[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100446933":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":29,"responsibleParty":47,"collaborators":19,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":19,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":19,"overallStatus":32,"whyStopped":19,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Children's National Research Institute","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"EndeavorRx","EXPERIMENTAL","Children will be asked to begin attentional control training at home within two weeks of baseline testing and to complete 6 training missions per day (25-30 minutes), 5 days per week, for 4 weeks (total = 120 training missions).",[13],"Device: EndeavorRx",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","EndeavorRx is a digital intervention delivered through an action video game that is indicated to improve attention function. EndeavorRx users first complete two discrete tasks: 1) a perceptual discrimination\u002Fattention task in which users respond to target stimuli and ignore distractor stimuli (e.g., tapping the screen quickly only when red aliens appear) and 2) a sensorimotor navigation task in which users tilt their device to steer a hovercraft down a river while targeting or avoiding certain objects. Users are subsequently presented with a multitask training session where they complete the perceptual discrimination\u002Fattention task and the sensorimotor navigation task simultaneously. Algorithms adapt the program in both real-time and between sessions to automatically adjust the difficulty level.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Steven J Hardy, Ph.D.","PRINCIPAL_INVESTIGATOR",[25],{"name":22,"role":26,"phone":27,"phoneExt":19,"email":28},"CONTACT","202-476-5000","sjhardy@childrensnational.org",[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Children's National Hospital","RECRUITING","Washington D.C.","District of Columbia","20010","United States","US",{"type":39,"coordinates":40},"Point",[41,42],-77.03637,38.89511,{"lat":42,"lon":41},[45],{"name":46,"role":26,"phone":27,"phoneExt":19,"email":28},"Steven Hardy, PhD",{"type":23,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Steven J. Hardy","Associate Professor of Psychiatry and Behavioral Sciences","100446933","feasibility-and-efficacy-of-attentional-control-training-in-sickle-cell-disease-100446933",false,"NCT05099874","Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease","ACT","Inclusion Criteria:\n\n* diagnosis of SCD\n* ages 8-16 years\n* maintained on monthly blood transfusions consistently for at least 3 months.\n* patients will be proceed to the intervention phase only if they have a T-score \\> 75th percentile for Omission Errors on the Conners' Continuous Performance Test, 3rd Edition (CPT-3) or a T-score \\> 75th percentile for the Inattention subscale of the ADHD Rating Scale, Fifth Edition (ADHD-RS-V).\n\nExclusion Criteria:\n\n* estimated Intelligence Quotient \\\u003C 70\n* motor, visual, or auditory impairment that prevents computer use\n* known diagnosis of a mental health condition that precludes, or takes treatment precedence over, participation in cognitive training\n* history of photosensitive seizures\n* insufficient English fluency.","ALL","8 Years","16 Years",{"count":61,"type":62},20,"ESTIMATED","INTERVENTIONAL",[65],"NA","Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD. EndeavorRx (Akili Interactive Labs: Boston, MA) is an FDA-approved home-based, electronic attentional-control training program designed to treat attention problems in youth. Users access EndeavorRx on a tablet device for 25-30 minutes each day, 5 days per week, for 4 weeks. The program involves training in a game-like environment that repeatedly challenges attentional-control abilities and adapts to user performance, becoming more difficult over time as performance improves. This pilot study is examining the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a sample of 20 children with SCD ages 8-16 who are being treated with chronic blood transfusion therapy.",[68,69,70],"Sickle Cell Disease","Attention Deficit","Cognitive Deficit in Attention","2025-01-08",{"date":73,"type":74},"2025-01-10","ACTUAL",{"date":76,"type":74},"2022-12-20",{"date":78,"type":62},"2025-12",{"name":5,"class":6},1]