[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100620594":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":31,"centralContacts":35,"locations":44,"responsibleParty":99,"collaborators":103,"id":110,"slug":111,"hasResults":112,"nctId":113,"briefTitle":114,"officialTitle":115,"acronym":116,"eligibilityCriteria":117,"healthyVolunteers":112,"sex":118,"minAge":119,"maxAge":10,"enrollmentInfo":120,"targetDuration":10,"studyType":123,"phases":10,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":143},{"fullName":5,"class":6},"University of Cagliari","OTHER",[8,14,18,22],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with Necrotizing Soft Tissue Infections.",null,"Adult patients admitted with a diagnosis of necrotizing soft tissue infection, diagnosed based on clinical findings, imaging when available, and\u002For intraoperative assessment.",[13],"Other: No Intervention: Observational Cohort",{"label":15,"type":10,"description":16,"interventionNames":17},"Necrotizing Fasciitis","Patients with necrotizing infection primarily involving the fascia and surrounding soft tissues, diagnosed based on clinical findings, imaging when available, and\u002For intraoperative assessment.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Fournier's Gangrene","Patients with necrotizing infection involving the perineal, genital, or perianal region, consistent with Fournier's gangrene.",[13],{"label":23,"type":10,"description":24,"interventionNames":25},"Necrotizing Soft Tissue Infections of the Neck and Trunk","Patients with necrotizing soft tissue infections involving the cervical region or the trunk, including thoracic and abdominal wall locations.",[13],[27],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":10},"No Intervention: Observational Cohort","No experimental intervention, treatment assignment, or change in clinical management is performed as part of the study.\n\nAll patients receive standard medical and surgical care according to local institutional protocols and current clinical practice guidelines. Diagnostic and therapeutic decisions are made solely by the treating clinical teams and are not influenced by participation in the study.",[19,15,23,9],[32],{"name":33,"affiliation":5,"role":34},"Adolfo Pisanu, MD","STUDY_DIRECTOR",[36,41],{"name":37,"role":38,"phone":39,"phoneExt":10,"email":40},"Mauro Podda, MD, FACS, Professor of Surgery","CONTACT","+39 07051096571","mauro.podda@unica.it",{"name":42,"role":38,"phone":39,"phoneExt":10,"email":43},"Valentina Murzi, MD","valentina.murzi@unica.it",[45,60,73,86],{"facility":46,"status":47,"city":48,"state":10,"zip":10,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Cagliari University Hospital \"Duilio Casula\".","RECRUITING","Cagliari","Italy","IT",{"type":52,"coordinates":53},"Point",[54,55],9.11917,39.23054,{"lat":55,"lon":54},[58],{"name":59,"role":38,"phone":39,"phoneExt":10,"email":40},"Mauro Podda, MD",{"facility":61,"status":47,"city":62,"state":10,"zip":10,"country":49,"countryCode":50,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Niguarda Hospital, Trauma team.","Milan",{"type":52,"coordinates":64},[65,66],12.59836,42.78235,{"lat":66,"lon":65},[69],{"name":70,"role":38,"phone":71,"phoneExt":10,"email":72},"Tiziana Pilia, MD","+ 39 02 6444 3030","tiziana.pilia@libero.it",{"facility":74,"status":47,"city":75,"state":10,"zip":10,"country":49,"countryCode":50,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"San Gerardo Hospital, Department of Surgery","Monza",{"type":52,"coordinates":77},[78,79],9.27246,45.58005,{"lat":79,"lon":78},[82],{"name":83,"role":38,"phone":84,"phoneExt":10,"email":85},"Marco Ceresoli, MD","+ 39 039 233 3651","ceresoli@unimib.it",{"facility":87,"status":47,"city":88,"state":10,"zip":10,"country":49,"countryCode":50,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Gemelli Hospital, Rome. Department of Surgery.","Roma",{"type":52,"coordinates":90},[91,92],11.10642,44.99364,{"lat":92,"lon":91},[95],{"name":96,"role":38,"phone":97,"phoneExt":10,"email":98},"Fausto Rosa, MD","+39 0688818881","faustofrosa@unicatt.it",{"type":100,"investigatorFullName":101,"investigatorTitle":102,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Mauro Podda","Professor",[104,106,108],{"name":105,"class":6},"University of Milano Bicocca",{"name":107,"class":6},"University of Milan",{"name":109,"class":6},"Catholic University of the Sacred Heart","100620594","fatal-nsti-study-factors-associated-with-in-hospital-mortality-in-nsti-100620594",false,"NCT07359651","FATAL-NSTI Study (Factors Associated With In-hospital mortALity in NSTI).","Factors Associated With In-hospital Mortality in Necrotizing Soft Tissue Infections. A Multicenter Retrospective Cohort Study. FATAL-NSTI Study (Factors Associated With In-hospital mortALity in NSTI).","FATAL-NSTI","Inclusion Criteria:\n\n* Age 18 years or older\n* Hospital admission with a diagnosis of necrotizing soft tissue infection, including: Necrotizing fasciitis, Fournier's gangrene, Necrotizing soft tissue infections involving the neck or trunk.\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Patients with non-necrotizing skin or soft tissue infections\n* Patients transferred to another hospital before completion of treatment or outcome assessment\n* Missing data for the primary outcome (in-hospital mortality)","ALL","18 Years",{"count":121,"type":122},300,"ESTIMATED","OBSERVATIONAL","Necrotizing soft tissue infections (NSTIs) are rare but potentially life-threatening infections involving the skin and underlying tissues such as fat, fascia, and sometimes muscle. They can progress rapidly and, despite modern antibiotics, surgery, and intensive care, are still associated with high in-hospital mortality.\n\nA major challenge in the management of NSTIs is early diagnosis. Initial signs and symptoms are often nonspecific and may resemble less severe soft tissue infections, leading to diagnostic and therapeutic delays. Once identified, treatment requires urgent surgery, broad-spectrum antibiotics, and close monitoring, frequently in an intensive care setting.\n\nEven with appropriate treatment, the clinical course of NSTIs is highly variable. Some patients recover, while others develop severe complications such as septic shock or multiple organ failure and may die during hospitalization. Predicting outcomes early in the hospital stay remains difficult for clinicians.\n\nThe aim of this observational study is to identify factors associated with in-hospital mortality in adult patients with NSTIs. In-hospital mortality, defined as death from any cause during the hospital stay for NSTI treatment, represents the most severe outcome and is of major relevance to patients and caregivers.\n\nThe study focuses on clinical and laboratory data routinely available at hospital admission or during initial emergency department evaluation. These include patient demographics, vital signs, and standard blood test results commonly obtained in early clinical assessment. No additional diagnostic tests or procedures are required for study purposes.\n\nIdentifying early predictors of mortality is particularly important in NSTIs, given the rapid progression of the disease. Early recognition of high-risk patients may allow closer monitoring and more timely interventions.\n\nThe study will be conducted in high-volume referral centers with extensive experience in NSTIs management, where care is delivered according to established international guidelines. All patients will receive standard treatment based on clinical judgment. No experimental therapies or changes in routine care will be involved.",[126,127,19,128],"Necrotizing Fascitis","Fournier Gangrene","Soft Tissue Infections",[130,131,132,133],"Necrotizing soft tissues infections","NSTI","Necrotizing fasciitis","Fournier's gangrene","2026-01-15",{"date":136,"type":137},"2026-01-22","ACTUAL",{"date":139,"type":137},"2020-01-01",{"date":141,"type":122},"2026-04-30",{"name":5,"class":6},4]