[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558620":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":38,"centralContacts":43,"locations":49,"responsibleParty":63,"collaborators":30,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":30,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":30,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":30,"overallStatus":88,"whyStopped":30,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Universidad Autonoma de Baja California","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"FatMax group","EXPERIMENTAL","low-intensity exercise training sessions (FatMax zone)",[13],"Other: FatMAx training intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"FatMAx and musuclar endurance exercise group","FatMax zone exercises as well as muscular resistance exercises",[18],"Other: FatMax and physical endurance exercise intervention",{"label":20,"type":21,"description":22,"interventionNames":23},"Control","ACTIVE_COMPARATOR","Group without physical activity intervention",[24],"Other: Control",[26,31,35],{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"FatMAx training intervention","FatMax training program on a treadmill or stationary bicycle, whichever is more convenient for them",[9],null,{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"FatMax and physical endurance exercise intervention","FatMax training program on a treadmill or stationary bicycle, whichever is more convenient for them, with muscular endurance exercise",[15],{"type":6,"name":20,"description":36,"armGroupLabels":37,"otherNames":30},"No intervention pf physical activity",[20],[39],{"name":40,"affiliation":41,"role":42},"René Bassó-Quevedo, MSc","Bioethic Comittee of the Autonomous University of Baja California","STUDY_CHAIR",[44],{"name":45,"role":46,"phone":47,"phoneExt":30,"email":48},"María G. Delgadillo-Ramos, Dr.","CONTACT","6646797576","lupitadelgadillo@uabc.edu.mx",[50],{"facility":51,"status":30,"city":52,"state":53,"zip":54,"country":55,"countryCode":56,"cosmosGeoPoint":57,"geoPoint":62,"contacts":30},"Medical and Psychology School","Tijuana","California","22390","Mexico","MX",{"type":58,"coordinates":59},"Point",[60,61],-117.00371,32.5027,{"lat":61,"lon":60},{"type":64,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"PRINCIPAL_INVESTIGATOR","Marco Antonio Hernández Lepe","Principal Investigator","100558620","fatmax-training-on-metabolic-and-epigenetic-parameters-100558620",false,"NCT06553482","FatMax Training on Metabolic and Epigenetic Parameters","Impact of Exercise Training at Maximal Fat Oxidation (FatMax) Intensity on Metabolic and Epigenetic Parameters in Subjects With Excessive Body Mass: Study Protocol of a Randomized Controlled Trial","Inclusion Criteria:\n\n* Both genders\n* Daily energy expenditure \\\u003C4 METs\n* Body mass index ≥25 kg\u002Fm2\n* Acceptance of informed consent\n\nExclusion\u002Felimination Criteria:\n\n* ≥100 ml of alcohol consumption per week\n* Consume a dietary supplement or pharmacological treatment\n* Have limitations to perform regular physical activity\n* Have a chronic non-communicable disease\n* Answer \"yes\" to any of the questions on the Physical Activity Readiness- Questionnaire for Everyone (PAR-Q+); which represents a health risk.\n* \\\u003C80% attendance at exercise sessions",true,"ALL","18 Years","35 Years",{"count":79,"type":80},156,"ESTIMATED","INTERVENTIONAL",[83],"NA","Exercise is an essential pillar for the health of all individuals, as it contributes to physical, mental, and emotional well-being. Various international organizations, such as the World Health Organization, advocate for the integration of exercise into healthy lifestyles, recognizing its im-portance in disease prevention and improving quality of life. However, despite the general consensus on its value, there is no universal agreement on specific prescriptions for vulnerable groups, highlighting the need for personalized approaches that consider the unique characteristics and needs of each individual. It has been proposed that a moderate aerobic exercise training program could promote positive outcomes in individuals living with overweight and obesity, particularly with an emphasis on reducing injury risk, ensuring high adherence, and achieving favorable health changes. In this regard, the present protocol establishes the basis for a randomized clinical trial based on exercise prescription at the maximal fat oxidation rate in young individuals with overweight and obesity, with a duration of 16 weeks. Throughout the study, biochemical changes (cholesterol, glucose, triglycerides, and inflammatory markers), metabolic changes (de-termination of fat and carbohydrate utilization rates during rest and exercise), and epigenetic changes (focusing on microRNAs associated with adipogenesis, inflammation, and fat metabolism) will be monitored.",[86,87],"Overweight and Obesity","Body Weight Changes","NOT_YET_RECRUITING","2024-08-13",{"date":91,"type":92},"2024-08-15","ACTUAL",{"date":94,"type":80},"2025-01-01",{"date":96,"type":80},"2027-01-01",{"name":5,"class":6},1]