[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100396242":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":44,"collaborators":10,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":10,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":55,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":10,"studyType":61,"phases":10,"briefSummary":62,"conditions":63,"keywords":72,"overallStatus":30,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Boston Children's Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"CXL group",null,"Patients who are about to undergo a corneal cross-linking (CXL) surgery to treat keratoconus.",{"label":13,"type":10,"description":14,"interventionNames":10},"Control group","Healthy volunteers age and sex matched to the CXL group.",[16],{"name":17,"affiliation":5,"role":18},"Eric A Moulton, OD PhD","PRINCIPAL_INVESTIGATOR",[20,24],{"name":17,"role":21,"phone":22,"phoneExt":10,"email":23},"CONTACT","617-919-6827","eric.moulton@childrens.harvard.edu",{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},"Nicholas J Pondelis, BA","617-919-1895","nicholas.pondelis@childrens.harvard.edu",[29],{"facility":5,"status":30,"city":31,"state":32,"zip":33,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Boston","Massachusetts","02115","United States","US",{"type":37,"coordinates":38},"Point",[39,40],-71.05977,42.35843,{"lat":40,"lon":39},[43],{"name":25,"role":21,"phone":26,"phoneExt":10,"email":27},{"type":18,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Eric Moulton","Assistant Professor of Anesthesia","100396242","fmri-and-ivcm-cornea-microscopy-of-cxl-in-keratoconus-100396242",false,"NCT04439552","fMRI and IVCM Cornea Microscopy of CXL in Keratoconus","Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus","Inclusion Criteria:\n\nCXL Group\n\n* Age 8-35 years\n* Clinical diagnosis of keratoconus and seeking CXL treatment\n* English speaking ability sufficient to comprehend consent with parental assistance\n* MRI compatible\n* Ability to lie still for an MRI session (60 minutes)\n\nControl Group\n\n* Age 8-35 years\n* No diagnosis of keratoconus\n* English speaking ability sufficient to comprehend consent with parental assistance\n* MRI compatible\n* Ability to lie still for an MRI session (60 minutes)\n\nExclusion Criteria (Both Groups):\n\n* Claustrophobic\n* Weight \\> 285 lbs (weight limit of the MRI table)\n* Significant medical history, including:\n\nCurrent DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes\n\n* Magnetic implants or metal-containing tattoos on their chest or above\n* Pregnancy\n* History of contact lens wear\n* Any allergic response to a numbing eyedrop in the past",true,"ALL","8 Years","35 Years",{"count":59,"type":60},60,"ESTIMATED","OBSERVATIONAL","Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).",[64,65,66,67,68,69,70,71],"Pain, Postoperative","Pain, Chronic","Pain, Acute","Surgical Injury","Surgical Wound","Cornea Injury","Cornea","Keratoconus",[73,74,75,76],"fMRI","Corneal Microscopy","IVCM","Neuroimaging","2025-12-15",{"date":79,"type":80},"2025-12-19","ACTUAL",{"date":82,"type":80},"2021-10-04",{"date":84,"type":60},"2027-12",{"name":5,"class":6},1]