[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100419557":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":27,"centralContacts":31,"locations":36,"responsibleParty":55,"collaborators":58,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":24,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":39,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Oregon Health and Science University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-Fat Diet","EXPERIMENTAL","50% fat, 35% carbohydrate and 15% protein; 33% of each mono, poly and saturated fat",[13],"Other: High-Fat Diet",{"label":15,"type":16,"description":17,"interventionNames":18},"Low-Fat Diet","ACTIVE_COMPARATOR","30% fat, 55% carbohydrate and 15% protein",[19],"Other: Low-Fat Diet",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"The diet will consist of a breakfast, lunch, dinner, and snack",[9],null,{"type":6,"name":15,"description":22,"armGroupLabels":26,"otherNames":24},[15],[28],{"name":29,"affiliation":5,"role":30},"Andrew McHill, PhD","PRINCIPAL_INVESTIGATOR",[32],{"name":29,"role":33,"phone":34,"phoneExt":24,"email":35},"CONTACT","503-494-2594","mchill@ohsu.edu",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Oregon Health & Science University","RECRUITING","Portland","Oregon","97239","United States","US",{"type":46,"coordinates":47},"Point",[48,49],-122.67621,45.52345,{"lat":49,"lon":48},[52],{"name":53,"role":33,"phone":54,"phoneExt":24,"email":35},"Andrew W McHill, PhD","5034942594",{"type":30,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Andrew McHill","Principal Investigator",[59],{"name":60,"class":61},"National Institutes of Health (NIH)","NIH","100419557","food-and-circadian-timing-100419557",false,"NCT04743271","Food and Circadian Timing","Uncovering the Impact of Diet on the Human Circadian Timing System","FACT","Inclusion Criteria:\n\n* Healthy, lean men and women\n\nExclusion Criteria:\n\n* Major dietary restrictions (such as entirely dairy-free and\u002For meat-free diets)\n* A body mass index (BMI) of 18.5\\\u003C \\[BMI\\] \\\u003C 24.9 kg\u002Fm\\^2 and a waist circumference \\\u003C94\u002F80cm\n* Currently psychiatrically\u002Fpsychologically unsuitable for participation\n* Drug\u002Falcohol use, including smoking\n* Medication\u002Fdrug use, including prescribed and over-the-counter medications\n* History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.\n* Traveled across more than 1 time zone during the 3 months prior to the study\n* Currently consuming a habitual high-fat diet\n* Chronobiologic and sleep disorders\n* Diseases of the Cardiovascular System\n* Metabolic Syndrome; Two or more of these factors will be excluded from the study:\n\n  1. HDL cholesterol of less than 40 mg\u002FdL in men or less than 50 mg\u002FdL in women;\n  2. systolic blood pressure\\>135 mmHg or diastolic blood pressure\\>85 mmHg;\n  3. Fasting blood glucose ≥ 100 mg\u002FdL;\n  4. Triglycerides ≥ 150 mg\u002FdL.\n* Pre-Diabetes\u002FDiabetes\n* Hypertension\n* Disorders of the Respiratory System\n* Disorders of the Kidney and Urinary Tract\n* Infectious Diseases\n* Disorders of the Gastrointestinal System\n* Disorders of the Immune System\n* Disorders of the Hematopoietic System\n* Neoplastic Diseases\n* Endocrine and Metabolic Diseases\n* Neurologic Disorders\n* Subjects must not be currently participating in another research study that would influence their safe participation in our study",true,"ALL","18 Years","40 Years",{"count":75,"type":76},14,"ESTIMATED","INTERVENTIONAL",[79],"NA","The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.",[82,83],"Diet, High-Fat","Circadian Rhythm",[83,85,86],"High Fat","Diet","2025-11-05",{"date":89,"type":90},"2025-11-10","ACTUAL",{"date":92,"type":90},"2022-04-01",{"date":94,"type":76},"2026-03-31",{"name":5,"class":6},1]