[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100564582":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":37,"responsibleParty":51,"collaborators":55,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":24,"eligibilityCriteria":67,"healthyVolunteers":68,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":24,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":39,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"University of Kentucky","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"No Exercise","ACTIVE_COMPARATOR","Participants will undergo a 30d Unilateral Lower Limb Suspension (ULLS) without exercise",[13],"Other: No Exercise",{"label":15,"type":16,"description":17,"interventionNames":18},"velocity-based FIT (VBFIT)","EXPERIMENTAL","Participants will undergo a 30d Unilateral Lower Limb Suspension (ULLS) with exercise",[19],"Other: velocity-based FIT (VBFIT)",[21,25],{"type":6,"name":15,"description":22,"armGroupLabels":23,"otherNames":24},"Participants will ambulate unilaterally using a shoe modified with a 5cm rocker-style stack and forearm crutches for the duration of the study.\n\nAll participants will complete two testing sessions prior to ULLS, one testing session at day 13, and two testing sessions at the end of the study. Those assigned to the exercise group will perform a both high-intensity resistance and aerobic exercise three times per week",[15],null,{"type":6,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"Participants will ambulate unilaterally using a shoe modified with a 5cm rocker-style stack and forearm crutches for the duration of the study.\n\nAll participants will complete two testing sessions prior to ULLS, one testing session at day 13, and two testing sessions at the end of the study.",[9],[29],{"name":30,"affiliation":5,"role":31},"Lance Bollinger, PhD","PRINCIPAL_INVESTIGATOR",[33],{"name":30,"role":34,"phone":35,"phoneExt":24,"email":36},"CONTACT","8592577904","lance.bollinger@uky.edu",[38],{"facility":5,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":24},"RECRUITING","Lexington","Kentucky","40506","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-84.47772,37.98869,{"lat":49,"lon":48},{"type":52,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Lance Bollinger","Associate Professor",[56,58],{"name":57,"class":6},"University of Louisville",{"name":59,"class":60},"National Aeronautics and Space Administration (NASA)","FED","100564582","fit-exercise-in-30d-of-ulls-induced-muscle-disuse-100564582",false,"NCT06631053","FIT Exercise in 30d of ULLS-induced Muscle Disuse","Use of Velocity Monitoring to Prescribe Appropriate Flywheel-based Inertial Training (FIT) Workloads for Exercise in Space Flight","Inclusion Criteria:\n\n* Regularly engaging in aerobic exercise (\\> 150min\u002Fwk) and resistance exercise (\\>1 time per week) for the past 12 months\n* Education greater than or equal to bachelor's degree (any field)\n\nExclusion Criteria:\n\n* Waist circumference \\\u003C 55cm or \\> 90cm (F) and \\\u003C 75cm or \\> 100cm (M)\n* Body mass index \\\u003C 18.5 or \\> 29.9\n* Shoe size \\\u003C 25 or \\>29cm.\n* Not regularly engaging in exercise for previous 12 months\n* Tobacco use within previous 6 months\n* Blood clotting disorder\n* Heart arrhythmia\n* Implanted device which could negatively be affected by electrical impulse or strong magnetic field such as pacemaker, internal defibrillator, or cochlear implant\n* Diagnosed cardiovascular, pulmonary, renal, or metabolic disease\n* Pregnancy (within previous 6 months)\n* Oral contraceptive use (within previous three months)\n* High resting blood pressure (\\>140 systolic and\u002For \\> 90 diastolic)\n* Currently or previously undergone gender-affirming therapy (hormone therapy or sexual reassignment surgery)\n* Low back or leg injury in previous 6 months\n* Currently taking medication to assist with sleep\n* Muscle, bone, or joint injury that limits physical activity within previous 6 months\n* Neurological disorder which affects balance (such as multiple sclerosis or Parkinson's disease)",true,"ALL","35 Years","45 Years",{"count":73,"type":74},16,"ESTIMATED","INTERVENTIONAL",[77],"NA","This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical de-conditioning including loss of voluntary muscle strength, aerobic capacity, and balance regulation.",[80,81],"Muscle Atrophy","Muscle Weakness",[83,84,85,86],"spaceflight","unweighting","disuse","exercise","2025-10-22",{"date":89,"type":90},"2025-10-24","ACTUAL",{"date":92,"type":90},"2024-10-23",{"date":94,"type":74},"2026-09-01",{"name":53,"class":6},1]