[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636200":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":37,"centralContacts":42,"locations":52,"responsibleParty":66,"collaborators":46,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":46,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":46,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":103,"whyStopped":46,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Fatih Sultan Mehmet Training and Research Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Eyelid Taping Alone","ACTIVE_COMPARATOR","Patients receive hypoallergenic surgical tape applied horizontally across the tarsal plate of both eyes immediately after anesthesia induction and loss of lid reflex. No lubricant eye drops or ointment are applied. Tape remains in place until extubation is complete.",[13],"Procedure: Hypoallergenic Eyelid Taping",{"label":15,"type":16,"description":17,"interventionNames":18},"Eyelid Taping With Lubricant Eye Drops","EXPERIMENTAL","Patients receive preservative-free lubricant eye drops (carboxymethylcellulose 0.5%, single-dose vial) instilled into both conjunctival fornices immediately after anesthesia induction and loss of lid reflex, followed by hypoallergenic surgical tape applied horizontally across the tarsal plate of both eyes. Tape remains in place until extubation is complete.",[19],"Combination Product: Hypoallergenic Eyelid Taping With Lubricant Eye Drops",[21,29],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Hypoallergenic Eyelid Taping","Hypoallergenic surgical tape is applied horizontally across the tarsal plate of both eyes immediately after anesthesia induction and loss of lid reflex, prior to airway securing. The tape covers the entire lid margin without contacting the eyelashes. It remains in place until extubation is complete and spontaneous eye opening is confirmed.",[9],[27,28],"Eyelid Tape","Surgical Tape Eye Protection",{"type":30,"name":31,"description":32,"armGroupLabels":33,"otherNames":34},"COMBINATION_PRODUCT","Hypoallergenic Eyelid Taping With Lubricant Eye Drops","Preservative-free lubricant eye drops (carboxymethylcellulose 0.5%, single-dose vial) are instilled into both conjunctival fornices immediately after anesthesia induction and loss of lid reflex. Hypoallergenic surgical tape is then applied horizontally across the tarsal plate of both eyes. Tape remains in place until extubation is complete and spontaneous eye opening is confirmed.",[15],[35,36],"Tape Plus Artificial Tears","Eyelid Tape With Carboxymethylcellulose",[38],{"name":39,"affiliation":40,"role":41},"cansu ofluoglu, md","ISTANBUL PROVINCIAL HEALTH DIRECTORATE FATIH SULTAN MEHMET TRAINING AND RESEARCH HOSPITAL","PRINCIPAL_INVESTIGATOR",[43,48],{"name":39,"role":44,"phone":45,"phoneExt":46,"email":47},"CONTACT","+905358640564",null,"cansuakin.iu@gmail.com",{"name":49,"role":44,"phone":50,"phoneExt":46,"email":51},"doga meric yukselen, md","+905362963155","d.m.boybeyi@gmail.com",[53],{"facility":54,"status":46,"city":55,"state":46,"zip":56,"country":57,"countryCode":46,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Istanbul Provincial Health Directorate Fatih Sultan Mehmet Training and Research Hospital","Istanbul","34000","Turkey (Türkiye)",{"type":59,"coordinates":60},"Point",[61,62],28.94966,41.01384,{"lat":62,"lon":61},[65],{"name":39,"role":44,"phone":45,"phoneExt":46,"email":47},{"type":41,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":46,"oldOrganization":46},"Cansu Ofluoğlu","Specialist in Anesthesiology and Reanimation","100636200","eyelid-taping-alone-versus-taping-with-lubricant-eye-drops-for-perioperative-corneal-protection-100636200",false,"NCT07562594","Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection","Eyelid Taping Alone Versus Taping With Lubricant Eye Drops for Perioperative Corneal Protection During General Anesthesia: A Randomized Assessor-Blinded Trial With Cost-Effectiveness Analysis","Inclusion Criteria:\n\n* Age 18 to 75 years\n* ASA physical status I or II\n* Scheduled for elective non-ocular surgery under general anesthesia\n* Expected anesthesia duration between 30 and 180 minutes\n* Supine surgical position\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Preoperative corneal epithelial defect, keratitis, conjunctivitis, conjunctival hyperemia, or chemosis\n* Known ocular surface disease (dry eye syndrome, Sjögren syndrome, rheumatoid arthritis, systemic lupus erythematosus, or other systemic conditions associated with ocular surface involvement)\n* Use of topical or systemic medications known to affect tear production within the past 30 days\n* History of ocular surgery or ocular trauma\n* Contact lens use\n* Planned head and neck surgery\n* Prone or lateral decubitus surgical position\n* Patients requiring rapid sequence induction\n* Inability or refusal to provide written informed consent",true,"ALL","18 Years","75 Years",{"count":81,"type":82},200,"ESTIMATED","INTERVENTIONAL",[85],"NA","During general anesthesia, the eye's natural protective reflexes are suppressed, which can lead to corneal drying and injury. To prevent this, anesthesiologists routinely tape the eyelids closed. In many centers, lubricant eye drops are also applied in addition to taping, but whether this adds meaningful protection is unclear.This study will compare two approaches to eye protection during general anesthesia lasting 30 minutes to 3 hours: eyelid taping alone versus eyelid taping combined with lubricant eye drops. Two hundred adult patients undergoing elective, non-eye surgery in the supine position will be randomly assigned to one of the two groups.The main outcome is corneal surface damage measured by a standardized fluorescein staining score (NEI scale, 0-15) assessed by a blinded evaluator one hour after surgery. Secondary outcomes include tear film stability (TBUT), tear production (Schirmer test), patient-reported eye symptoms at 2 and 24 hours after surgery, and a cost-effectiveness analysis comparing the two approaches.If taping alone proves equally effective, routine use of lubricant eye drops may be unnecessary, reducing costs without compromising patient safety.",[88,89,90],"Corneal Injury","Exposure Keratopathy","Perioperative Complications",[92,93,94,95,96,97,98,99,100,101,102],"Corneal protection","General anesthesia","Eyelid taping","Lubricant eye drops","Corneal fluorescein staining","NEI corneal staining scale","Perioperative eye care","Schirmer test","Tear break-up time","Cost-effectiveness","Randomized controlled trial","NOT_YET_RECRUITING","2026-05-04",{"date":106,"type":107},"2026-05-07","ACTUAL",{"date":109,"type":82},"2026-06-01",{"date":111,"type":82},"2026-12-02",{"name":5,"class":6},1]