[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100614648":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":39,"responsibleParty":54,"collaborators":24,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":24,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":24,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":24,"overallStatus":76,"whyStopped":24,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","SHAM_COMPARATOR","Control group (non-PRP in the conventional IUI)",[13],"Other: Sham Comparator: Control group",{"label":15,"type":16,"description":17,"interventionNames":18},"Intervention group","EXPERIMENTAL","Intervention group (Female PRP co-incubation with husband's sperm in the IUI)",[19],"Other: Female PRP co-incubation with husband's sperm in the IUI",[21,25],{"type":6,"name":22,"description":17,"armGroupLabels":23,"otherNames":24},"Female PRP co-incubation with husband's sperm in the IUI",[15],null,{"type":6,"name":26,"description":11,"armGroupLabels":27,"otherNames":24},"Sham Comparator: Control group",[9],[29],{"name":30,"affiliation":5,"role":31},"Jacqueline Pui Wah Chung","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":24,"email":36},"CONTACT","85235051537","jacquelinechung@cuhk.edu.hk",{"name":30,"role":34,"phone":38,"phoneExt":24,"email":36},"+85235051537",[40],{"facility":41,"status":24,"city":42,"state":24,"zip":24,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Department of Obstetrics & Gynaecology The Chinese University of Hong Kong","Hong Kong","China","CN",{"type":46,"coordinates":47},"Point",[48,49],114.17469,22.27832,{"lat":49,"lon":48},[52],{"name":30,"role":34,"phone":53,"phoneExt":24,"email":36},"+852 3505 1537",{"type":31,"investigatorFullName":55,"investigatorTitle":56,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Chung Pui Wah Jacqueline","Associate Professor","100614648","female-autologous-platelet-rich-plasma-prp-co-incubation-with-husbands-sperm-100614648",false,"NCT07282327","Female Autologous Platelet-Rich Plasma (PRP) Co-incubation With Husband's Sperm","The Efficacy and Safety of Female Autologous Platelet-Rich Plasma (PRP) Co-incubation With Husband's Sperm in the Intrauterine Insemination (IUI) to Improve Clinical Pregnancy Rate: A Prospective, Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients undergoing IUI cycles\n* Infertility patients aged \\>18 years old and \\\u003C 42 years old\n* BMI \\\u003C30 kg\u002Fm2\n* No sexually transmitted diseases, AIDS, syphilis and other infectious disease\n\nExclusion Criteria:\n\n* Concurrent administration of other agents such as prednisolone, intravenous immunoglobulin, or G-CSF\n* Administration of anticoagulants or NSAIDs at least 7 days before PRP infuse\n* Drug addiction\n* Urinary tract infection\n* Underlying uncontrolled diabetes or hypertension, chromosomal or uterine abnormalities, genetic, hematologic, immunological, or endocrine disorders\n* Chronic disease, systemic disease or cancers\n* Blood diseases (sepsis, thrombocytopenia)\n* Haemoglobin \\\u003C 11g\u002FdL, platelet count \\\u003C 150000 mm3\n* Poor sperm samples (raw sample TMS \\\u003C5 x 106)\n* Smoking and drinking alcoholic beverages on the day of IUI\n* Fever on the day of IUI","ALL","18 Years","42 Years",{"count":68,"type":69},288,"ESTIMATED","INTERVENTIONAL",[72],"NA","Hypotheses:\n\nWe hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate.\n\nAims:\n\n* To determine if the use of female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm in the IUI will show higher clinical pregnancy rate (CPR). Clinical pregnancy rate as determined by a positive serum beta-hCG test result and at least one gestational sac at 6 weeks gestation\n* To assess the safety of female PRP co-incubation with husband's sperm in the IUI.\n\nPrimary outcome:\n\nTo compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group.\n\nSecondary outcomes:\n\n* To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other complications such as ectopic pregnancy and molar pregnancy\n* To evaluate the sperm quality between the intervention group and control group\n\nData analysis: Data analysis will be performed using Statistical Packages of Social Sciences for Windows\n\nExpected results: The investigators expect that a 50% pregnancy rate increase after the application of female PRP co-incubation with husband's sperm in the IUI",[75],"Reproductive Issues","NOT_YET_RECRUITING","2025-12-02",{"date":79,"type":80},"2025-12-15","ACTUAL",{"date":82,"type":69},"2025-12-10",{"date":84,"type":69},"2027-08-31",{"name":5,"class":6},1]