[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100535429":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":28,"locations":38,"responsibleParty":64,"collaborators":24,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":68,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":24,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":57,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"Hospices Civils de Lyon","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"VeXUS score guided fluid management","EXPERIMENTAL","Fluid management:\n\n* Restrictive intake\n* Diuretic-induced fluid removal aiming for a diuresis of 2-4mL\u002FKg\u002Fh if VeXUS score \\> 1\n* During 24 to 48 hours",[13],"Other: VeXUS score guided fluid management strategy",{"label":15,"type":6,"description":16,"interventionNames":17},"Usual care","Fluid management:\n\n* Usual care\n* at the discretion of the attending physician",[18],"Other: Usual care",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"VeXUS score guided fluid management strategy","During the first 3 postoperative days, the VeXUS score is estimated daily by ultrasound. If VeXUS score \\>1, diuretic-induced fluid removal will be administred (target diuresis: 2-4mL\u002Fkg\u002Fh). The diuretic administration protocol is derived from the CARRESS HF study: bolus followed by a continuous administration of Furosemide with thiazide added based on preoperative diuretic administration status.\n\nTo prevent hypokalaemia and dysnatremia, a protocol for potassium supplementation and intravenous administration of chloride serum or hypotonic perfusion is planned.\n\nFluid removal will be suspended if severe metabolic disturbance (pH\\>7.55 with HCO3-\\>40mmol\u002FL or serum K+ \\\u003C3 mmol\u002FL or serum Na\\>150 mmol\u002FL) or haemodynamic instability (hypoperfusion) with fluid responsiveness occurs. Regardless of the VeXUS score, diuretics will be introduced in case of pulmonary oedema.\n\nHaemodynamic status will be every 12 hours to detect side effects attributable to diuretic-induced fluid removal.",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"Fluid management will be at the discretion of attending physician, who will be blinded to the patient's VeXUS score status.",[15],[29,34],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Jean-Luc Fellahi, MD","CONTACT","+334 72 31 89 44","jean-luc.fellahi@chu-lyon.fr",{"name":35,"role":31,"phone":36,"phoneExt":24,"email":37},"RUSTE Martin, MD","+334 72 11 89 56","martin.ruste@chu-lyon.fr",[39,55],{"facility":40,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Hôpital Louis Pradel, Groupement Hospitalier Est, Hospices Civils de Lyon","NOT_YET_RECRUITING","Bron","69500","France","FR",{"type":47,"coordinates":48},"Point",[49,50],4.91303,45.73865,{"lat":50,"lon":49},[53],{"name":54,"role":31,"phone":32,"phoneExt":24,"email":33},"Fellahi Jean-Luc, MD",{"facility":56,"status":57,"city":42,"state":24,"zip":24,"country":44,"countryCode":45,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Hopital cardiologique Louis Pradel","RECRUITING",{"type":47,"coordinates":59},[49,50],{"lat":50,"lon":49},[62],{"name":63,"role":31,"phone":24,"phoneExt":24,"email":24},"FELLAHI Jean-Luc, MD",{"type":65,"investigatorFullName":24,"investigatorTitle":24,"investigatorAffiliation":24,"oldNameTitle":24,"oldOrganization":24},"SPONSOR","100535429","fluid-removal-guided-by-vexus-score-with-usual-care-in-patients-with-acute-kidney-injury-after-cardiac-surgery-100535429",false,"NCT06251713","Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery","Feasibility of a Randomised Trial Comparing a Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac Surgery: a Pilot Randomised Trial.","VeXUS","Inclusion Criteria:\n\n* Intensive care unit admission within 72 hours of cardiac surgery with extracorporeal circulation\n* Acute kidney injury defined by KDIGO criteria\n* Vasoactive inotropic score \\\u003C45 and capillary refill time \\\u003C3s\n* Informed written consent\n\nExclusion Criteria:\n\n* Hypokalaemia \\\u003C3.5mmol\u002FL\n* Hyponatremia\\\u003C125mmol\u002FL\n* Hypernatremia \\>145mmol\u002FL\n* Metabolic alkalosis with pH \\>7.50\n* Impossibility to measure capillary refill time\n* Chronic liver disease\n* Cirrhosis with portal hypertension\n* Known thrombus of the inferior vena cava\n* Mechanical circulatory assistance (ECMO or mono left ventricular assistance)\n* Severe pre-operative chronic kidney disease (GFR \\\u003C 30mL\u002Fmin\u002F1.73m2)\n* Need for renal replacement therapy anticipated by the attending physician within 24 hours\n* Known hypersensitivity to Furosemide and\u002For hydrochlorothiazide\n* Severe allergy to wheat\n* Patient already included in another interventional study with an exclusion period still in progress\n* Pregnant, breast-feeding or women of childbearing age without suitable contraception\n* Patients under guardianship, curatorship or safeguard of justice\n* Patients under psychiatric care\n* Patients not affiliated to a social security scheme or beneficiaries of a similar scheme","ALL","18 Years","85 Years",{"count":78,"type":79},40,"ESTIMATED","INTERVENTIONAL",[82],"NA","Acute kidney injury affects more than 30% of patients after cardiac surgery, and is associated with an excess in mortality. There is a clinical continuum between acute kidney injury (transient if \\\u003C48h, persistent if \\>48h), the development of acute kidney and chronic renal failure. Each of these entities characterising renal recovery is associated with an increase in long-term morbidity and mortality. Fluid management in patients with acute kidney injury is challenging, as both hypovolaemia and hypervolaemia are detrimental. Venous congestion (reflecting intravascular hypervolaemia), is a well-established haemodynamic factor contributing to acute kidney injury after cardiac surgery. An ultrasound score, based on the venous doppler pattern explored in intra-abdominal organs, has recently been developed and is a better predictor of acute kidney injury than central venous pressure. Whether using the VeXUS score to guide fluid removal in haemodynamically stabilised patients could promote renal recovery after acute kidney injury remains to be investigated.\n\nBefore designing a large randomised trial to test such a strategy, its feasibility in a pilot randomised trial is assessed.",[85,86,87,88],"Acute Kidney Injury","Cardiac Surgery","Venous Congestion","Hemodynamic Stability",[90,91,87,92,93,94],"Acute kidney injury","Cardiac surgery","VeXUS score","diuretic","fluid removal","2025-04-09",{"date":97,"type":98},"2025-04-13","ACTUAL",{"date":100,"type":98},"2024-07-31",{"date":102,"type":79},"2026-07",{"name":5,"class":6},2]