[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100611543":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":42,"centralContacts":47,"locations":56,"responsibleParty":72,"collaborators":30,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":30,"eligibilityCriteria":81,"healthyVolunteers":77,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":98,"overallStatus":59,"whyStopped":30,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Cukurova University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Paravertebral Block Group","ACTIVE_COMPARATOR","Participants in this arm will receive bilateral paravertebral block after induction of general anesthesia. Under ultrasound guidance, 0.25% bupivacaine (20 mL per side; total 40 mL) will be administered to provide postoperative analgesia following laparoscopic cholecystectomy. Patients will also receive standard intravenous paracetamol postoperatively.",[13],"Procedure: Paravertebral Block (PVB)",{"label":15,"type":10,"description":16,"interventionNames":17},"External Oblique Intercostal Block Group","Participants in this arm will receive bilateral external oblique intercostal (EOI) block after induction of general anesthesia. Under ultrasound guidance, 0.25% bupivacaine (20 mL per side; total 40 mL) will be injected into the fascial plane between the external oblique and intercostal muscles. Standard intravenous paracetamol will be administered postoperatively.",[18],"Procedure: External Oblique Intercostal Block (EOI Block)",{"label":20,"type":10,"description":21,"interventionNames":22},"Control Group - IV PCA Tramadol","Participants in this arm will receive intravenous patient-controlled analgesia (PCA) with tramadol for postoperative pain management. The PCA pump will be set to a maximum dose of 400 mg tramadol in 24 hours. Standard intravenous paracetamol (1 g every 8 hours) will also be administered. No regional anesthesia block will be performed in this group.",[23],"Drug: Tramadol IV Patient-Controlled Analgesia (PCA)",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"PROCEDURE","Paravertebral Block (PVB)","Ultrasound-guided bilateral thoracic paravertebral block performed after induction of general anesthesia using 0.25% bupivacaine, 20 mL per side (total 40 mL).",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"External Oblique Intercostal Block (EOI Block)","Ultrasound-guided bilateral external oblique intercostal block performed after induction of general anesthesia with 0.25% bupivacaine, 20 mL per side (total 40 mL), injected between the external oblique and intercostal muscles.",[15],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":40},"DRUG","Tramadol IV Patient-Controlled Analgesia (PCA)","Intravenous patient-controlled analgesia (PCA) programmed to deliver tramadol with a maximum dose of 400 mg in 24 hours. Standard analgesia protocol includes IV paracetamol 1 g every 8 hours.",[20],[41],"Control group",[43],{"name":44,"affiliation":45,"role":46},"Nurefsan Sadikoglu, MD","Cukurova University Hospital","PRINCIPAL_INVESTIGATOR",[48,52],{"name":44,"role":49,"phone":50,"phoneExt":30,"email":51},"CONTACT","+(90) 538 926 2414","nurefsansadikoglu@gmail.com",{"name":53,"role":49,"phone":54,"phoneExt":30,"email":55},"Zehra Hatipoglu, MD","+(90) 532 447 1670","hatipogluzehra@gmail.com",[57],{"facility":58,"status":59,"city":60,"state":30,"zip":30,"country":61,"countryCode":30,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Cukurova University Faculty of Medicine","RECRUITING","Adana","Turkey (Türkiye)",{"type":63,"coordinates":64},"Point",[65,66],35.32531,36.98615,{"lat":66,"lon":65},[69,71],{"name":44,"role":49,"phone":70,"phoneExt":30,"email":51},"+ (90) 538 926 2414",{"name":53,"role":49,"phone":54,"phoneExt":30,"email":55},{"type":46,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Nurefsan Sadikoglu","Attending Specialist","100611543","external-oblique-intercostal-block-eoicb-for-laparoscopic-cholecystectomy-100611543",false,"NCT07241949","External Oblique Intercostal Block (EOICB) for Laparoscopic Cholecystectomy","Paravertebral Block or External Oblique Intercostal Block? A Comparative Analysis of Pain and Opioid Consumption After Laparoscopic Cholecystectomy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Scheduled for elective laparoscopic cholecystectomy under general anesthesia\n* ASA physical status I-III\n* Able to understand the study procedure and provide informed consent\n\nExclusion Criteria:\n\nPatient refusal or inability to provide informed consent\n\nAllergy or contraindication to local anesthetics, tramadol, or study medications\n\nCoagulopathy or current anticoagulant therapy\n\nLocal infection at the planned block injection site\n\nSevere hepatic or renal impairment\n\nChronic opioid use or opioid dependence\n\nNeurological or psychiatric disorders affecting pain perception or communication\n\nPregnancy or breastfeeding\n\nBody mass index (BMI) \\> 35 kg\u002Fm²\n\nConversion to open cholecystectomy during surgery","ALL","18 Years","65 Years",{"count":86,"type":87},147,"ESTIMATED","INTERVENTIONAL",[90],"NA","This single-center, prospective, randomized controlled trial aims to compare the effects of paravertebral block (PVB), external oblique intercostal (EOI) block, and intravenous patient-controlled analgesia (PCA) with tramadol on postoperative pain and opioid consumption in patients undergoing elective laparoscopic cholecystectomy. The primary endpoint is total tramadol consumption within 24 hours postoperatively. Secondary outcomes include pain scores, additional analgesic use, incidence of nausea\u002Fvomiting, mobilization time, and length of hospital stay.",[93,94,95,96,97],"Postoperative Pain","Laparoscopic Cholecystectomy","Paravertebral Block","External Oblique Intercostal Plane Block","Patient Controlled Analgesia",[99,100,101,102,103],"Cholecystectomy","Pain","Analgesia","Tramadol","Nerve Block","2026-06-30",{"date":106,"type":107},"2026-07-02","ACTUAL",{"date":109,"type":107},"2025-12-01",{"date":111,"type":87},"2026-12-05",{"name":5,"class":6},1]