[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100391890":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":7,"centralContacts":7,"locations":8,"responsibleParty":30,"collaborators":7,"id":34,"slug":35,"hasResults":36,"nctId":37,"briefTitle":38,"officialTitle":39,"acronym":7,"eligibilityCriteria":40,"healthyVolunteers":41,"sex":42,"minAge":43,"maxAge":44,"enrollmentInfo":45,"targetDuration":7,"studyType":48,"phases":7,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":11,"whyStopped":7,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},{"fullName":5,"class":6},"Chinese University of Hong Kong","OTHER",null,[9],{"facility":10,"status":11,"city":12,"state":7,"zip":7,"country":12,"countryCode":13,"cosmosGeoPoint":14,"geoPoint":19,"contacts":20},"The Chinese University of Hong Kong","RECRUITING","Hong Kong","HK",{"type":15,"coordinates":16},"Point",[17,18],114.17469,22.27832,{"lat":18,"lon":17},[21,26],{"name":22,"role":23,"phone":24,"phoneExt":7,"email":25},"Pui Wah Chung","CONTACT","85235051537","jacquelinechung@cuhk.edu.hk",{"name":27,"role":23,"phone":28,"phoneExt":7,"email":29},"Wing Ching Cheung, PhD","85235051764","cosycheung@cuhk.edu.hk",{"type":31,"investigatorFullName":32,"investigatorTitle":33,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"PRINCIPAL_INVESTIGATOR","Chung Pui Wah Jacqueline","Associate Professor","100391890","follicular-fluid-exosome-mirna-during-oocyte-maturation-100391890",false,"NCT04382872","Follicular Fluid Exosome miRNA During Oocyte Maturation","Investigation of Follicular Fluid Exosome miRNA in Young and Aged Women During Oocyte Maturation","Inclusion Criteria:\n\n1. Women aged 20 to 45;\n2. BMI \\> 19 \\& \\\u003C 35;\n3. Women who is planning to perform invitro fertilization (IVF) together with intracytoplasmic sperm injection (ICSI) for their fertility problems\n\nExclusion Criteria:\n\n1. Positive pregnancy test before taking study medications;\n2. Women with BMI\\>35 kg\u002Fm2;\n3. Women with known chromosomal translocation, recurrent abortions or those carrying Fragile X;\n4. Women with endometriosis",true,"FEMALE","20 Years","45 Years",{"count":46,"type":47},60,"ESTIMATED","OBSERVATIONAL","Folliculogenesis involves the recruitment of primordial follicles into a group of growing follicles in which eventually one follicle is selected, matured and ovulated. Complex endocrine and intra-ovarian paracrine interactions occur to create a changing intra-follicular hormonal milieu suitable for oocyte development. However, this oocyte developmental competence and to undergo fertilization and embryogenesis is impaired in aged women. Diminished ovarian function is generally attributed to decreased quantity and quality of oocytes and their surrounding granulosa cells during ovarian aging, although the underlying mechanisms remain unclear.\n\nThe aim of the study is to investigate the miRNA in (follicular fluid) FF exosome in young and aged women and their relationship to egg maturation.",[51],"Oocyte Maturation",[53,54],"oocyte maturation","in vitro maturation","2025-08-12",{"date":57,"type":58},"2025-08-13","ACTUAL",{"date":60,"type":58},"2021-04-30",{"date":62,"type":47},"2026-04-30",{"name":5,"class":6},1]