRECTOR",[39],{"facility":40,"status":26,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Stanford Medicine Outpatient Center","Redwood City","California","94063","United States","US",{"type":47,"coordinates":48},"Point",[49,50],-122.23635,37.48522,{"lat":50,"lon":49},[53,54],{"name":33,"role":34,"phone":26,"phoneExt":26,"email":26},{"name":55,"role":56,"phone":26,"phoneExt":26,"email":26},"Makoto Kawai, MD, Dsc.","SUB_INVESTIGATOR",{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Harrison Shong-Wen Chow","Clinical Professor in Medicine","100633952","extended-emergence-strategy-on-post-anesthesia-care-unit-events-after-outpatient-orthopedic-surgery-100633952",false,"NCT07533370","Extended Emergence Strategy on Post-Anesthesia Care Unit Events After Outpatient Orthopedic Surgery","Extended Emergence Trajectory on Post-Anesthesia Care Units Events in Ambulatory Lower-Extremity Orthopedic Surgery: A Randomized Controlled Trial","PACU-EMERGE","Inclusion Criteria:\n\n* Participants with American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for Elective Foot\u002FAnkle Orthopaedic surgery at Stanford Health under planned propofol-based intravenous anesthesia and regional nerve block for preoperative analgesia\n* Able and willing to complete all cognitive assessments and Brice Interview in PACU\n\nExclusion Criteria:\n\n* ASA physical status IV or V\n* Chronic opioid therapy\n* Chronic benzodiazepine use or ongoing treatment with strongly anticholinergic medications within 30 days prior to surgery.\n* Known major neuro-cognitive disorder, active psychotic disorder, or other severe psychiatric condition that, in the opinion of the investigator, would interfere with valid cognitive testing.\n* Active cardiac or neurological stimulators or pumps in use\n* Severe uncorrected visual or hearing impairment that precludes valid cognitive battery or interview completion.\n* Inability to speak and understand the study language sufficiently to provide informed consent and complete study assessments.\n* Inability to provide informed consent or lack of a legally authorized representative when required.\n* Concurrent participation in another interventional study that could confound PACU cognitive or delirium outcomes.",true,"ALL","18 Years",{"count":73,"type":74},300,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to learn if an extended emergence from anesthesia can improve recovery room (Post-Anesthesia Care Unit or PACU) outcomes in lower-leg or foot surgery with nerve blocks. The primary questions it aims to answer are:\n\n* Does a longer wake-up help participants think more clearly soon after surgery compared with usual approaches?\n* Does it lower pain scores, lower the amount of pain medications used, and shorten the time it takes to go home from recovery room?\n\nResearchers will compare 2 groups of adults who are having similar lower-extremity orthopaedic surgeries with regional and propofol anesthesia.",[80,81,82],"Perioperative Care","EEG Power Spectra","Delirium - Postoperative",[84,85,86,87],"Post-anesthesia care unit (PACU)","Postoperative delirium","EEG-guided anesthesia","Neurocognitive outcomes","NOT_YET_RECRUITING","2026-05-19",{"date":91,"type":92},"2026-05-22","ACTUAL",{"date":94,"type":74},"2026-07",{"date":96,"type":74},"2027-10",{"name":59,"class":6},1]