[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100581962":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":59,"collaborators":62,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":67,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":25,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":41,"whyStopped":25,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"University of Pittsburgh","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Exercise With Rest","EXPERIMENTAL","Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include two 45 minute rest periods between exercises and take about two and a half hours.",[13],"Behavioral: Exercise with Rest",{"label":15,"type":16,"description":17,"interventionNames":18},"Exercise Without Rest","ACTIVE_COMPARATOR","Exercise without Rest",[19],"Behavioral: Exercise without Rest",[21,26],{"type":22,"name":23,"description":11,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Exercise with Rest",[9],null,{"type":22,"name":17,"description":27,"armGroupLabels":28,"otherNames":25},"Participants in this arm exercise 3 times a week for 12 weeks. Exercise program consists of warm-up, strengthening exercises of the lower major extremity muscle groups, and aerobic training using a treadmill. These sessions include minimal resting periods between exercises and take about one hour.",[15],[30],{"name":31,"affiliation":5,"role":32},"Sara Piva","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Gaupp","CONTACT","412-383-0742","awg26@pitt.edu",[40],{"facility":5,"status":41,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"RECRUITING","Pittsburgh","Pennsylvania","15213","United States","US",{"type":48,"coordinates":49},"Point",[50,51],-79.99589,40.44062,{"lat":51,"lon":50},[54,58],{"name":55,"role":36,"phone":56,"phoneExt":25,"email":57},"Sara R Piva, PhD, PT, FAPTA","412-383-6712","spiva@pitt.edu",{"name":55,"role":32,"phone":25,"phoneExt":25,"email":25},{"type":32,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Sara R. Piva","Professor and Vice Chair for Research",[63],{"name":64,"class":6},"Carnegie Mellon University","100581962","feasibility-of-resting-intervals-during-exercise-programs-for-individuals-with-knee-osteoarthritis-100581962",false,"NCT06857123","Feasibility of Resting Intervals During Exercise Programs for Individuals With Knee Osteoarthritis","Mechanical and Molecular Determinants of Cartilage Response to Exercise","CaRE","Inclusion Criteria:\n\n* Age between 45 and 79 yo.\n* Clinical diagnosis of primary, early to moderate stage knee osteoarthritis.\n* BMI range \\\u003C 35 kg\u002Fm2.\n* Sedentary lifestyle\n* Knee joint is the most painful joint in the body.\n* Ability to speak and understand English.\n* Willingness to comply with all study procedures and be available for the duration of the study.\n\nExclusion Criteria:\n\n* Non-OA disease of the knee.\n* Advanced knee osteoarthritis\n* Knee injection in the past 3 months.\n* Major knee trauma\u002Fsurgery in the past 5 years or previous knee surgery with hardware limiting cartilage assessment..\n* Participate in regular exercise or physical activity .\n* Participation in an intervention study for knee OA.\n* Currently using a cane, walker or crutches to walk.\n* History of cardiovascular disease or hypertension not controlled by medication.\n* Two or more unexplained falls in the past year.\n* Inflammatory, autoimmune disorders, neurological, systemic, muscular, or connective tissue conditions that affect walking or ability to exercise.\n* Contraindication to MRI.\n* Medical condition or characteristic of the participant that could place the individual at increased risk or preclude s\u002Fhe from complying with study procedures.\n* Pregnant female.\n* Acute or terminal illness.","ALL","45 Years","79 Years",{"count":77,"type":78},20,"ESTIMATED","INTERVENTIONAL",[81],"NA","This pilot randomize trial tests the feasibility of administering two different exercise programs in people with knee osteoarthritis. One group receives the exercise program administered as usual, and the other group received the exercise program with resting intervals.",[84],"Knee Osteoarthristis",[86,87,88,89],"Knee","Osteoarthritis","exercise","feasibility","2026-02-04",{"date":92,"type":93},"2026-02-09","ACTUAL",{"date":95,"type":93},"2024-12-04",{"date":97,"type":78},"2026-12-31",{"name":5,"class":6},1]