[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100644791":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":23,"responsibleParty":38,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":10,"enrollmentInfo":50,"targetDuration":10,"studyType":53,"phases":10,"briefSummary":54,"conditions":55,"keywords":10,"overallStatus":26,"whyStopped":10,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"Charite University, Berlin, Germany","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"HTx patients",null,"This study will include patients actively listed for heart transplantation (HTx) and patients who are still hospitalized following HTx surgery.",[13],{"name":14,"affiliation":15,"role":16},"Felix Schoenrath, Prof","Charité Universitaetsmedizin Berlin","PRINCIPAL_INVESTIGATOR",[18],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Laurenz Kopp Fernandes","CONTACT","+49 (0)30 4593 2154","laurenz.koppfernandes@dhzc-charite.de",[24],{"facility":25,"status":26,"city":27,"state":28,"zip":29,"country":30,"countryCode":31,"cosmosGeoPoint":32,"geoPoint":37,"contacts":10},"Deutsches Herzzentrum der Charité, Department vor cardio-thoracic and vascular surgery","RECRUITING","Berlin","State of Berlin","13353","Germany","DE",{"type":33,"coordinates":34},"Point",[35,36],13.41053,52.52437,{"lat":36,"lon":35},{"type":39,"investigatorFullName":19,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Dr.","100644791","extracellular-vesicles-for-rejection-monitoring-in-cardiac-transplantation-100644791",false,"NCT07673536","Extracellular Vesicles for Rejection Monitoring in Cardiac Transplantation","ExoRejeCT","Inclusion Criteria:\n\n* Subject is either on the heart transplant waiting list or is still hospitalised following HTx surgery.\n* Age of subject is ≥ 18 years.\n* Subject is female or male.\n* Capacity to consent.\n* Signed written informed consent.\n* For female subjects:\n\n  1. Confirmed post-menopausal state, defined as amenorrhea for at least 12 months, or\n  2. If being of childbearing potential: Negative highly sensitive urine or serum pregnancy test before inclusion.\n\nExclusion Criteria:\n\n* Concurrent multiple solid organ or tissue transplants.\n* Prior history of any organ or cellular transplantation.\n* Subject suffers from an addiction or from a disease that prevents the subject from recognising nature, scope, and consequences of the study.\n* Subject shows an inability to comply with all the study procedures and follow-up visits.\n* Subject is legally detained in an official institution.\n* Subjects who are unwilling to consent to saving and propagation of pseudonymised medical data for study reasons.\n* Subject is financially dependent on the investigators or the study site.","ALL","18 Years",{"count":51,"type":52},30,"ESTIMATED","OBSERVATIONAL","This study will analyze extracellular vesicle (EV)-derived protein profiles in heart transplantated patients during the first 15 months post-transplantation to investigate, if there are distinct EV-derived proteins or protein patterns that allow early and reliable diagnosis of acute cardiac allograft rejection. Additionally, it will explore temporal changes in the EV-derived protein profile during the early postoperative period irrespective of acute allograft rejection, and will investigate, if there are correlations between EV protein markers and imaging findings.",[56],"Rejection Heart Transplant","2026-06-30",{"date":59,"type":60},"2026-07-01","ACTUAL",{"date":62,"type":60},"2026-06-18",{"date":64,"type":52},"2028-11-30",{"name":19,"class":6},1]