[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623151":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":39,"centralContacts":44,"locations":53,"responsibleParty":72,"collaborators":30,"id":74,"slug":75,"hasResults":76,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":30,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":82,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":30,"studyType":88,"phases":89,"briefSummary":91,"conditions":92,"keywords":98,"overallStatus":56,"whyStopped":30,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":115},{"fullName":5,"class":6},"The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Glucose Challenge","EXPERIMENTAL","Participants receive a single 200 kcal liquid meal consisting of 50 g glucose powder dissolved in water to a final volume of 300 mL, administered 6 hours after consuming a standardized pre-load meal.",[13],"Dietary Supplement: Glucose Liquid Meal",{"label":15,"type":10,"description":16,"interventionNames":17},"Fat Challenge","Participants receive a single 200 kcal liquid meal consisting of 100 mL intralipid emulsion diluted with water to a final volume of 300 mL, administered 6 hours after consuming a standardized pre-load meal.",[18],"Dietary Supplement: Fat Liquid Meal",{"label":20,"type":10,"description":21,"interventionNames":22},"Protein Challenge","Participants receive a single 200 kcal liquid meal consisting of 54 g whey protein isolate powder dissolved in water to a final volume of 300 mL, administered 6 hours after consuming a standardized pre-load meal.",[23],"Dietary Supplement: Protein Liquid Meal",[25,31,35],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DIETARY_SUPPLEMENT","Glucose Liquid Meal","A standardized, isocaloric (200 kcal), isovolumetric (300 mL) liquid meal containing 50 g pure glucose. Administered orally 6 hours after a standardized pre-load meal.",[9],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Fat Liquid Meal","A standardized, isocaloric (200 kcal), isovolumetric (300 mL) liquid meal prepared from 100 mL of intralipid emulsion diluted with water. Administered orally 6 hours after a standardized pre-load meal.",[15],{"type":26,"name":36,"description":37,"armGroupLabels":38,"otherNames":30},"Protein Liquid Meal","A standardized, isocaloric (200 kcal), isovolumetric (300 mL) liquid meal containing 54 g whey protein isolate powder. Administered orally 6 hours after a standardized pre-load meal.",[20],[40],{"name":41,"affiliation":42,"role":43},"Yan Bi","Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University","PRINCIPAL_INVESTIGATOR",[45,49],{"name":41,"role":46,"phone":47,"phoneExt":30,"email":48},"CONTACT","6-25-83-105302","biyan@nju.edu.cn",{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},"Zhou Zhang","86-25-83-105302","zhangzhou@smail.nju.edu.cn",[54],{"facility":55,"status":56,"city":57,"state":58,"zip":59,"country":60,"countryCode":61,"cosmosGeoPoint":62,"geoPoint":67,"contacts":68},"Department of Endocrinology, Endocrine and Metabolic Disease Medical Center,Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University","RECRUITING","Nanjing","Jiangsu","China 210008","China","CN",{"type":63,"coordinates":64},"Point",[65,66],118.77778,32.06167,{"lat":66,"lon":65},[69,70,71],{"name":41,"role":46,"phone":47,"phoneExt":30,"email":48},{"name":50,"role":46,"phone":51,"phoneExt":30,"email":52},{"name":41,"role":43,"phone":30,"phoneExt":30,"email":30},{"type":43,"investigatorFullName":41,"investigatorTitle":73,"investigatorAffiliation":5,"oldNameTitle":30,"oldOrganization":30},"Chief Physician","100623151","food-intake-related-brain-and-metabolic-responses-in-obesity-100623151",false,"NCT07392905","Food Intake-Related Brain and Metabolic Responses in Obesity","Association Between Food Intake-Related Brain Functional Patterns and Metabolic Profiles in Patients With Obesity: A Randomized Crossover Trial","Inclusion Criteria:\n\nObese participants:\n\n1. BMI ≥ 28 kg\u002Fm²;\n2. Age 18-40 years;\n3. Any gender;\n4. Right-handed.\n\nHealthy control participants:\n\n1. BMI 18.5-23.9 kg\u002Fm²;\n2. Age 18-40 years;\n3. Any gender;\n4. Right-handed.\n\nExclusion Criteria:\n\n1. Diabetes mellitus;\n2. Contraindications or allergies to any ingredient in the standardized meal or macronutrient challenges used in this study;\n3. Central nervous system disorders (e.g., traumatic brain injury, acute cerebral infarction, epilepsy) or psychiatric disorders (e.g., depression, schizophrenia); use of medications acting on the central nervous system within the past 3 months or long-term use;\n4. Severe impairment of liver, kidney, heart, or gastrointestinal function, including alanine aminotransferase (ALT) and\u002For aspartate aminotransferase (AST) levels \\>2 times the upper limit of normal; estimated glomerular filtration rate (eGFR) \\\u003C45 mL\u002Fmin\u002F1.73 m² calculated by the CKD-EPI equation; history of unstable angina or myocardial infarction within the past 3 months, or heart failure classified as New York Heart Association (NYHA) class II or higher; history of gastrointestinal stoma, bowel resection, intestinal obstruction, or peptic ulcer disease;\n5. Contraindications to MRI, such as implanted metallic devices or claustrophobia;\n6. Pregnancy or lactation;\n7. Participation in another clinical trial currently or within the past 3 months; use of nutritional supplements within the past 3 months or long-term use;\n8. History of prior metabolic\u002Fbariatric surgery;\n9. Use of antibiotics or probiotics within the past 1 month;\n10. Use of medications affecting metabolism or causing weight loss within the past 1 month; body weight fluctuation exceeding 3 kg during the month prior to screening;\n11. Unusual dietary habits; daily alcohol intake \\>40 grams, smoking \\>10 cigarettes per day, or coffee consumption ≥2 cups per day.",true,"ALL","18 Years","40 Years",{"count":86,"type":87},60,"ESTIMATED","INTERVENTIONAL",[90],"NA","This study is a prospective, single-center, randomized, controlled, crossover intervention trial. A total of 60 participants, including 30 patients with obesity and 30 healthy controls, will be enrolled. Each participant will receive an isocaloric liquid meal challenge (glucose, fat, or protein) on three separate experimental days, with a washout period of at least 7 days between visits to eliminate carryover effects from the previous intervention. The primary objective is to investigate the association between brain functional patterns and plasma metabolic profiles following the ingestion of different macronutrients in patients with obesity, aiming to uncover potential neuro-metabolic imbalance features.",[93,94,95,96,97],"Obesity","Brain Function","Metabolomics","Feeding Behavior","Macronutrients",[99,100,101,102,103,104,105],"obesity","macronutrient","fMRI","Cross-over trial","Plasma metabolome","Satiety","Nutrient challenge","2026-01-31",{"date":108,"type":109},"2026-02-06","ACTUAL",{"date":111,"type":109},"2025-12-21",{"date":113,"type":87},"2027-09-01",{"name":5,"class":6},1]