[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637830":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":26,"responsibleParty":41,"collaborators":26,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":45,"sex":51,"minAge":52,"maxAge":26,"enrollmentInfo":53,"targetDuration":26,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":26,"overallStatus":62,"whyStopped":26,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":26},{"fullName":5,"class":6},"Chang Gung Memorial Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Experimental Group","EXPERIMENTAL","In the experimental group, participants will complete a 3-day diary documenting motor symptoms, non-motor symptoms, and medication timing. At each visit, neurological examinations and standardized Parkinson's disease (PD) assessments will be performed.\n\nAdverse events (AEs) and serious adverse events (SAEs) will be recorded throughout the study, regardless of causality, and categorized by their relationship to FMT.\n\nFollow-up assessments will be conducted at 1 week, 3 months, and 6 months after FMT. Stool samples will be collected at baseline, 3 months, and 6 months.",[13],"Procedure: Fecal microbiota transplantation",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Group","ACTIVE_COMPARATOR","In the control group, all the assessments will be conducted at the baseline, 3 months, and 6 months. Stool samples will be collected at baseline, 3 months, and 6 months.",[19],"Procedure: Not received Fecal microbiota transplantation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Fecal microbiota transplantation","All subjects in the treatment group will receive FMT once. Recipients must adhere to a low-fiber diet for three days, and pre-treatment antibiotics with Vancomycin 125 mg, administered as 2 capsules every 6 hours for 3 days. After a 24-hour washout period, they underwent colon preparation followed by FMT. During the procedure, processed 250cc microbiota fluid from healthy donors, provided by the Chang Gung fecal bank, was administered into the terminal ileum or cecum via ileocolonoscopy. To ensure safety and traceability, only a single-donor microbiota is used. After FMT, patients were instructed to lie on their right side for at least 30 minutes.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Not received Fecal microbiota transplantation","All subjects in the Control group will not receive FMT.",[15],[32],{"name":33,"affiliation":5,"role":34},"Chiung-Chu Chen, PhD.","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Siao-Chu Su, Bachelor","CONTACT","+886978835982","b9805039@cgmh.org.tw",{"type":42,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100637830","fecal-microbiota-transplantation-in-parkinsons-disease-100637830",false,"NCT07597421","Fecal Microbiota Transplantation in Parkinson's Disease.","Fecal Microbiota Transplantation for the Treatment of Patients With Parkinson's Disease.","FMT","Inclusion Criteria:\n\n1. Clinical diagnosis of idiopathic PD according to UK brain bank criteria.\n2. PD disease duration ≧5 years to avoid the possible misdiagnosis of atypical parkinsonism.\n3. Hoehn-Yahr stage 1-4\n4. Using levodopa in a currently fixed dose.\n5. Presence of motor complications (motor fluctuation or dyskinesia).\n6. Written informed consent.\n7. Age above 18.\n\nExclusion Criteria:\n\n1. Hoehn-Yahr stage 5. (wheelchair ridden or bedridden due to PD)\n2. Dementia (MMSE\\\u003C24), history of encephalitis, or brain organic lesions, including congenital or acquired structural abnormalities (which were detected through brain computed tomography scan or Magnetic Resonance Imaging) may affect neurological function, leading to various neurological deficits and mpairing the cognitive function.\n3. Current use of probiotics or in the past 3 months.\n4. For women with childbearing potential. (Female participants are suggested to prevent pregnancy during this trial and undergo a pregnancy test before enrollment.)\n5. Current need of antibiotics or use in the previous 3 months.\n6. End stage renal disease caused uremic encephalopathy or liver cirrhosis caused hepatic encephalopathy\n7. Immunocompromised state.","ALL","18 Years",{"count":54,"type":55},58,"ESTIMATED","INTERVENTIONAL",[58],"NA","Fecal microbiota transplantation (FMT) is an effective and safe treatment for Clostridioides difficile infection (CDI). Though CDI is the only indication for FMT, more and more preliminary data on FMT in neurological disorders are reported due to gut-brain axis. This study is a pilot study to apply FMT on patients with Parkinson's disease (PD). The effect of FMT on motor and non-motor symptoms in PD will be also evaluated.",[61],"Parkinson's Disease","NOT_YET_RECRUITING","2026-05-13",{"date":65,"type":66},"2026-05-19","ACTUAL",{"date":68,"type":55},"2026-09-01",{"date":70,"type":55},"2029-04-07",{"name":5,"class":6}]