[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556598":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":30,"centralContacts":35,"locations":44,"responsibleParty":81,"collaborators":10,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":91,"sex":92,"minAge":93,"maxAge":10,"enrollmentInfo":94,"targetDuration":10,"studyType":97,"phases":10,"briefSummary":98,"conditions":99,"keywords":10,"overallStatus":47,"whyStopped":10,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":110},{"fullName":5,"class":6},"Hospital Ambroise Paré Paris","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients with fibromyalgia",null,"Patients with fibromyalgia based on ACR criteria",[13],"Diagnostic Test: Skin punch biopsy to demonstrate small fiber neuropathy",{"label":15,"type":10,"description":16,"interventionNames":17},"Patients with other chronic pain (paired for the other groups)","Patients with chronic pain other than fibromyalgia and neuropathic pain, eg nociplastic pains or nociceptive pains",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Paired healthy subjects","Healthy subjects paired for gender and age",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DIAGNOSTIC_TEST","Skin punch biopsy to demonstrate small fiber neuropathy","Skin punch biopsy to assess intrapidermal nerve fiber density",[19,9,15],[29],"Other diagnostic tests will include laser evoked potentiels, quantitative sensory testing, sudoscan, and confocal corneal microscopu",[31],{"name":32,"affiliation":33,"role":34},"Nadine ATTAL, MD PhD","APHP","PRINCIPAL_INVESTIGATOR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":10,"email":39},"CONTACT","0033149095931","nadine.attal@aphp.fr",{"name":41,"role":37,"phone":42,"phoneExt":10,"email":43},"Didier BOUHASSIRA, MD PhD","0033149094556","didier.bouhassira@inserm.fr",[45,66],{"facility":46,"status":47,"city":48,"state":10,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"Inserm U987","RECRUITING","Boulogne-Billancourt","92100","France","FR",{"type":53,"coordinates":54},"Point",[55,56],2.24128,48.83545,{"lat":56,"lon":55},[59,61,64],{"name":60,"role":37,"phone":38,"phoneExt":10,"email":39},"Nadine ATTAL",{"name":62,"role":63,"phone":10,"phoneExt":10,"email":10},"Didier BOUHASSIRA","SUB_INVESTIGATOR",{"name":65,"role":34,"phone":10,"phoneExt":10,"email":10},"Serge PERROT",{"facility":67,"status":47,"city":68,"state":10,"zip":69,"country":50,"countryCode":51,"cosmosGeoPoint":70,"geoPoint":74,"contacts":75},"Centre d'Evaluation et de Traitement de la douleur","Paris","75014",{"type":53,"coordinates":71},[72,73],2.3488,48.85341,{"lat":73,"lon":72},[76,79],{"name":65,"role":37,"phone":77,"phoneExt":10,"email":78},"0033158414141","serge.perrot@aphp.fr",{"name":80,"role":63,"phone":10,"phoneExt":10,"email":10},"Anne-Priscille TROUVIN",{"type":34,"investigatorFullName":60,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Coordinator","100556598","fibromyalgia-and-small-fiber-neuropathy-100556598",false,"NCT06527183","Fibromyalgia and Small Fiber Neuropathy","Fibromyalgia and Small Fiber Neuropathy : Which Prevalence and Which Relationship With Pain ?","FIBRO-NEP","Inclusion Criteria:\n\n* patients over 18 years of age with no age limit -\n* having given their signed consent to take part in the study\n* affiliated to the French social security system\n* able to be followed for the entire duration of the study\n* reading and understanding French\n* accepting the principle of the study and able to comply with its conditions\n* suffering from chronic pain for at least six months of at least moderate intensity (≥ 4\u002F10)\n* fibromyalgia detected by the FiRST questionnare and defined by the revised diagnostic criteria of the WHO or chronic nociceptive or nociplastic pain without associated fibromyalgia.\n* chronic pain for at least 6 months of at least moderate intensity (≥ 4\u002F10)\n* untreated or with stable analgesic treatment for at least 2 weeks prior to inclusion- normal neurological examination at inclusion\n\nExclusion Criteria:\n\n* litigation or compensation-seeking\n* cancer for less than 2 years\n* known cause of small-fiber neuropathy such as diabetes, systemic disease, hypothyroidism, alcohol, renal failure, genetic disease\n* clinical or EMG neuropathy\n* peripheral or central nervous system pathology with or without associated neuropathic pain\n* uncontrolled chronic pathology such as : morbid obesity, sleep apnea, uncontrolled hypertension, etc. - psychosis, previous suicide attempt\n* drug or psychoactive substance abuse\n* cognitive or psychological disorders incompatible with compliance with and\u002For understanding of the protocol\n* participation in another biomedical research protocol.",true,"ALL","18 Years",{"count":95,"type":96},150,"ESTIMATED","OBSERVATIONAL","The primary objective of this study will be to assess the proportion of fibromyalgia patients with diffuse small-fiber neuropathy (i.e. in the upper and lower limbs) and compare this proportion to patients with other chronic pains (nociplastic, nociceptive) and with healthy controls. Our analysis will be based on the demonstration of structural abnormalities of small nerve fibers by means of skin biopsy, but also of functional abnormalities using four validated tests commonly used in this field: quantitative sensory testing (QST), laser evoked potential recordings, Sudoscan and confocal corneal microscopy. It will thus be possible to verify whether or not patients with small fiber neuropathy have a particular clinical profile in terms of pain, physical activity, comorbidities or pain impact.",[100],"Chronic Pain Syndrome","2025-09-03",{"date":103,"type":104},"2025-09-10","ACTUAL",{"date":106,"type":104},"2022-01-04",{"date":108,"type":96},"2026-05",{"name":5,"class":6},2]