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GGT and\u002For alkaline phosphatase \\>1.5 times the normal values in two or more measurements taken at least 6 months apart,\n  2. A history of pruritus combined with \\[BA\\] \\>10 mmol\u002Fl for a period of ≥6 months.\n* Obtaining written informed consent\n\nExclusion Criteria:\n\n* Other documented causes of chronic liver disease that can justify the clinical phenotype include:\n\nPrimary biliary cholangitis Primary sclerosing cholangitis IgG4-related cholangiopathy Obstructive jaundice excluded by the demonstration of normal bile duct anatomy Negative virological tests for HBV, HCV, HEV Alcohol abuse Hemochromatosis Wilson's disease Alpha-1 antitrypsin deficiency","ALL","12 Months",{"count":86,"type":87},600,"ESTIMATED","OBSERVATIONAL","This is a cross-sectional, multicenter tissue study with an exploratory aim to estimate the prevalence of genetic mutations that predispose individuals to diseases in the context of cholestatic disorders and hepatobiliary neoplasms. It is intended as a hypothesis-generating study for future empirical investigations.",[91,92,93],"Hepatobiliary Cancers","Progressive Familial Intrahepatic Cholestasis (PFIC)","Cholestatic Liver Disease","2025-01-10",{"date":96,"type":97},"2025-01-16","ACTUAL",{"date":99,"type":97},"2024-10-22",{"date":101,"type":87},"2027-10",{"name":5,"class":6},5]