[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627579":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":13,"locations":19,"responsibleParty":33,"collaborators":7,"id":35,"slug":36,"hasResults":37,"nctId":38,"briefTitle":39,"officialTitle":40,"acronym":41,"eligibilityCriteria":42,"healthyVolunteers":37,"sex":43,"minAge":44,"maxAge":7,"enrollmentInfo":45,"targetDuration":7,"studyType":48,"phases":7,"briefSummary":49,"conditions":50,"keywords":54,"overallStatus":56,"whyStopped":7,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},{"fullName":5,"class":6},"Institute of Mountain Emergency Medicine","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DRUG","Iloprost (Ilomedin, BAYQ6256)","Begin Iloprost intravenous infusion as soon as feasible for all Grade 2-4 frostbite cases (optimally within 24-72 hours of injury, but it can be beneficial even if started later). Iloprost is a prostacyclin analogue vasodilator that improves blood flow and inhibits platelet aggregation, thereby counteracting frostbite's ischemic and thrombotic components.\n\nKey points for Iloprost administration:\n\n* Dosage and preparation: Iloprost is supplied in ampoules of 50mcg\u002F0.5mL. Dilute 50 mcg into a 250mL bag of D5W (5% dextrose) to create a 0.2 mcg\u002FmL solution. Iloprost infusion should be administered via a dedicated IV line using an infusion pump.\n* Infusion protocol: Start iloprost infusion at 10 mL\u002Fhour (which delivers 2 mcg\u002Fhour, assuming the 0.2 mcg\u002FmL dilution). Every 30 minutes, increase infusion rate by 10 mL\u002Fhour, as tolerated, until the maximum rate appropriate for the patient's weight is reached (40-50 kg: up to 30 mL\u002Fhour; 51-74 kg: up to 40 mL\u002Fhour; ≥75 kg: up to 50 mL\u002Fhour.",[14],{"name":15,"role":16,"phone":17,"phoneExt":7,"email":18},"Lea AJ Duempelmann","CONTACT","+39 0471 055 726","lea.duempelmann@eurac.edu",[20],{"facility":21,"status":7,"city":22,"state":23,"zip":24,"country":25,"countryCode":26,"cosmosGeoPoint":27,"geoPoint":32,"contacts":7},"Eurac Research, Institute of Mountain Emergency Medicine","Bolzano","BZ","39100","Italy","IT",{"type":28,"coordinates":29},"Point",[30,31],11.33982,46.49067,{"lat":31,"lon":30},{"type":34,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR","100627579","field-study-on-intravenous-iloprost-for-treatment-of-severe-frostbite-at-high-altitude-100627579",false,"NCT07450469","Field Study on Intravenous Iloprost for Treatment of Severe Frostbite at High Altitude","High-Altitude Iloprost Feasibility Study for Treatment of Frostbite","HAI-Frost","Inclusion Criteria:\n\n* Frostbite grade 3\u002F4 eligible for Iloprost\n* \\\u003C72h of thawing\n* min. age of 18 years\n* provision of written informed consent\n\nExclusion Criteria:\n\n* age \\\u003C18 years\n* general contraindication\n* pregnancy\n* inability\u002Fdenial to provide informed consent","ALL","18 Years",{"count":46,"type":47},10,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn whether intravenous iloprost treatment for severe frostbite (grades 3-4) is feasible and safe when delivered in pre-hospital, remote high-altitude settings.\n\nThe main questions it aims to answer are:\n\n* Is it feasible to initiate and deliver guideline-based intravenous iloprost for grade 3-4 frostbite at high altitude and what logistical barriers arise?\n* Does field-based initiation of iloprost increase tissue preservation and reduce amputations (compared to historical cases from similar settings)?\n\nParticipants receiving Iloprost as part of a frostbite treatment will be followed up after discharge as well as 6, 12 and 18 months to assess tissue preservation and long-term sequelae from the initial frostbite injury.",[51,52,53],"Frostbite","Altitude","Field Physician Care",[55],"iloprost","NOT_YET_RECRUITING","2026-03-05",{"date":59,"type":60},"2026-03-09","ACTUAL",{"date":62,"type":47},"2026-05",{"date":64,"type":47},"2028-05",{"name":5,"class":6},1]