[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100617527":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":79,"collaborators":82,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":87,"sex":93,"minAge":94,"maxAge":95,"enrollmentInfo":96,"targetDuration":26,"studyType":99,"phases":100,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":64,"whyStopped":26,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":122},{"fullName":5,"class":6},"National Children's Medical Center, Uzbekistan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"F-TIP Urethroplasty","EXPERIMENTAL","Participants will undergo fibrin-enhanced tubularized incised plate (F-TIP) urethroplasty. Autologous platelet-rich fibrin will be prepared intraoperatively and applied to the incised urethral plate and fixed with PDS 6\u002F0-7\u002F0 suture prior to tubularization.",[13],"Procedure: Fibrin-Enhanced TIP Urethroplasty",{"label":15,"type":16,"description":17,"interventionNames":18},"G-TIP Urethroplasty","ACTIVE_COMPARATOR","Participants will undergo grafted tubularized incised plate (G-TIP) urethroplasty using standard graft augmentation techniques for unfavorable urethral plates.",[19],"Procedure: Grafted TIP Urethroplasty",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Fibrin-Enhanced TIP Urethroplasty","Tubularized incised plate urethroplasty augmented with autologous platelet-rich fibrin membrane applied to the incised urethral plate prior to tubularization.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Grafted TIP Urethroplasty","Graft-augmented tubularized incised plate urethroplasty performed using standard surgical techniques for unfavorable urethral plates.",[15],[32],{"name":33,"affiliation":34,"role":35},"Zafar Abdullaev, MD, PhD","National Children's Medical Center, Tashkent, Uzbekistan","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Zafar Abdullaev, MD PhD","CONTACT","+998-90-909-9911","Abdullaev.med@gmail.com",[43,62],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Dr. Cipto Mangunkusumo Hospital","NOT_YET_RECRUITING","Jakarta","DKI Jakarta","10430","Indonesia","ID",{"type":52,"coordinates":53},"Point",[54,55],106.84513,-6.21462,{"lat":55,"lon":54},[58],{"name":59,"role":39,"phone":60,"phoneExt":26,"email":61},"Dr. Cipto Mangunkusumo General Hospital Jakarta, Indonesia Pediatric Urology Department","+6285935071599","anggariskyraharja@gmail.com",{"facility":63,"status":64,"city":65,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":73,"contacts":74},"National Children's Medical Center","RECRUITING","Tashkent","100020","Uzbekistan","UZ",{"type":52,"coordinates":70},[71,72],69.21627,41.26465,{"lat":72,"lon":71},[75],{"name":76,"role":39,"phone":77,"phoneExt":77,"email":78},"National Children's Medical Center Pediatric Urology department","+998950047777","abdullaev.med@gmail.com",{"type":35,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Zafar Abdullaev","Head of the Pediatric Urology Department",[83],{"name":84,"class":6},"Dr Cipto Mangunkusumo General Hospital","100617527","fibrin-enhanced-tip-versus-grafted-tip-urethroplasty-in-distal-hypospadias-100617527",false,"NCT07319780","Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal Hypospadias","A Multicenter Randomized Controlled Trial Comparing Fibrin-Enhanced Tubularized Incised Plate (F-TIP) and Grafted Tubularized Incised Plate (G-TIP) Urethroplasty in Distal Hypospadias With Unfavorable Urethral Plates","FTIP-RCT","Inclusion Criteria:\n\n* Male children aged 6 months to 84 months\n* Primary or redo distal hypospadias\n* Unfavorable urethral plate\n* Penile curvature less than 45 degrees after degloving\n* Eligibility for tubularized incised plate urethroplasty\n\nExclusion Criteria:\n\n* Disorders of sex development or ambiguous genitalia\n* Severe penile curvature requiring urethral plate transection\n* Previous graft-based urethroplasty\n* Active local or systemic infection at the time of surgery\n* Known bleeding or platelet disorders\n* Inability to comply with postoperative follow-up","MALE","6 Months","84 Months",{"count":97,"type":98},100,"ESTIMATED","INTERVENTIONAL",[101],"NA","Hypospadias is a common congenital condition in boys in which the opening of the urethra is located on the underside of the penis. Distal hypospadias is the most common form and is usually treated surgically using tubularized incised plate (TIP) urethroplasty. In boys with an unfavorable urethral plate, graft-augmented techniques (G-TIP) are often used; however, postoperative complications such as urethrocutaneous fistula and narrowing of the urethral opening (meatal stenosis) may still occur.\n\nPlatelet-rich fibrin (PRF) is a biological material obtained from the patient's own blood that contains natural growth factors and may help improve tissue healing. This study aims to evaluate whether the use of PRF during surgery can reduce postoperative complications and improve surgical outcomes in children undergoing hypospadias repair.",[104,105],"Distal Hypospadias","Hypospadias",[107,108,109,110,111,112],"Hypospadias repair","Tubularized incised plate","Platelet-rich fibrin","PRF","Grafted TIP","Pediatric urology","2026-01-28",{"date":115,"type":116},"2026-01-30","ACTUAL",{"date":118,"type":116},"2026-01-05",{"date":120,"type":98},"2028-12-25",{"name":5,"class":6},2]