[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100631304":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":35,"locations":44,"responsibleParty":59,"collaborators":10,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":10,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":10,"studyType":75,"phases":10,"briefSummary":76,"conditions":77,"keywords":81,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Peking University People's Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"FAP-targeted PET in lung malignant tumors",null,"Participant who conforms to the inclusion criteria will undergo 68Ga-FAPI\u002FEB-FAPI PET\u002FCT scans within 1 week.",[13],"Diagnostic Test: PET\u002FCT scans",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DIAGNOSTIC_TEST","PET\u002FCT scans","PET Dynamic Data: The tracer is administered based on the patient's body weight at approximately 0.06-0.12 mCi\u002Fkg. PET scanning is initiated simultaneously with tracer injection, followed by a flush with 10 ml of normal saline. The image acquisition matrix is 192 × 192. Reconstruction is performed using the OSEM algorithm with 4 iterations and 20 subsets, incorporating time-of-flight attenuation correction, scatter correction, and random correction. The total duration of PET dynamic data acquisition is 60 minutes. Processing of PET dynamic scan data: Dynamic PET images are divided into 2-minute intervals to obtain time-activity curves by extracting the radioactivity within regions of interest at different time points, reflecting tracer uptake and enabling calculation of the time to peak. Multi-modality imaging data are analyzed by radiologists with over 10 years of experience in diagnosing respiratory diseases.",[9],[21,24,27,30,32],{"name":22,"affiliation":5,"role":23},"Kezhong Chen, MD","STUDY_DIRECTOR",{"name":25,"affiliation":5,"role":26},"Jun Wang, M.M.","STUDY_CHAIR",{"name":28,"affiliation":5,"role":29},"Hao Li, MD","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":5,"role":29},"Yuan Li, MD",{"name":33,"affiliation":34,"role":29},"Zhaohui Zhu, MD","Peking Union Medical College Hospital",[36,40],{"name":22,"role":37,"phone":38,"phoneExt":10,"email":39},"CONTACT","+86-010-88325983","mdkzchen@163.com",{"name":41,"role":37,"phone":10,"phoneExt":42,"email":43},"Qingyun Liu, MD","+8615165620919","qingyun_liu919@163.com",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":10,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Beijing","Beijing Municipality","China","CN",{"type":52,"coordinates":53},"Point",[54,55],116.39723,39.9075,{"lat":55,"lon":54},[58],{"name":22,"role":37,"phone":38,"phoneExt":10,"email":39},{"type":29,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Chen KeZhong","Director of Thoracic Oncology Institute","100631304","fap-targeted-petnir-in-lung-malignant-tumors-100631304",false,"NCT07498933","FAP-targeted PET\u002FNIR in Lung Malignant Tumors","Visualization Study on Tumor Progression Mechanisms and Key Molecular Functions in Neoadjuvant Immunotherapy for Lung Cancer: Preoperative Efficacy Prediction and Intraoperative Fluorescence Navigation","Inclusion Criteria:\n\n* Age between 18 and 70 years old;\n* Have complete clinical and imaging data;\n* Prior to neoadjuvant therapy, the biopsy pathology showed lung cancer;\n* Able to retain sufficient tumor tissue for testing and research;\n* Sign informed consent.\n\nExclusion Criteria:\n\n* Previously combined with other malignant tumors or received other anti-tumor treatments;\n* Failure to collect sufficient tumor tissue for testing and research;\n* The duration of neoadjuvant therapy is less than 3 cycles;\n* The dynamic scanning image quality of multimodal probe PET cannot meet the analysis standards or is missing;\n* Lack of clinical and imaging data;\n* There are situations where other researchers consider it inappropriate to participate in this study","ALL","18 Years","70 Years",{"count":73,"type":74},200,"ESTIMATED","OBSERVATIONAL","Single center, prospective, diagnostic study. Patients with stage II-IIIB resectable NSCLC diagnosed by pathology were included. After receiving standard neoadjuvant therapy (chemotherapy\u002Fimmunotherapy\u002Fcombination therapy), FAPI-PET\u002FCT and fluorescence imaging were performed one week before surgery. During the surgery, a near-infrared fluorescence navigation system was used to locate the tumor lesion. After surgery, the tumor bed range was determined by pathological gold standards (HE staining+immunohistochemistry), and the predictive efficacy and localization accuracy of FAPI-PET\u002Ffluorescence were compared and analyzed.",[78,79,80],"Non-Small Cell Lung Cancer","PET\u002FCT","Neoadjuvant Therapy",[82,83,80,78],"PET Imaging","NIR Imaging","2026-03-26",{"date":86,"type":87},"2026-04-01","ACTUAL",{"date":89,"type":87},"2025-06-03",{"date":91,"type":74},"2027-12-31",{"name":5,"class":6},1]