[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100621595":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":11,"centralContacts":19,"locations":27,"responsibleParty":72,"collaborators":10,"id":75,"slug":76,"hasResults":77,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":77,"sex":83,"minAge":84,"maxAge":10,"enrollmentInfo":85,"targetDuration":10,"studyType":88,"phases":10,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"University of Thessaly","OTHER",[8],{"label":9,"type":10,"description":10,"interventionNames":10},"Patients undergoing weaning",null,[12,16],{"name":13,"affiliation":14,"role":15},"Apostolos - Alkiviadis Menis","General University Hospital of Larissa","PRINCIPAL_INVESTIGATOR",{"name":17,"affiliation":5,"role":18},"Demosthenes Makris","STUDY_DIRECTOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Apostolos - Alkiviadis Menis, MD, PhD","CONTACT","+30 2413501280","menis.ap.alk@gmail.com",{"name":17,"role":22,"phone":23,"phoneExt":10,"email":26},"dimomakris@med.uth.gr",[28,44,60],{"facility":14,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":33,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Larissa","41110","Greece","GR",{"type":35,"coordinates":36},"Point",[37,38],22.42112,39.62847,{"lat":38,"lon":37},[41,42],{"name":13,"role":22,"phone":23,"phoneExt":10,"email":24},{"name":43,"role":15,"phone":10,"phoneExt":10,"email":10},"Apostolos Alkiviadis Menis",{"facility":45,"status":46,"city":47,"state":10,"zip":48,"country":32,"countryCode":33,"cosmosGeoPoint":49,"geoPoint":53,"contacts":54},"AHEPA - University General Hospital","NOT_YET_RECRUITING","Thessaloniki","54636",{"type":35,"coordinates":50},[51,52],22.93493,40.64072,{"lat":52,"lon":51},[55,59],{"name":56,"role":22,"phone":57,"phoneExt":10,"email":58},"Anna Gkiouliava","+30 2310 993 262","annagkio@gmail.com",{"name":56,"role":15,"phone":10,"phoneExt":10,"email":10},{"facility":61,"status":46,"city":47,"state":10,"zip":62,"country":32,"countryCode":33,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"General Hospital of Thessaloniki \"G. Papanikolaou\"","57010",{"type":35,"coordinates":64},[51,52],{"lat":52,"lon":51},[67,71],{"name":68,"role":22,"phone":69,"phoneExt":10,"email":70},"Christos Karachristos","+30 2313307268","christosk2004@yahoo.gr",{"name":68,"role":15,"phone":10,"phoneExt":10,"email":10},{"type":15,"investigatorFullName":73,"investigatorTitle":74,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"DEMOSTHENES MAKRIS","Professor of Intensive Care, Director of the Department of Intensive Care, General University Hospital of Larissa","100621595","external-validation-of-vvi-100621595",false,"NCT07372664","External Validation of VVI","External Validation of the Volume-Velocity Index for Weaning Prediction: a Multicenter Observational Study","E-VVI","Inclusion Criteria:\n\n* Mechanically ventilated patients for more than 48h\n* First Spontaneous breathing trial\n* Deemed as ready to undergo weaning by the treating physician, according to published readiness criteria (DOI: 10.1183\u002F09031936.00010206)\n\nExclusion Criteria:\n\n* pregnant patients\n* preexisting diaphragmatic disease or injury\n* tracheostomy","ALL","18 Years",{"count":86,"type":87},100,"ESTIMATED","OBSERVATIONAL","Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation.\n\nIn this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases:\n\n1. during pressure support ventilation with 5\u002F5,\n2. during pressure support ventilation with 8\u002F0,\n3. during t-tube or pressure support ventilation with 0\u002F0. All of these phases are ventilatory modalities widely used during weaning from mechanical ventilation.\n\nThe investigators will evaluate whether VVI can predict accurately the weaning outcome.",[91],"Weaning Mechanical Ventilation",[93,94,95],"weaning","mechanical ventilation","ultrasound","2026-02-08",{"date":98,"type":99},"2026-02-11","ACTUAL",{"date":101,"type":99},"2025-12-28",{"date":103,"type":87},"2026-09",{"name":5,"class":6},3]