[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629208":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":62,"collaborators":25,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":25,"eligibilityCriteria":70,"healthyVolunteers":66,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":25,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Duke University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nurse Navigator-Delivered Family Building Decision Support","EXPERIMENTAL","Four \\~60-minute, weekly or biweekly videoconference sessions over 4-6 weeks. Components include:\n\n1. Personalized, risk-based reproductive health education based on cancer type and treatment exposures (e.g., gonadotoxic chemotherapy, chest or uterine radiation, anthracyclines); review of fertility potential evaluation, assisted reproductive technologies, adoption pathways, and pregnancy health considerations (maternal\u002Ffetal risks, surveillance, co-management).\n2. ACT-derived coping skills (values clarification, cognitive defusion, acceptance, committed action) to align decisions with personal values and reduce avoidance.\n3. Patient activation strategies to promote engagement in risk-based reproductive care and informed decision-making. Includes between-session practice and brief home exercises.",[13],"Behavioral: Nurse Navigator-Delivered Family Building Decision Support",{"label":15,"type":16,"description":17,"interventionNames":18},"Survivorship Educational Materials","ACTIVE_COMPARATOR","NCI booklet \"Facing Forward: Life After Cancer Treatment\" provided at baseline; participants may receive referrals to survivorship supportive services as needed.",[19],"Behavioral: Survivorship Education",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Four \\~60-minute, weekly or biweekly videoconference sessions over 4-6 weeks. Components include:\n\nPersonalized, risk-based reproductive health education based on cancer type and treatment exposures (e.g., gonadotoxic chemotherapy, chest or uterine radiation, anthracyclines); review of fertility potential evaluation, assisted reproductive technologies, adoption pathways, and pregnancy health considerations (maternal\u002Ffetal risks, surveillance, co-management).\n\nACT-derived coping skills (values clarification, cognitive defusion, acceptance, committed action) to align decisions with personal values and reduce avoidance.\n\nPatient activation strategies to promote engagement in risk-based reproductive care and informed decision-making.\n\nIncludes between-session practice and brief home exercises.",[9],null,{"type":22,"name":27,"description":17,"armGroupLabels":28,"otherNames":25},"Survivorship Education",[15],[30],{"name":31,"affiliation":5,"role":32},"Caroline S Dorfman, PhD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Smrithi Divakaran, MBBS, MSPH","CONTACT","919-681-7695","smrithi.divakaran@duke.edu",{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},"Michael W Willis, BA","919-681-8437","michael.w.willis@duke.edu",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Duke Cancer Institute","RECRUITING","Durham","North Carolina","27710","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-78.89862,35.99403,{"lat":56,"lon":55},[59,60,61],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},{"name":40,"role":36,"phone":41,"phoneExt":25,"email":42},{"name":31,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":63,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100629208","family-building-decision-support-for-female-adolescent-and-young-adult-cancer-survivors-100629208",false,"NCT07471685","Family Building Decision Support for Female Adolescent and Young Adult Cancer Survivors","Development and Pilot Testing of a Family Building Decision Support Intervention for Female Adolescent and Young Adult Cancer Survivors","Inclusion Criteria:\n\n* Female (biological sex) AYA cancer survivor age 15-39 at original diagnosis and 18-39 at enrollment.\n* Completed cancer treatment with curative intent.\n* Prior exposure to treatments posing gonadotoxic risk (e.g., alkylating agents, total body irradiation) and\u002For treatments increasing obstetric risk (e.g., chest radiation, radiation to uterus, anthracycline exposure).\n* Has not completed family building.\n* Able to speak\u002Fread English.\n* Willing and able to complete videoconference sessions and REDCap surveys.\n\nExclusion Criteria:\n\n* Visual, hearing, or cognitive impairment or severe mental illness that would interfere with participation as determined by study staff.","FEMALE","18 Years","39 Years",{"count":75,"type":76},48,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study aims to develop and pilot-test a nurse navigator-delivered behavioral program to support female adolescent and young adult (AYA) cancer survivors in making informed, values-driven family-building decisions after completion of cancer treatment. Female AYA survivors often face fertility impairments, uncertainty about reproductive potential, elevated obstetric risks during pregnancy, and significant emotional distress related to parenthood planning. Currently, few interventions address these post-treatment decision-making needs.\n\nThe intervention consists of four videoconference sessions that combine personalized, risk-based reproductive health education with coping strategies derived from Acceptance and Commitment Therapy and Patient Activation Theory. A pilot randomized controlled trial will evaluate feasibility, acceptability, and preliminary changes in knowledge, decisional conflict, self-efficacy, and reproductive-health-related distress among 48 participants randomized to the intervention or a survivorship-education control condition. Findings will inform future testing of the intervention's efficacy in a larger clinical trial.",[82,83,84],"Cancer Survivorship","Family Planning","Adolescent and Young Adult Cancer",[86,87,88,89],"AYA","oncofertility","fertility after cancer","survivorship","2026-05-12",{"date":92,"type":93},"2026-05-14","ACTUAL",{"date":95,"type":93},"2026-05-11",{"date":97,"type":76},"2026-12",{"name":5,"class":6},1]