[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627192":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":25,"locations":31,"responsibleParty":49,"collaborators":19,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":54,"sex":59,"minAge":60,"maxAge":19,"enrollmentInfo":61,"targetDuration":19,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":19,"overallStatus":34,"whyStopped":19,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Azienda Ospedaliero-Universitaria di Parma","OTHER",[8],{"label":9,"type":6,"description":10,"interventionNames":11},"Hematological malignancies","Patients with clinical suspect of hematological malignancies or Relapsed and Refractory (R\u002FR) onco-hematological disorders",[12,13],"Other: Multi-omics analyses","Biological: Functional tests",[15,20],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Multi-omics analyses","The focus of our scientific approach is based on multi-omics analyses: NGS (Next Generation Sequencing analysis), Bulk Transcriptomics, Single-cell resolution, Single-cell transcriptomics and phosphoproteomics.",[9],null,{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":19},"BIOLOGICAL","Functional tests","Functional analyses will be performed on primary sample from each enrolled patient. Malignant cells are cultered and incubated with a specific library of drugs (300 drugs) at four different concentrations for 72 hours.",[9],[26],{"name":27,"role":28,"phone":29,"phoneExt":19,"email":30},"Giovanni Roti, Associate Professor","CONTACT","+39 0521 702200","giovanni.roti@unipr.it",[32],{"facility":33,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"University of Parma","RECRUITING","Parma","PR","43126","Italy","IT",{"type":41,"coordinates":42},"Point",[43,44],10.32618,44.79935,{"lat":44,"lon":43},[47],{"name":48,"role":28,"phone":29,"phoneExt":19,"email":30},"Giovanni Roti",{"type":50,"investigatorFullName":48,"investigatorTitle":51,"investigatorAffiliation":33,"oldNameTitle":19,"oldOrganization":19},"PRINCIPAL_INVESTIGATOR","Professore associato","100627192","feasibility-of-a-multi-omics-platform-for-hematological-malignancies-100627192",false,"NCT07445438","Feasibility of a Multi-omics Platform for Hematological Malignancies","FOCUS","Inclusion Criteria:\n\n* Patient aged \\> 2 year old\n* Retrospective study:\n* Patients previously diagnosed with hematological malignancies\n* Prospective study:\n* Patients with clinical suspect of hematological malignancies requiring a diagnostic assessment using BM or PB samples, biopsies of lymph nodes or tissues with metastatic involvement, or other biological fluids (such as CSF, pathologic pleural effusion).\n* Patients with clinical suspicion of R\u002FR onco-hematological disorder, requiring a diagnostic assessment using BM aspirate\u002Fbiopsy or biopsies of tissues with metastatic involvement including lymph nodes, liquor from lumbar puncture, tissue aspirate etc.\n* Patients with blastic transformation from a chronic condition or suspect of R\u002FR hematological disease requiring a diagnostic assessment using PB drawn, BM aspirate\u002Fbiopsy, lymph nodes biopsies, or biopsies of tissues with metastatic involvement, including CSF from lumbar puncture, tissue aspirate, etc.\n\nExclusion Criteria:\n\n* Age \\\u003C2 year old\n* Patient without a diagnosis of hematological malignancy.","ALL","2 Years",{"count":62,"type":63},1040,"ESTIMATED","INTERVENTIONAL",[66],"NA","This is a biological study based on a collaborative effort involving several Italian haematology centres (including the coordinating centre). The study will be conducted retrospectively and prospectively using bone marrow (BM) or peripheral blood (PB) samples, lymph node or tissue biopsies with metastatic involvement, and other biological fluids, such as cerebrospinal fluid and pathological pleural effusion.",[69,70,71,72,73,74],"Myeloma Multiple","Chronic Leukemia","Acute Leukemia","Myeloproliferative Disorders","Lymphoproliferative Disorders","Myelodysplastic Disorders","2026-02-25",{"date":77,"type":78},"2026-03-03","ACTUAL",{"date":80,"type":78},"2025-03-31",{"date":82,"type":63},"2030-03",{"name":5,"class":6},1]