[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624989":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":31,"responsibleParty":51,"collaborators":19,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":19,"eligibilityCriteria":58,"healthyVolunteers":55,"sex":59,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":19,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":73,"overallStatus":34,"whyStopped":19,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"The University of Texas Medical Branch, Galveston","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise Program","EXPERIMENTAL","Participants will complete a 12-week progressive exercise program with 50-minute sessions three times per week, including warm-up, resistance training, and cool-down. Supervision transitions from primarily in-person (Weeks 1-2) to mixed (Weeks 5-8) and mostly unsupervised with virtual support (Weeks 9-12). Weekly check-ins are provided, and a final assessment occurs at Week 13.",[13],"Other: Progressive Exercise Program (12 Weeks)",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Progressive Exercise Program (12 Weeks)","12-week exercise program with gradual transition from supervised to independent sessions. Participants complete 50-minute sessions, 3 times\u002Fweek, including:\n\nWarm-up (10 min) Resistance training (35 min): upper arm exercises, wall push-ups, biceps curls, side bends, squats, glute bridges, hip abduction Cool-down (5 min)\n\nSupervision:\n\nWeeks 1-2: Mostly supervised Weeks 5-8: Mixed Weeks 9-12: Mostly unsupervised with Zoom\u002FTeams support\n\nWeekly staff check-ins. Week 13: Repeat baseline tests, questionnaires, blood draw, DEXA scan, and structured interview.",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Mandeep Sandhu, PhD, PT","University of Texas Medial Branch","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Liza Durgens","CONTACT","(409)772-1011","lidurgen@utmb.edu",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of Texas Medical Branch, Galveston","RECRUITING","Galveston","Texas","77555-0133","United States","US",{"type":41,"coordinates":42},"Point",[43,44],-94.7977,29.30135,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":49,"phoneExt":19,"email":50},"Mandeep Sandhu, PhD,PT","409-772-1011","masandhu@utmb.edu",{"type":52,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR","100624989","feasibility-and-adherence-to-a-technology-assisted-home-based-strength-training-program-in-adults-with-type-2-diabetes-mellitus-and-mild-cognitive-impairment-100624989",false,"NCT07416799","Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment","Inclusion Criteria:\n\n1. Age: 55-80 years\n2. Diabetes: Diagnosed T2DM with ≥5 years duration\n3. Cognitive Status: Mild cognitive impairment as defined by Petersen criteria and confirmed by Montreal Cognitive Assessment (MoCA) scores of 18-25\n4. Medication Stability: Stable medication regimen for at least 3 months\n5. Physical Capability: Physically capable of participating in moderate-intensity exercise (physician clearance required)\n6. Support System: Having a caregiver or support person willing to assist with technology use if needed\n\nExclusion Criteria:\n\n1. Diagnosis of movement disorders such as multiple sclerosis, parkinson's disease\n2. Diagnosis of Alzheimer's disease,\n3. Current diagnosis of severe depression, major psychiatric conditions such as bipolar disorder, psychosis, schizophrenia, or alcoholism that could affect the ability to understand and\u002For cooperate fully with the protocol.\n4. Significant cerebral vascular disease\n5. Concomitant medications with significant cholinergic or anticholinergic effects or adverse effects on cognition, including antipsychotics, tricyclic antidepressants, anticonvulsants, sedative\u002Fhypnotics, anxiolytics, glucocorticoids (chronic or frequent intermittent),\n6. Visual\u002Fhearing impairment that would significantly impact the ability to participate in psychometric testing.\n7. Significant medical illness or organ failure, including hepatic or renal failure, unstable cardiac disease,\n8. Untreated B12 deficiency or hypothyroidism (stable treatment for at least 3 months is allowable).\n9. Uncontrolled hypertension: over 160 mmHg systolic or 100 mmHg diastolic (stable treatment is allowable).\n10. Stage 5 renal impairment (GFR less than 15 or dialysis).\n11. Participation in another clinical trial.\n12. Prisoners.\n13. Exercise Contraindications: Any condition that would make moderate-intensity exercise unsafe such as a history of severe aortic stenosis, poorly controlled hypertension, angina, or syncope.\n14. Lack of Support: No available caregiver or support person for technology assistance","ALL","55 Years","80 Years",{"count":63,"type":64},20,"ESTIMATED","INTERVENTIONAL",[67],"NA","This is a single-arm feasibility study employing a pre-post design with a 12-week intervention period. The study utilizes a telehealth-assisted home-based resistance exercise program, with a structured progression from supervised to unsupervised sessions over 12 weeks.",[70,71,72],"Type2diabetes","Mild Cognitive Impairment","Age-related Cognitive Decline",[74,75,76,77],"Home-Based exercise","Type 2 Diabetes Mellitus (T2DM)","Mild cognitive impairment (MCI)","Ages 55-80","2026-05-07",{"date":80,"type":81},"2026-05-11","ACTUAL",{"date":83,"type":81},"2026-04-14",{"date":85,"type":64},"2027-03",{"name":5,"class":6},1]