[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626013":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":24,"locations":28,"responsibleParty":50,"collaborators":24,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":24,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":24,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":30,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Ankara Etlik City Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"FCV Group","ACTIVE_COMPARATOR","Patients allocated to the FCV group will receive intraoperative mechanical ventilation using a flow-controlled ventilation mode during surgery under general anesthesia. %50 FiO₂ will be applied, and a driving pressure of 12 cmH₂O will be used.\n\nFollowing insufflation, the patient's FiO₂ will be maintained between 0.8 and 1.0 for 20 minutes.\n\nAfter the 20th minute, ventilator settings will be returned to the baseline values.\n\nTidal volume will be generated and recorded by the ventilator according to the driving pressure and the patient's lung mechanics.\n\nMinute ventilation will be adjusted based on the target tidal volume. The target tidal volume will be set at 6-8 mL\u002Fkg (7 mL\u002Fkg) with a respiratory rate of 12 breaths\u002Fmin.\n\nPositive end-expiratory pressure (PEEP) will be maintained at 5 cmH₂O. The respiratory rate will be further titrated to maintain ETCO₂ between 35 and 40 mmHg.",[13],"Procedure: FCV Group",{"label":15,"type":10,"description":16,"interventionNames":17},"VCV Group","Patients allocated to the VCV group will receive intraoperative mechanical ventilation using a conventional volume-controlled ventilation mode throughout surgery under general anesthesia. Anesthetic induction, monitoring, and perioperative management will follow the same standardized clinical protocols as those used in the FCV group. Ventilatory parameters, including peak and plateau airway pressures and arterial blood gas measurements, will be collected at identical predefined intraoperative time points. This group serves as the comparator arm for evaluating the effects of volume-controlled ventilation on airway pressures and oxygenation in these patients.",[18],"Procedure: VCV Group",[20,25],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Patients allocated to the FCV group will receive intraoperative mechanical ventilation using a flow-controlled ventilation mode during surgery under general anesthesia. Patients will be started on ventilation after intubation with 50% oxygen, driving pressure 12, PEEP 5, and a 1:1 inspiration\u002Fexpiratory ratio.",[9],null,{"type":21,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Patients allocated to the VCV group will receive intraoperative mechanical ventilation using a conventional volume-controlled ventilation mode throughout surgery under general anesthesia. Patients will be started on ventilation after intubation with 50% oxygen, 7 ml\u002Fideal body weight tidal volume, PEEP 5, 12 breaths per minute frequency, and a 1:2 inspiration\u002Fexpiration ratio.",[15],[29],{"facility":5,"status":30,"city":31,"state":24,"zip":32,"country":33,"countryCode":24,"cosmosGeoPoint":34,"geoPoint":39,"contacts":40},"RECRUITING","Ankara","06000","Turkey (Türkiye)",{"type":35,"coordinates":36},"Point",[37,38],32.85427,39.91987,{"lat":38,"lon":37},[41,46],{"name":42,"role":43,"phone":44,"phoneExt":24,"email":45},"Atakan Sezgi, M.D.","CONTACT","00905323327000","kansezgi@gmail.com",{"name":47,"role":43,"phone":48,"phoneExt":24,"email":49},"Musa Zengin, Associate Professor","00905307716235","musazengin@gmail.com",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Atakan Sezgi","Principal Investigator","100626013","flow-controlled-versus-volume-controlled-ventilation-in-bariatric-surgery-100626013",false,"NCT07430111","Flow-Controlled Versus Volume-Controlled Ventilation in Bariatric Surgery","Comparison of Flow-Controlled and Volume-Controlled Ventilation During Bariatric Surgery: A Prospective Randomized Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* ASA physical status II-III\n\nExclusion Criteria:\n\n* ASA physical status I or IV and above\n* Known or previously diagnosed pulmonary disease\n* Patients with severe preoperative pulmonary function impairment (e.g., FEV₁ \\\u003C 50% predicted, severe restrictive or obstructive pathology)\n* Patients with markedly altered lung anatomy or function due to prior major thoracic surgery\n* Patients who were dependent on supplemental oxygen therapy in the preoperative period\n* Refusal to participate in the study or inability to comply with study procedures","ALL","18 Years","65 Years",{"count":65,"type":66},40,"ESTIMATED","INTERVENTIONAL",[69],"NA","This prospective trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in bariatric surgery under general anesthesia. Obesity is associated with altered respiratory mechanics, reduced functional residual capacity, and increased airway pressures, making the selection of an optimal ventilation strategy particularly important in this patient population.\n\nAdult patients aged 18-65 years with a body mass index ≥30 kg\u002Fm² and American Society of Anesthesiologists (ASA) physical status II-III will be allocated to receive either FCV or VCV as part of routine intraoperative mechanical ventilation. Ventilatory parameters, including peak and plateau airway pressures, pulmonary compliance, will be recorded at predefined intraoperative time points.\n\nThe primary endpoint of the study is the PaO₂ value measured at the 20th minute under an FiO₂ of 0.8-1.0.\n\nBy providing comparative data on respiratory mechanics and oxygenation, this study aims to contribute to the identification of lung-protective ventilation strategies and to optimize intraoperative ventilatory management in bariatric surgery.",[72,73,74],"Obesity","Bariatric Surgery","Mechanical Ventilation",[72,76,77],"Flow-Controlled Ventilation","Volume-Controlled Ventilation","2026-02-24",{"date":80,"type":81},"2026-02-25","ACTUAL",{"date":78,"type":81},{"date":84,"type":66},"2027-02-18",{"name":5,"class":6},1]