[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100529790":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":43,"centralContacts":47,"locations":53,"responsibleParty":71,"collaborators":73,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":42,"eligibilityCriteria":83,"healthyVolunteers":79,"sex":84,"minAge":85,"maxAge":42,"enrollmentInfo":86,"targetDuration":42,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":42,"overallStatus":56,"whyStopped":42,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":108},{"fullName":5,"class":6},"University of California, Davis","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Treatment (cryosurgery, high intensity focused ultrasound)","EXPERIMENTAL","Patients undergo focal cryotherapy or high intensity focused ultrasound on study.",[13,14,15],"Procedure: Cryosurgery","Procedure: High-Intensity Focused Ultrasound Ablation","Other: Survey Administration",[17,26,38],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"PROCEDURE","Cryosurgery","Undergo focal cryotherapy ablation",[9],[23,24,25],"Ablation, Cryo","Cryoablation","cryosurgical ablation",{"type":18,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"High-Intensity Focused Ultrasound Ablation","Undergo high intensity frequency ultrasound ablation",[9],[31,32,33,34,35,36,37],"Echopulse","Echotherapy","HIFU","High Intensity Focused Ultrasound","High Intensity Focused Ultrasound Therapy","High-intensity Focused Ultrasound","High-intensity Focused Ultrasound Therapy",{"type":6,"name":39,"description":40,"armGroupLabels":41,"otherNames":42},"Survey Administration","Ancillary studies",[9],null,[44],{"name":45,"affiliation":5,"role":46},"Marc Dall'Era","PRINCIPAL_INVESTIGATOR",[48],{"name":49,"role":50,"phone":51,"phoneExt":42,"email":52},"Office of Clinical Research","CONTACT","916-382-6970","OCRReferral@health.ucdavis.edu",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"University of California Davis Comprehensive Cancer Center","RECRUITING","Sacramento","California","95817","United States","US",{"type":63,"coordinates":64},"Point",[65,66],-121.4944,38.58157,{"lat":66,"lon":65},[69,70],{"name":49,"role":50,"phone":51,"phoneExt":42,"email":52},{"name":45,"role":46,"phone":42,"phoneExt":42,"email":42},{"type":72,"investigatorFullName":42,"investigatorTitle":42,"investigatorAffiliation":42,"oldNameTitle":42,"oldOrganization":42},"SPONSOR",[74],{"name":75,"class":76},"National Cancer Institute (NCI)","NIH","100529790","focal-ablation-with-focal-cryotherapy-or-hifu-for-the-treatment-of-men-with-localized-prostate-cancer-100529790",false,"NCT06178354","Focal Ablation With Focal Cryotherapy or HIFU for the Treatment of Men With Localized Prostate Cancer","A Pragmatic Phase 2 Study of Focal Ablation (Focal Cryotherapy or High Intensity Frequency Ultrasound) in Men With Clinically Localized Prostate Cancer","Inclusion Criteria:\n\n* Ability to understand and willingness to sign an informed consent form\n* Clinically localized grade group 1, 2, or 3 prostate cancer and unilateral magnetic resonance imaging (MRI) visible lesion(s). Up to 3 lesions will be allowed for focal treatment\n* Eastern Cooperative Oncology Group (ECOG) performance status ≤ 1 (Karnofsky ≥ 70%)\n* Patients ≥ 18 years of age at time of consent\n* Life expectancy ≥ 5 years\n* Ability and stated willingness to adhere to the study visit schedule and other protocol procedures\u002Frequirements for the duration of the study\n\nExclusion Criteria:\n\n* Nodal or distant metastases\n* Prior treatment for prostate cancer\n* Anticipated treatment with any cancer intervention, including radiation, hormonal therapy or surgery ≤ 6 months prior to focal therapy in this study\n* Known contraindications to general anesthesia\n* Uncorrectable coagulopathy\n* Significant active cardiac disease within the previous 6 months including: New York Heart Association (NYHA) class 4 congestive heart failure (CHF), unstable angina, or myocardial infarction\n* Any condition that would prohibit the understanding or rendering of informed consent\n* Any condition that in the opinion of the investigator would interfere with the participant's safety or compliance while on trial","MALE","18 Years",{"count":87,"type":88},100,"ESTIMATED","INTERVENTIONAL",[91],"NA","This clinical trial evaluates the effectiveness of focal ablation with either focal cryotherapy or high intensity frequency ultrasound for the treatment of men with localized prostate cancer. Focal cryotherapy kills tumor cells by freezing them. High intensity frequency ultrasound uses highly focused ultrasound waves to produce heat and destroy tumor cells.",[94,95,96,97,98],"Localized Prostate Carcinoma","Stage I Prostate Cancer AJCC v8","Stage II Prostate Cancer AJCC v8","Stage IIIA Prostate Cancer AJCC v8","Stage IIIB Prostate Cancer AJCC v8","2026-06-25",{"date":101,"type":102},"2026-06-30","ACTUAL",{"date":104,"type":102},"2023-11-09",{"date":106,"type":88},"2029-06",{"name":5,"class":6},1]