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stenting",{"label":15,"type":16,"description":17,"interventionNames":18},"drug group with FFR ≥ 0.8","ACTIVE_COMPARATOR","Drug-induced hyperemic FFR ≥0.80",[19],"Drug: Randomized to optimal medical therapy (OMT)",{"label":21,"type":6,"description":17,"interventionNames":22},"FFR \u003C 0.8",[23],"Device: stent implantation",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Randomized to stenting","Patients with pharmacologically induced renal FFR ≥ 0.80 will be randomly assigned to receive either stent implantation.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"stent implantation","Patients with pharmacologically induced renal FFR \\\u003C 0.80 will receive stent implantatio.",[21],{"type":36,"name":37,"description":38,"armGroupLabels":39,"otherNames":30},"DRUG","Randomized to optimal medical therapy (OMT)","Patients with pharmacologically induced renal FFR ≥ 0.80 will be randomly assigned to optimal medical therapy.",[15],[41,46],{"name":42,"role":43,"phone":44,"phoneExt":30,"email":45},"Xiongjing Jiang","CONTACT","86-010-88322387","jiangxiongjing@163.com",{"name":47,"role":43,"phone":48,"phoneExt":30,"email":49},"Hui Dong","86-010-88322385","donghui666@sina.com",[51,69,80,94,109,116,131,141,148,163,178,193,203,218,232,245,260,278,292,306],{"facility":52,"status":30,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"The First Affiliated Hospital of Sun Yat-sen University","Guangzhou","Guangdong","510000","China","CN",{"type":59,"coordinates":60},"Point",[61,62],113.25,23.11667,{"lat":62,"lon":61},[65],{"name":66,"role":43,"phone":67,"phoneExt":30,"email":68},"Wenhao Xia","020-87755766","xiawhao@mail.sysu.edu.cn",{"facility":70,"status":30,"city":53,"state":54,"zip":71,"country":56,"countryCode":57,"cosmosGeoPoint":72,"geoPoint":74,"contacts":75},"The First Affiliated Hospital of Guangzhou Medical 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University","Harbin","Heilongjiang","150086",{"type":59,"coordinates":100},[101,102],126.65,45.75,{"lat":102,"lon":101},[105],{"name":106,"role":43,"phone":107,"phoneExt":30,"email":108},"Shuo Zhang","18645056661","zhangshuoemail@163.com",{"facility":95,"status":30,"city":96,"state":97,"zip":98,"country":56,"countryCode":57,"cosmosGeoPoint":110,"geoPoint":112,"contacts":113},{"type":59,"coordinates":111},[101,102],{"lat":102,"lon":101},[114],{"name":115,"role":43,"phone":107,"phoneExt":30,"email":108},"Zhiyu Shi",{"facility":117,"status":30,"city":118,"state":119,"zip":120,"country":56,"countryCode":57,"cosmosGeoPoint":121,"geoPoint":125,"contacts":126},"Fuwai Central China Cardiovascular Hospital","Zhengzhou","Henan","450000",{"type":59,"coordinates":122},[123,124],113.64861,34.75778,{"lat":124,"lon":123},[127],{"name":128,"role":43,"phone":129,"phoneExt":30,"email":130},"Qiuping 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University","Dalian","Liaoning","116001",{"type":59,"coordinates":184},[185,186],121.60222,38.91222,{"lat":186,"lon":185},[189],{"name":190,"role":43,"phone":191,"phoneExt":30,"email":192},"Minglian Gong","0411-62896223","gongml777@126.com",{"facility":194,"status":30,"city":180,"state":181,"zip":30,"country":56,"countryCode":57,"cosmosGeoPoint":195,"geoPoint":197,"contacts":198},"Frist Aiffiliated Hospital of Dalian Medical University",{"type":59,"coordinates":196},[185,186],{"lat":186,"lon":185},[199],{"name":200,"role":43,"phone":201,"phoneExt":30,"email":202},"Ying Zhang","18098876188","zy114129@sina.com",{"facility":204,"status":30,"city":205,"state":206,"zip":207,"country":56,"countryCode":57,"cosmosGeoPoint":208,"geoPoint":212,"contacts":213},"China-Japan Union Hospital of Jilin University","Changchun","Lilin","130033",{"type":59,"coordinates":209},[210,211],125.32278,43.88,{"lat":211,"lon":210},[214],{"name":215,"role":43,"phone":216,"phoneExt":30,"email":217},"Yuquan He","13944145413","liuxueyan@jlu.edu.cn",{"facility":219,"status":30,"city":220,"state":221,"zip":30,"country":56,"countryCode":57,"cosmosGeoPoint":222,"geoPoint":226,"contacts":227},"Qilu Hospital of Shandong University","Jinan","Shandong",{"type":59,"coordinates":223},[224,225],116.99722,36.66833,{"lat":225,"lon":224},[228],{"name":229,"role":43,"phone":230,"phoneExt":30,"email":231},"Peili Bu","18560086596","bupeili@medmail.com.cn",{"facility":233,"status":30,"city":234,"state":221,"zip":30,"country":56,"countryCode":57,"cosmosGeoPoint":235,"geoPoint":239,"contacts":240},"Qingdao Hospital University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital)","Qingdao",{"type":59,"coordinates":236},[237,238],120.38042,36.06488,{"lat":238,"lon":237},[241],{"name":242,"role":43,"phone":243,"phoneExt":30,"email":244},"Nan Jia","17669783012","jiananchina@qq.com",{"facility":246,"status":30,"city":247,"state":248,"zip":249,"country":56,"countryCode":57,"cosmosGeoPoint":250,"geoPoint":254,"contacts":255},"The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu, Chengdu, China","Chengdu","Sichuan","610031",{"type":59,"coordinates":251},[252,253],104.06667,30.66667,{"lat":253,"lon":252},[256],{"name":257,"role":43,"phone":258,"phoneExt":30,"email":259},"Zhen