[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100428996":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":29,"centralContacts":33,"locations":43,"responsibleParty":64,"collaborators":10,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":46,"whyStopped":10,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"University Hospital, Tours","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"In Vitro Fertilisation protocol",null,"Women followed in the department for an in vitro fertilisation protocol",[13,14,15],"Other: Blood sample","Other: Urine sample","Other: Follicular fluid and granulosa cells sample",[17,21,25],{"type":6,"name":18,"description":19,"armGroupLabels":20,"otherNames":10},"Blood sample","Additional blood sampling at the end of ovarian stimulation monitoring (the eve of the oocyte pick-up)",[9],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"Urine sample","Collection of the first urine in the morning on the day of the oocyte pick-up",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Follicular fluid and granulosa cells sample","Collection of follicular fluid and granulosa cells during oocyte pick-up.",[9],[30],{"name":31,"affiliation":5,"role":32},"Fabrice GUERIF, MD-PhD","PRINCIPAL_INVESTIGATOR",[34,39],{"name":31,"role":35,"phone":36,"phoneExt":37,"email":38},"CONTACT","02.47.47.84.76","+33","fabrice.guerif@univ-tours.fr",{"name":40,"role":35,"phone":41,"phoneExt":37,"email":42},"Virginie MAILLARD, PhD","02.47.42.79.71","virginie.maillard@inrae.fr",[44],{"facility":45,"status":46,"city":47,"state":10,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Department of Reproductive Medicine and Biology, Univesity Hospital, Tours","RECRUITING","Tours","37044","France","FR",{"type":52,"coordinates":53},"Point",[54,55],0.70398,47.39484,{"lat":55,"lon":54},[58,59,61,62],{"name":31,"role":35,"phone":10,"phoneExt":10,"email":10},{"name":60,"role":35,"phone":10,"phoneExt":10,"email":10},"Claire VIGNAULT, MD",{"name":31,"role":32,"phone":10,"phoneExt":10,"email":10},{"name":60,"role":63,"phone":10,"phoneExt":10,"email":10},"SUB_INVESTIGATOR",{"type":65,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100428996","female-fertility-environmental-agents-and-stress-oxidant-100428996",false,"NCT04866329","Female Fertility, Environmental Agents and Stress Oxidant","FERTilité féminine, Agents ENvironnementaux et Stress OXydant","FERTENOX","Inclusion Criteria:\n\n* Woman aged 18 to 43 years old\n* First oocyte puncture (IVF rank = 1)\n\nExclusion Criteria:\n\n* Opposition to data processing\n* IVF rank equal or greater than 2\n* Egg donation\n* Intracytoplasmic Sperm Injection with testicular biopsy\n* Intracytoplasmic Sperm Injection with self-preservation straw\n* Sperm donation","FEMALE","18 Years","43 Years",{"count":78,"type":79},500,"ESTIMATED","OBSERVATIONAL","Synthetic products used in industrial, pharmaceutical, agro-alimentary or agricultural fields are found in our environment. Thus, humans could be simultaneously exposed to several of these pollutants. Furthermore, these environmental agents exert or could exert adverse actions on fertility, by altering gamete and embryo quality through endocrine disruptor effects or through increase in oxidative stress in gonads (cellular pathway known to be involved in several human reproductive pathologies).\n\nIn this context, the objectives of the present project are to obtain descriptive and analytical data on woman and oocyte exposure to several environmental agents (bisphenols, ethynylestradiol and glyphosate). The relation between these pollutant measures in follicular fluid and urine (from women receiving follow-up of in vitro fertilization (IVF) protocol in the University hospital of Tours, France) and the oocyte quality, the IVF and pregnancy successes will be studied. Several oxidative stress biomarkers in blood and follicular fluid will be also measured for these women, who will complete a questionnaire on their lifestyles. Finally, thanks to in vitro approaches, the effects and the mechanisms of action (including oxidative stress) of these pollutants (alone or in cocktails) will be studied on granulosa cells from these patients.",[83],"Female Infertility",[85,86,87,88,89,90,91,92,93],"Environmental pollutants","Bisphenols","Ethynylestradiol","Glyphosate","Oxidative stress","Oocyte and embryo quality","In vitro fertilization","Pregnancy","Follicular fluid and urine biomarkers","2024-07-24",{"date":96,"type":97},"2024-07-25","ACTUAL",{"date":99,"type":97},"2021-12-08",{"date":101,"type":79},"2027-12",{"name":5,"class":6},1]