[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615688":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":11,"centralContacts":27,"locations":36,"responsibleParty":126,"collaborators":11,"id":128,"slug":129,"hasResults":130,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":130,"sex":136,"minAge":137,"maxAge":11,"enrollmentInfo":138,"targetDuration":11,"studyType":141,"phases":142,"briefSummary":144,"conditions":145,"keywords":148,"overallStatus":157,"whyStopped":11,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":167},{"fullName":5,"class":6},"Mansoura University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"FANS-Based Flexible Ureteroscopy (FURS)","EXPERIMENTAL",null,[13],"Procedure: FANS-Based Flexible Ureteroscopy (FURS)",{"label":15,"type":16,"description":11,"interventionNames":17},"Suction-Assisted Mini-PCNL","ACTIVE_COMPARATOR",[18],"Procedure: Suction-Assisted Mini-PCNL",[20,24],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":11},"PROCEDURE","Under general\u002F spinal anesthesia, patients will be placed in lithotomy position. After guidewire placement, a flexible navigable suction ureteral access sheath (FANS) will be advanced to the renal pelvis. Lithotripsy will be performed using a digital flexible ureteroscope and holmium laser with optimized settings for dusting and fragmentation. Continuous irrigation combined with active suction will enhance visualization and fragment clearance. A double-J stent will be placed post-procedure.",[9],{"type":21,"name":15,"description":25,"armGroupLabels":26,"otherNames":11},"Under general or spinal anesthesia, patients will be placed in the prone position. Percutaneous renal access will be achieved under ultrasound or fluoroscopy guidance using an 18G puncture needle. Tract dilation will be performed up to 16-22 Fr, followed by the insertion of a suction-enabled miniaturized sheath (e.g., ClearPetra or equivalent). A mini-nephroscope will be introduced to visualize and fragment stones using Holmium:YAG fiber laser. Continuous irrigation combined with active negative-pressure suction through the access sheath will facilitate real-time removal of stone dust and fragments while maintaining low intrarenal pressure and clear visualization. A nephrostomy tube or double-J stent will be inserted at the surgeon's discretion.",[15],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":11,"email":32},"Mahmoud AN Laymon, A.Prof.","CONTACT","066053151","dr_mahmoudlaymon@mans.edu.eg",{"name":34,"role":30,"phone":11,"phoneExt":11,"email":35},"Ahmed Shokeir, Prof","ahmed.shokeir@hotmail.com",[37,53,64,72,80,88,96,107,118],{"facility":38,"status":11,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Urology and nephrology center","Al Mansurah","Outside U.S.\u002FCanada","35516","Egypt","EG",{"type":45,"coordinates":46},"Point",[47,48],31.38069,31.03637,{"lat":48,"lon":47},[51],{"name":52,"role":30,"phone":31,"phoneExt":11,"email":32},"Mahmoud AN Laymon",{"facility":54,"status":11,"city":55,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Alexandria University","Alexandria",{"type":45,"coordinates":57},[58,59],29.91582,31.20176,{"lat":59,"lon":58},[62],{"name":63,"role":30,"phone":11,"phoneExt":11,"email":11},"Amr Elgebaly",{"facility":65,"status":11,"city":66,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":67,"geoPoint":71,"contacts":11},"Assuit University","Asyut",{"type":45,"coordinates":68},[69,70],31.18368,27.18096,{"lat":70,"lon":69},{"facility":73,"status":11,"city":74,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":75,"geoPoint":79,"contacts":11},"Ain Shams University","Cairo",{"type":45,"coordinates":76},[77,78],31.24967,30.06263,{"lat":78,"lon":77},{"facility":81,"status":11,"city":74,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":82,"geoPoint":84,"contacts":85},"Cairo university",{"type":45,"coordinates":83},[77,78],{"lat":78,"lon":77},[86],{"name":87,"role":30,"phone":11,"phoneExt":11,"email":11},"Amr Elkady",{"facility":89,"status":11,"city":90,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":91,"geoPoint":95,"contacts":11},"Minya University","Minya",{"type":45,"coordinates":92},[93,94],30.75813,28.09193,{"lat":94,"lon":93},{"facility":97,"status":11,"city":98,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Menoufia University","Shibīn al Kawm",{"type":45,"coordinates":100},[101,102],31.00904,30.55258,{"lat":102,"lon":101},[105],{"name":106,"role":30,"phone":11,"phoneExt":11,"email":11},"Mohamed Elshazly",{"facility":108,"status":11,"city":109,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":110,"geoPoint":114,"contacts":115},"Tanta University","Tanta",{"type":45,"coordinates":111},[112,113],31.00192,30.78847,{"lat":113,"lon":112},[116],{"name":117,"role":30,"phone":11,"phoneExt":11,"email":11},"Maged Ragab",{"facility":119,"status":11,"city":120,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":121,"geoPoint":125,"contacts":11},"Zagazig university","Zagazig",{"type":45,"coordinates":122},[123,124],31.502,30.58768,{"lat":124,"lon":123},{"type":127,"investigatorFullName":11,"investigatorTitle":11,"investigatorAffiliation":11,"oldNameTitle":11,"oldOrganization":11},"SPONSOR","100615688","fans-furs-vs-suction-mini-pcnl-for-2-3-cm-renal-stones-a-multicenter-randomized-trial-100615688",false,"NCT07295860","FANS-FURS vs Suction Mini-PCNL for 2-3 cm Renal Stones: A Multicenter Randomized Trial","A Multicenter Randomized Trial Comparing FANS-Based Flexible Ureteroscopy Versus Suction Mini-Percutaneous Nephrolithotomy for Renal Stones 2-3 cm. The National Innovative Large Egyptian (NILE) Stone Study.","NILE","Inclusion Criteria:\n\n* Adults ≥18 years old.\n* Single or multiple renal stones measuring 2 -3 cm (diagnosed by NCCT).\n* Negative urine culture prior to surgery.\n* Suitable for general\u002Fspinal anesthesia.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Active urinary tract infection.\n* Anomalous renal anatomy (e.g., horseshoe kidney).\n* Severe ureteral strictures preventing retrograde access.\n* Coagulopathy or inability to discontinue anticoagulation.","ALL","18 Years",{"count":139,"type":140},254,"ESTIMATED","INTERVENTIONAL",[143],"NA","This multicenter, prospective, randomized clinical trial compares FANS-assisted flexible ureteroscopy (FURS) with suction-assisted mini-percutaneous nephrolithotomy (mini-PCNL) for the treatment of renal stones measuring 2-3 cm. A total of 280 patients will be enrolled across nine tertiary centers and randomized 1:1 to either technique. The primary endpoint is stone-free rate (SFR) at 1 month, assessed by non-contrast CT. Secondary outcomes include operative time, intraoperative complications, postoperative morbidity (Clavien-Dindo), pain scores, hospital stay, reinterventions, and quality of life (EQ-5D-5L). The study aims to provide the first high-quality head-to-head evidence comparing these two modern suction-enhanced technologies, with the goal of defining the optimal minimally invasive approach for medium-sized renal stones.",[146,147],"Stone, Kidney","Stone, Urinary",[149,150,151,152,153,154,155,156],"Renal stones","Nephrolithiasis","Urolithiasis","RIRS","FANS","mini-PCNL","Suction technology","Stone-free rate","NOT_YET_RECRUITING","2025-12-19",{"date":160,"type":161},"2025-12-26","ACTUAL",{"date":163,"type":140},"2026-01-01",{"date":165,"type":140},"2027-03-01",{"name":5,"class":6},9]