Zhang","13708042927","31350377@qq.com",{"facility":261,"status":30,"city":262,"state":30,"zip":263,"country":56,"countryCode":57,"cosmosGeoPoint":264,"geoPoint":268,"contacts":269},"Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College","Beijing","100037",{"type":59,"coordinates":265},[266,267],116.39723,39.9075,{"lat":267,"lon":266},[270,272,275],{"name":47,"role":43,"phone":271,"phoneExt":30,"email":49},"15810161393",{"name":273,"role":274,"phone":30,"phoneExt":30,"email":30},"Xiongjing Jiang, MD","PRINCIPAL_INVESTIGATOR",{"name":276,"role":277,"phone":30,"phoneExt":30,"email":30},"Hui Dong, MD,PhD","SUB_INVESTIGATOR",{"facility":279,"status":30,"city":280,"state":30,"zip":281,"country":56,"countryCode":57,"cosmosGeoPoint":282,"geoPoint":286,"contacts":287},"Department of Cardiovascular Medicine, Cardiovascular Research Center , The First Affiliated Hospital of Chongqing Medical University","Chongqing","400016",{"type":59,"coordinates":283},[284,285],106.55771,29.56026,{"lat":285,"lon":284},[288],{"name":289,"role":43,"phone":290,"phoneExt":30,"email":291},"Jing Chang","18983289612","1584105002@qq.com",{"facility":293,"status":30,"city":294,"state":30,"zip":295,"country":56,"countryCode":57,"cosmosGeoPoint":296,"geoPoint":300,"contacts":301},"Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine","Shanghai","200025",{"type":59,"coordinates":297},[298,299],121.45806,31.22222,{"lat":299,"lon":298},[302],{"name":303,"role":43,"phone":304,"phoneExt":30,"email":305},"Jianzhong Xu","13761452329","jianzhongxv@outlook.com",{"facility":307,"status":30,"city":308,"state":30,"zip":309,"country":56,"countryCode":57,"cosmosGeoPoint":310,"geoPoint":314,"contacts":315},"TianJin First Central Hospital","Tianjin","300192",{"type":59,"coordinates":311},[312,313],117.17667,39.14222,{"lat":313,"lon":312},[316],{"name":317,"role":43,"phone":318,"phoneExt":30,"email":319},"Chengzhi Lu","022-23629373","Lucz8@126.com",{"type":274,"investigatorFullName":42,"investigatorTitle":321,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"professor","100632255","ffr-guided-revascularization-in-atherosclerotic-renal-artery-stenosis-100632255",false,"NCT07511309","FFR-Guided Revascularization in Atherosclerotic Renal Artery Stenosis","Fractional Flow Reserve-Guided Revascularization in Atherosclerotic Renal Artery Stenosis: A Randomized Controlled Trial","FARS","Inclusion Criteria:\n\n1. Renal artery diameter stenosis ≥60%;\n2. Office systolic blood pressure ≥ 160 mmHg and\u002For office diastolic blood pressure ≥ 100 mmHg on at least two separate days without antihypertensive medication, or office systolic blood pressure ≥ 140 mmHg and\u002For office diastolic blood pressure ≥ 90 mmHg while on three antihypertensive drugs at conventional doses;\n3. Serum creatinine \\\u003C 264 μmol\u002FL (3.0 mg\u002FdL);\n4. Affected kidney length ≥ 7.0 cm, with residual glomerular filtration rate (GFR) ≥ 10 mL\u002Fmin;\n\nExclusion Criteria:\n\n1. Unstable clinical condition rendering the patient intolerant to revascularisation therapy;\n2. Urinary protein ≥2+;\n3. Contrast medium allergy;\n4. Renal artery anatomy unsuitable for revascularisation therapy;\n5. Reference vessel diameter \\\u003C3.5mm or \\>8mm.\n6. Patients with non-atherosclerotic renal artery stenosis (such as fibromuscular dysplasia or Takayasu arteritis);\n7. Reference vessel diameter \\\u003C 3.5 mm or \\> 8 mm.","ALL","40 Years","80 Years",{"count":334,"type":335},300,"ESTIMATED","INTERVENTIONAL",[338],"NA","For patients with atherosclerotic renal artery stenosis, the results of randomized controlled trials published in recent years have failed to demonstrate that renal artery stenting is superior to optimal medical therapy. However, these studies still have limitations.\n\nFractional flow reserve (FFR) has been extensively studied in coronary artery disease, and it has been established that FFR-guided revascularization is superior to both angiography-guided percutaneous coronary intervention and medical therapy alone. Whether FFR can guide interventional treatment in patients with renal artery stenosis and hypertension is currently a hot topic in the field of renal artery stenosis research.\n\nEligible patients meeting the inclusion criteria were enrolled. Pharmacologically induced FFR values were measured as the baseline. Patients with FFR ≥ 0.8 were randomly assigned to either the medical therapy group or the stenting group, while patients with FFR \\\u003C 0.8 underwent stent implantation. Changes in eGFR, 24-hour systolic blood pressure, and 24-hour diastolic blood pressure from baseline to 12 months were compared among the groups.",[341,342,343,344],"Atherosclerotic Renal Artery Stenosis","Fractional Flow Reserve","Optimal Medical Therapy","Stent Implantation",[341,342,343],"NOT_YET_RECRUITING","2026-04-27",{"date":349,"type":350},"2026-04-30","ACTUAL",{"date":352,"type":335},"2026-03-31",{"date":354,"type":335},"2028-03-31",{"name":5,"class":6},20]