[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100479896":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":39,"responsibleParty":57,"collaborators":60,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":72,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":25,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":25,"overallStatus":42,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Children's National Research Institute","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"EndeavorRx","EXPERIMENTAL","Children will be asked to begin digital attentional control training at home within 6 weeks of baseline testing and to complete 6 training missions per day (25-30 minutes), 5 days per week, for 4 weeks (total = 120 training missions).",[13],"Device: EndeavorRx",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","ACTIVE_COMPARATOR","An active control program designed to replicate aspects of the intervention (e.g., regular use of digital device to access fun educational activities) while engaging cognitive skills not particularly involving attention.",[19],"Other: Control video game",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","EndeavorRx is a digital intervention delivered through an action video game that is indicated to improve attention function. EndeavorRx users first complete two discrete tasks: 1) a perceptual discrimination\u002Fattention task in which users respond to target stimuli and ignore distractor stimuli (e.g., tapping the screen quickly only when red aliens appear) and 2) a sensorimotor navigation task in which users tilt their device to steer a hovercraft down a river while targeting or avoiding certain objects. Users are subsequently presented with a multitask training session where they complete the perceptual discrimination\u002Fattention task and the sensorimotor navigation task simultaneously. Algorithms adapt the program in both real-time and between sessions to automatically adjust the difficulty level.",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Control video game","The active control program, used in previous studies of this intervention, was designed to match EndeavorRx on expectancy, engagement, and time on task in the form of a challenging and engaging digital word game, targeting cognitive domains not targeted by EndeavorRx and not primarily associated with attentional difficulties. Users are instructed to find and connect letters on a grid to spell words; points are awarded based on number of words formed, word length, and the use of unusual letters. There is progression in difficulty to maintain engagement and expectation of benefit from patients and their caregivers.",[15],[31],{"name":32,"affiliation":5,"role":33},"Steven Hardy, Ph.D.","PRINCIPAL_INVESTIGATOR",[35],{"name":32,"role":36,"phone":37,"phoneExt":25,"email":38},"CONTACT","202-476-5000","sjhardy@childrensnational.org",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Children's National Hospital","RECRUITING","Washington D.C.","District of Columbia","20010","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-77.03637,38.89511,{"lat":52,"lon":51},[55],{"name":56,"role":36,"phone":37,"phoneExt":25,"email":38},"Steven Hardy, PhD",{"type":33,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Steven J. Hardy","Principal Investigator",[61,63,65,67],{"name":62,"class":6},"St. Jude Children's Research Hospital",{"name":64,"class":6},"Children's Hospital of Philadelphia",{"name":66,"class":6},"George Washington University",{"name":68,"class":69},"National Cancer Institute (NCI)","NIH","100479896","feasibilityacceptability-of-attentional-control-training-in-survivors-100479896",false,"NCT05528939","Feasibility\u002FAcceptability of Attentional-Control Training in Survivors","FAACTS: Feasibility\u002FAcceptability of Attentional-Control Training in Survivors","FAACTS","Inclusion Criteria:\n\n* Aged 8-16 years at time of screening.\n* History of diagnosis of acute lymphoblastic leukemia (ALL) or brain tumor (BT).\n* At least 1 year from completion of planned therapy and stable from a disease standpoint.\n* Participating child and caregiver are fluent in spoken English.\n* Availability of a caregiver who is willing and capable of providing support and supervision during cognitive training.\n* Participating child is either not taking any prescribed stimulant medication for attention difficulties or has been prescribed a stable dose of stimulant medication for attention difficulties for at least 30 days prior to enrollment.\n* Only patients with a T-score ≥ 75th percentile on the CPT-3 Omission Errors scale or on the BRIEF-2 Cognitive Regulation Index will be randomized.\n\nExclusion Criteria:\n\n* A history of photosensitive seizures.\n* A motor, visual, or auditory handicap that prevents computer use.\n* A mental health condition that precludes, or takes treatment precedence over, participation in the cognitive training.\n* Participants identified during the baseline assessment as having a full-scale IQ \\\u003C 80, as estimated by WASI-II (Vocabulary and Matrix Reasoning), will not be randomized.","ALL","8 Years","16 Years",{"count":82,"type":83},50,"ESTIMATED","INTERVENTIONAL",[86],"NA","This is a multicenter pilot randomized controlled trial, with an active control condition, of the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a cohort of survivors of acute lymphoblastic leukemia or brain tumor ages 8-16 who are \\> 1 year from the end of therapy.",[89,90,91,92,93],"Pediatric Cancer","Pediatric ALL","Pediatric Brain Tumor","Attention Difficulties","Cognitive Deficit in Attention","2025-01-08",{"date":96,"type":97},"2025-01-10","ACTUAL",{"date":99,"type":97},"2023-06-14",{"date":101,"type":83},"2025-08-31",{"name":5,"class":6},1]